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Francis Lévi, Warwick Medical School, University of Warwick, July 21, 2014:

- Circadian control of xenobiotic carcinogenesis and cancer pharmacology

- Toward Systems Cancer Chronotherapeutics and its integration into home care 

La Société Francophone de Chronobiologie (SFC) organise son 44ème congrès qui se déroulera du 29-31 octobre 2014

Séance de la Société de Biologie " La chronobiologie " aura lieu le 15 octobre 2014 de 15h00 à 18h00 Institut Curie-Pavillon Curie Amphithéâtre Marie Curie 11, rue Pierre et Marie Curie – Paris 5ème

La soutenance de thèse de Melle Véronique ROCHE sera présentée le 21 mai 2014

Reportage BBC, 13 mai 2014  Chronotherapy: The science of timing drugs to our Body

Journal "Le monde" le 30 avril 2014, "Quand l'horloge biologique se détraque"

 

Voir la suite

Contact

UMRS 935

Equipe3 : Chronothérapie des cancers

et optimisation de la fonction hépatique

INSERM et Université Paris Sud

Bât A 3ème étage Campus CNRS
7 rue Guy Môquet
94801 Villejuif Cedex (France)
Tel :  +33 (0) 1 49 58 34 83
Fax : +33 (0) 1 49 58 34 59
Email:gladys.germe@inserm.fr

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Circadian and Cell Cycle Clock systems in Cancer Systems

Mammalian cells are endowed with biological oscillators which time their activities. The circadian clock (circa, about; dies, day) generates a 24-hour rhythm which controls both cellular metabolism and cell division.

The cell division cycle is an oscillator which times DNA synthesis,mitosis, and related apoptosis and DNA repair.

Our understanding of the molecular mechanisms at work in both oscillators has greatly improved. In sharp contrast, little is known about how these two crucial oscillators interact, and how these interactions affect cellular proliferation in normal or cancer cells.

On the one hand, the disruption of circadian clocks impairs cell physiology and quality of life.

On the other hand, disruption of cell cycle, DNA repair or apoptosis impacts on cell and organism survival. Experimental and clinical data show that circadian disruption accelerates malignant proliferation, and that DNA damage can reset the circadian clock.

The central question addressed is how interactions between the circadian clock and cell cycle affect cellular proliferation and genotoxic sensitivity in normal and cancer cells, and how this knowledge translates into new prevention or therapeutic applications.

 

Seven teams in France, Netherlands and United Kingdom integrate experimental, mathematical and bioinformatic approaches, so as to develop novel cell lines, biomarker monitoring methods and mathematical tools. C5Sys triggers innovative chronotherapeutic research for human cancers and advances systems medicine for improving patient care.

Equipes participantes :

Francis Lévi (Coordinateur), RBC, INSERM U776, Villejuif, France

Gijsbertus T.J. van der Horst, Erasmus MC, Rotterdam, Pays-Bas

David Whitmore, UCL, University College London, Londres, Royaume-Uni

Franck Delaunay, IBDC UMR 6543, Nice, France

Ali Mohammad Djafari, L2S SUPELEC, Gif-Sur-Yvette, France

Jean Clairambault et François Fages, INRIA Rocquencourt, Le Chesnay, France

David Rand (co-coordinateur), WSB, University of Warwick, Coventry, Royaume-Uni

Conseiller scientifique :

Albert Goldbeter, Unité de Chronobiologie Théorique, ULB, Bruxelles, Belgique

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Mise à jour le : 22/04/2015

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