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Francis Lévi, Warwick Medical School, University of Warwick, July 21, 2014:

- Circadian control of xenobiotic carcinogenesis and cancer pharmacology

- Toward Systems Cancer Chronotherapeutics and its integration into home care 

La Société Francophone de Chronobiologie (SFC) organise son 44ème congrès qui se déroulera du 29-31 octobre 2014

Séance de la Société de Biologie " La chronobiologie " aura lieu le 15 octobre 2014 de 15h00 à 18h00 Institut Curie-Pavillon Curie Amphithéâtre Marie Curie 11, rue Pierre et Marie Curie – Paris 5ème

La soutenance de thèse de Melle Véronique ROCHE sera présentée le 21 mai 2014

Reportage BBC, 13 mai 2014  Chronotherapy: The science of timing drugs to our Body

Journal "Le monde" le 30 avril 2014, "Quand l'horloge biologique se détraque"

 

Voir la suite

Contact

UMRS 935

Equipe3 : Chronothérapie des cancers

et optimisation de la fonction hépatique

INSERM et Université Paris Sud

Bât A 3ème étage Campus CNRS
7 rue Guy Môquet
94801 Villejuif Cedex (France)
Tel :  +33 (0) 1 49 58 34 83
Fax : +33 (0) 1 49 58 34 59
Email:gladys.germe@inserm.fr

Home Production scientifique Publication

1978

Reinberg A., Lévi F., Guillet P., Burke J., Nicolai A.: Chronopharmacological study of antihistamines in man with special reference to terfenadine. Eur. J. Clin. Pharmacol., 1978,14: 245-252.

 

1980

Halberg F., Nelson W., Lévi F.,Culley D., Bogden A., Taylor J.: Chronotherapy of rat mammary cancer. Int. J. Chronobiology, 1980, 7: 85-90.

Haus E., Halberg F., Sothern R.B., Lakatua D., Scheving L.E., Sanchez S., Sanchez E., Melby J., Wilson I., Brown H., Berg H., Lévi F., Culley D., Halberg F., Hrushesky W., Pauly J.: Time-varying effects in mice and rats of several synthetic ACTH preparations. Chronobiologia, 1980, 7: 221-226.

Lévi F., Halberg F., Haus E., Sanchez S., Sothern R.B., Halberg E., Hrushesky W., Brown H., Scheving L.E., Kennedy B.J.: Synthetic adrenocorticotropin for optimizing murine circadian chronotolerance for adriamycin. Chronobiologia,1980, 7: 227-244.

 

1981

Lévi F., Halberg F.: Circaseptan (about 7-day) bioperiodicity - spontaneous and reactive- and the search for pacemakers.  La Ricerca Clin. Lab., 1981, 12: 323-370.

Reinberg A., Smolensky M., Lévi F.: Clinical chronopharmacology: aims and perspectives. Biomedicine, 1981, 34: 171-178.

 

1982

Lévi F., Hrushesky W., Blomsquit J., Lakatua D., Haus E., Halberg F., Kennedy B.J.: Reduction of cis-diamminedichloroplatinum nephrotoxicity in rats by optimal circadian drug timing.Cancer Res., 1982, 42: 950-955.

Hrushesky W., Lévi F., Halberg F., Kennedy B.J.: Circadian-stage dependence of cis-diamminedichloroplatinum lethal in rats. Cancer Res., 1982, 42:945-949.

Lévi F., Hrushesky W., Haus E., Halberg F., Kennedy B.J.: Circadian rhythm in lethal, renal and hematologic tolerance for cis-diamminedichloroplatinum (II). Eur. J. Cancer Clin. Oncol., 1982, 18: 471-477.

Hrushesky W., Borch R., Lévi F.: Circadian-stage dependent urinary pharmacokinetics of cisplatin in Man. Clin. Pharmacol. Ther., 1982, 32:330-339.

Reinberg A., Touitou Y., Guillemant S., Lévi F., Lagoguey M.: Rythmes circadiens et circannuels des résultats d'épreuves  fonctionnelles en endocrinologie. Ann. Endocrinol., 1982, 43:309-335.

Lévi F., Hrushesky W., Borch R., Lakatua D., Halberg F., Haus E., Kennedy B.J., Halberg F.: Cisplatin urinary pharmacokinetics and nephrotoxicity: a common circadian mechanism. Cancer Treat. Rep., 1982, 66 (11): 1933-1938.

 

1983

Reinberg A., Touitou Y., Lévi F., Nicolai A.: Circadian and seasonal changes of ACTH-induced effects in healthy young men.Eur. J. Clin. Pharmacol., 1983, 25: 657-665.

Lévi F., Canon C., Blum J.P., Reinberg A., Mathé G.: Large-amplitude circadian rhythm in helper:suppressor ratio of human peripheral blood. Lancet, 1983, 8347: 462-463.

 

 

1984

Lévi F., Blum J.P., Lemaigre G., Bourut C., Reinberg A., Mathé G.: A 4-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors: macroscopic and histologic investigation. Cancer Res., 1984, 44: 2660-2667.

Reinberg A., Lévi F., Smolensky M.: Chronopharmacocinétique clinique. J. Pharmacol., 1984, 15 (suppl.1): 95-124.

Reinberg A., Andlauer P., Bourdeleau P. Lévi F., Bicakova-Rocher A.: Rythme circadien de la force musculaire des mains droite et gauche: désynchronisation chez certains travailleurs postés. C. R. Acad. Sci. Paris (III), 1984, 299: 633-636.

Reinberg A., Brossard T. André M.F., Joly D., Malaury J., Lévi F., Nicolai A.: Interindividual differences in a set of biological rhythms documented during the high arctic summer (79 N)in three healthy subjects. Chronobiology Int., 1984, 2: 127-138.

 

1985

Lévi F., Canon C., Blum J.P., Mechkouri M., Reinberg A., Mathé G.: Circadian and/or circahemidian rhythms in nine lymphocyte-related variables from peripheral blood of healthy subjects. J. Immunol., 1985, 134:217-225.

Decousus H., Croze M., Lévi F., Jaubert J., Perpoint P., Reinberg A., Queneau P.: Variation nycthémérale de l'effet anticoagulant de l'héparine administrée à débit constant par voie intraveineuse. C. R. Acad. Sci. Paris (III), 1985, 300:385-388.

Decousus H., Croze M., Lévi F., Jaubert J., Perpoint B., De Bonadona J.F., Reinberg A., Queneau P.: Circadian changes in the anticoagulant effect of heparin infused at a constant rate. Brit. Med. J., 1985, 290:341-344.

Lévi F., Blum J.P., Lemaigre G., Mathé G.: A histologic evaluation of the four day subrenal assay. Acta Chir. Gynaecol., 1985, 74 (suppl.199): 44-50.

Lévi F., Le Louarn C., Reinberg A.: Chronotherapy of osteoarthritis: timing of administration optimizes indomethacin treatment. Clin. Pharm. Ther., 1985, 372: 77-84.

Reinberg A., Touitou Y., Restoin A., Migraine C., Lévi F., Montagnier H.: The genetic background of circadian and ultradian rhythm patterns of 17-hydroxycorticosteroids: a cross-twin study. J. Endocr., 1985, 105: 247-253.

Lévi F., Mechkouri M., Roulon A., Bailleul F., Lemaigre G., Reinberg A., Mathé G.: Circadian rhythm in tolerance of mice for the new anthracycline analog 4'-0-tetrahydropyranyl-adriamycin. Eur. J. Cancer Clin. Oncol., 1985, 21: 1245-1251.

Lévi F., Mechkouri M., Roulon A., Bailleul F., Horvath C., Reinberg A. Mathé G.: Circadian rhythm in tolerance of mice etoposide. Cancer Treat. Rep., 1985, 69: 1443-1445.

Canon C., Lévi F., Reinberg A., Mathé G.: Circulating CALLA positive lymphocytes exhibit a circadian rhythm in Man. Leukemia Res., 1985, 9: 1539-1546.

Lévi F.: Aspects chronopathologiques et chronothérapeutiques des maladies rhumatismales. J. Suisse Pharm., 1985, 123: 1063-1069.

Reinberg A., Smolensky M., Labrecque G., Cambar J., Lévi F.: Biological rhythms and exposure limits for extended work shifts. Ann. Am. Conf. Med. Hyg., 1985, 12: 89-98.

 

1986

Bailleul F, Lévi F., Reinberg A., Mathé G.: Interindividual differences in the circadian hematologic time structure of cancer patients. Chronobiology Intern., 1986, 3: 47-54.

Lévi F., Benavides M., Touitou Y., Quarteronnet D., Canton D., Uzan A., Guérémy C., Le Fur G., Reinberg A.: Circadian rhythm in peripheral type benzodiazepine binding sites in human platelets. Biochem. Pharmacol., 1986, 35:2623-2625.

Pati A., Roulon A., Lemaigre G., Ferment O., Touitou Y., Reinberg A., Mathé G.: Ciclosporine-induced renal damage in mice and circadian rhythm in drug toxicity. Biome, 1986, 1: 27-33.

Canon C., Lévi F., Touitou Y., Sulon J., Demey-Ponsart E., Reinberg A., Mathé G.: Variations circadiennes et saisonnières du rapport inducteur: suppresseur (OKT4+ : OKT8+) dans le sang veineux de l'homme adulte sain. C. R. Acad. Sci. Paris, (Série III), 1986, 302: 519-524.

Lévi F., Bailleul F., Misset J.L., Reinberg A., Mathé G.: Timing of maintenance chemotherapy for childhood acute lymphoblastic leukemia. Lancet, 1986, 8490: 1160-1161.

Bruguerolle B., Reinberg A., Lévi F.: Publicité médicale et chronopharmacologie. Biomed. Pharmacother., 1986, 40: 206-207.

Kolopp M., Bicakova-Rocher A., Reinberg A., Drouin P., Méjean L., Lévi F., Debry G.: Ultradian, circadian, and circannual rhythms of blood glucose and injected insulin documented in six self-controlled adult diabetics. Chronobiol. Intern., 1986, 3: 265-280.

Lévi F.: Premier Colloque de l'Association de Chronobiologie Médicale. Biomed. Pharmacother., 1986, 40:119.

Focan C., Focan-Henrard D., Colette J., Mechkouri M., Lévi F., Hrushesky W., Touitou Y., Franchimont P.: Cancer-associated alteration of circadian rhythms in carcinoembryonic antigen (CEA) and alphafoetoprotein (AFP) in humans. Anticancer Res., 1986, 6: 1137-1140.

Lévi F.: Chronothérapeutique. Biomed. Pharmacother., 1986, 40: 423.

 

1987

Lévi F., Horvath C., Mechkouri M., Roulon A., Bailleul F., Lemaigre G., Reinberg A., Mathé G.: Circadian time dependence of murine tolerance for the alkylating agent peptichemio. Eur. J. Cancer Clin. Oncol., 1987, 23: 487-497.

Lévi F., Benavides M., Touitou Y., Quarteronnet D., Canton T., Uzan A., Auzeby A., Gueremy C., Sulon J., Le Fur G., Reinberg A.: Circadian rhythm in the membrane of circulating human blood cells: microviscosity and number of benzodiazepine binding sites. A search for regulation by plasma ions, nucleotides, proteins or hormones. Chronobiol. Intern., 1987, 4: 235-243.

Ollagnier M., Decousus H., Cherrah Y., Levi F., Queneau P., Reinberg A.: Circadian changes in the pharmacokinetics of ketoprofen in healthy subjects. Clin. Pharmacokinetics, 1987, 12:367-378.

Motohashi Y., Reinberg A., Lévi F., Nouguier J.P., Benoît O., Forêt J., Bourdeleau P.: Axillary temperature: a circadian marker rhythm for shift workers. Ergonomics, 1987, 30 (9): 1235-1247.

Reinberg A., Pauchet F., Ruff F., Gervais A., Smolensky M., Lévi F., Gervais P., Chaouat P., Abella M.L., Zidani R.: Comparison of once-daily evening versus morning sustained-release theophylline dosing for nocturnal asthma. Chronobiol. Intern., 1987, 4(3): 409-419.

Reinberg A., Lévi F.: Clinical chronopharmacology with special reference to NSAID's. Scand. J. Rheumatol., 1987, suppl. 65: 118-122.

Pati A. , Florentin I., Chung V., De Sousa M., Lévi F., Mathé G.: Circadian rhythm in natural activity and mitogen responsiveness of murine splenocytes. Cell Immunol., 1987, 108: 227-234.

Lévi F., Boughattas A., Blazsek I: Comparative murine chronotoxicity of anticancer agents and related mechanisms. Ann. Rev. Chronopharmacol., 1987, 4: 283-331.

 

 

1988

Lévi F., Canon C., Touitou Y., Sulon J., Demey-Ponsart E., Mechkouri M., Mowzowicz I., Touboul J.P., Reinberg A., Mathé G.: Circadian rhythms in circulating T lymphocyte subtypes, plasma total and free cortisol and testosterone in healthy men. Clin. Exp. Immunol., 1988, 71: 329-335.

Reinberg A., Motohashi Y., Bourdeleau P., Andlauer P., Lévi F., Bicakova-Rocher A.: Alteration of period and amplitude of circadian rhythms in shift workers (with special reference to temperature, right and left hand grifp strength). Eur. J. Appl. Physiol., 1988, 57: 15-25.

Lévi F., Canon C., Touboul J.P., Vannetzel J.M., Reinberg A. Mathé G.: Seasonal modulation of the circadian time structure of circulating T lymphocyte subsets from healthy subjects. J. Clin. Invest., 1988, 81: 407-413.

Petit E., Milano G., Lévi F., Thyss A., Bailleul F., Schneider M.: Circadian varying plasma concentration of 5-fluorouracil during 5-day continuous venous infusion at constant rate in cancer patients. Cancer Res., 1988, 48: 1676-1679.

Jonkman J., Reinberg A., Oosterhuis B., De Noord O.E., Kerkhof F., Motohashi Y., Lévi F., Dammaco F., Carandente F.: Dosing-time and sex-related differences in the pharmacokinetics of cefodizime and in the circadian cortisol rhythm. Chronobiologia, 1988, 15: 89-102.

Reinberg A., Gervais P., Lévi F., Smolensky M., Del Cerro L., Ugolini C.: Circadian and circannual rhythms in allergic rhinitis: an epidemiologic study involving chronobiologic methods. J. Allergy Clin. Immunol., 1988, 81(1): 51-62.

Lévi F., Blazsek I., Ferlé-Vidovic A.: Circadian and seasonal rhythms in murine bone marrow colony forming cells affect tolerance for the anticancer agent 4'-0-tetrahydropyranyladriamycin (THP). Exp. Hematol., 1988, 16:696-701.

Méjean L., Bicakova-Rocher A.,Kolopp M., Villaule C., Lévi F., Debry G., Reinberg A., Drouin P.: Circadian and ultradian rhythms in blood glucose and plasma insulin of healthy adults. Chronobiol. Intern., 1988, 5: 227-236.

Kolopp M., Bicakova-Rocher A., Reinberg A., Drouin P., Méjean L., Lévi F., Debry G.: Ultradian, circadian and circannual rhythms of blood glucose and injected insulin documented in six self-controlled diabetics. Chronobiol. Intern., 1988, 3:265-280.

Boughattas N.A., Lévi F., Hecquet B., Lemaigre G., Roulon A., Fournier A., Reinberg A.: Circadian time dependence of murine tolerance for carboplatin. Toxicol. Appl. Pharmacol., 1988, 96: 233-247.

Touitou Y.,Sothern R., Lévi F., Focan C., Bogdan A., Auzeby A., Franchimont P., Roemeling R.W., Hrushesky W.J.M.: Circadian and circannual aspects of plasma carcinoembryonic antigen (CEA) rhythmicity in health and cancer: effects of chemotherapy. J. Tumor Markers, 1988, 3(4): 351-359.

 

1989

Kottler M.L., Coussieu C.,Valensi P., Lévi F., Degrelle H.: Circadian and seasonal variations of plasma profesterone and LH concentration during the mid-luteal phase in normal women. Chronobiol.Intern.,1989, 6(3): 267-277.

Boughattas N., Lévi F., Fournier C., Lemaigre G., Roulon A., Hecquet B., Mathé G., Reinberg A.: Circadian rhythms in toxicities and tissues uptake of oxaliplatin in mice. Cancer Res., 1989, 49: 3362-3368.

Sothern R.B., Lévi F., Haus E., Halberg F., Hrushesky W.: Control of a murine plasmacytoma with doxorubicin-cisplatin: dependence on circadian stage of treatment. J.Natl.Cancer.Inst., 1989, 81(2): 135-145.

Reinberg A., Lévi F.: Dose-response relationships in chronopharmacology. Ann. Rev. Chronopharmacol., 1989, 6: 25-46.

 

1990

Lévi F., Benavides M., Chevelle C., Le Saulnier F., Bailleul F., Misset J.L., Regensberg C., Vannetzel J.M., Reinberg A., Mathé G.: Chemotherapy of advanced ovarian cancer with 4'-0-tetrahydropyranyl doxorubicin (THP) and cisplatin: a phase II trial with an evaluation of circadian timing and dose intensity. J. Clin. Oncol., 1990, 8(4): 705-714.

Bommelaer-Bayet M.E., Wisner A., Renard C.A., Lévi F., Dray F.: Circadian and estral changes in the hypothalamic PGE2 content and [3H]PGE2 binding in female rats. J. Neuroendocrinol., 1990, 2(2): 193-199.

Villette J.M., Bourin P., Doinel C., Mansour I., Fiet J., Boudou P., Dreux C., Roue R.,Debord M., Lévi F.: Circadian variations in plasma levels of hypophyseal, adrenocortical and testicular hormones in men infected with human immunodeficiency virus. J. Clin. Endocrinol. Metab., 1990, 70(3): 572-577.

Mazy V., Focan C., Dallemagne B., Focan-Henrard D., Longrée L., Markiewicz S., Weerts J., Jehaes C., Jacquet N., Demoulin J.C., Drèze Ch., Fontaine F., Gillard V., Peray P., Delforge M., Lévi F., Lombard R.: Chimiothérapie intraartérielle et intraveineuse dans le traitement des métastases hépatiques à point de départ colorectal: revue de la littérature et résultats préliminaires. Revue Médicale de Liège, 1990, XLV (3):105-116.

Caussanel J.P., Lévi F., Brienza S., Misset J.L., Itzhaki M., Adam R., Milano G., Hecquet B., Mathé G.: Phase I trial of 5-day continuous infusion of oxaliplatin at circadian rhythm modulated rate compared with constant rate. J. Natl. Cancer Inst., 1990, 82: 1046-1050.

Lévi F.: "Chronotherapy of cancers: a new strategy in clinical oncology". Meeting report. Chronobiology Intern., 1990, 7(1): 81-84.

Boughattas N., Lévi F., Fournier C., Hecquet B., Lemaigre G., Roulon A., Mathé G., Reinberg A.: Stable circadian mechanisms of toxicity of two platinum analogs (cisplatin and carboplatin) despite repeated dosages in mice. J. Pharmacol. Exp. Ther., 1990, 255(2):672-679.

Reinberg A., Lévi F.: Dose-response relationships in chronopharmacology. Ann. Rev. Chronopharmacol., 1990, 6: 25-46.

Beau J., Lévi F., Motta R.: The influence of the athymic mutation nude on the components of the circadian rhythm of activity in mice. Chronobiol. Intern., 1990, 5/6: 371-376.

 

1991

Lévi F., Canon C., Di Palma M., Florentin I., Misset J.L.: When should the immune clock be reset? From circadian pharmacodynamics to temporally optimized drug delivery. Ann. N.Y. Acad. Sci., 1991, 618 (Temporal control of drug delivery): 312-329.

Lévi F., Canon C., Deprés-Brummer P., Adam R., Bourin P., Pati A., Florentin I., Misset J.L., Bismuth H.: The rhythmic organization of the immune network : implications for the chronopharmacologic delivery of interferons, interleukins and cyclosporin. Adv. Drug Delivery Rev., 1991, 9: 311-339.

Deprés-Brummer P., Lévi F., Di Palma M., Beliard A., Lebon P., Marion S., Jasmin C., Misset J.L. : A phase I trial of 21-day continuous venous infusion of alpha-Interferon at circadian rhythm modulated rate in cancer patients. J. Immunother., 1991, 10 : 440-447.

 

1992

Lévi F., Misset J.L., Brienza S., Adam R., Metzger G., Itzakhi M., Caussanel J.P., Kunstlinger F., Lecouturier S., Descorps-Declère A., C. Jasmin, Bismuth H., Reinberg A.: A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid and oxaliplatinum using an ambulatory multichannel programmable pump : high antitumor effectiveness against metastatic colorectal cancer. Cancer, 1992, 69 (4) : 893-900.

Lévi F., Canon C., Deprés-Brummer P., Adam R., Bourin P., Pati A., Florentin I., Misset J.L., Bismuth H. : The rhythmic organization of the immune network : implications for the chronopharmacologic delivery of interferons, interleukins and cyclosporin. Advanced Drug Deliv. Rev., 1992, 9 : 85-112.

Touitou Y., Bogdan A., Auzéby A., Lévi F. : The in vitro effect of metyrapone on steroid synthesis in mice adrenals at different circadian stages. Chronobiol. Int., 1992, 9 : 350-355.

 

1993

Lévi F., Perpoint B., Garufi C., Focan C., Chollet P., Deprés-Brummer P., Zidani R., Brienza S., Itzhaki M., Iacobelli S., Kunstlinger F., Gastiaburu J., Misset J.L. Oxaliplatin activity against metastatic colorectal cancer. A phase II study of 5-day continuous venous infusion at circadian-rhythm modulated rate. Eur. J. Cancer, 1993, 29A (9) : 1280-1284.

Vassal G., Challine D., Koscielny S., Hartmann O., Deroussent A., Boland I., Valteau-Couanet D., Lemerle J., Lévi F., Gouyette A. : Chronopharmacology of high-dose busulfan in children and its relationship with liver toxicity. Cancer Res., 1993, 53 : 1534-1537.

Bourin P., Mansour I., Lévi F., Roué R., Rouger P., Doinel C. : Circadian rhythms of circulating NK cells in healthy and human immunodefficiency virus (HIV) infected men. Chronobiol. Intern., 1993, 10 (4) : 298-305.

Bertheault-Cvitkovic F., Soussan S., Brienza S., Adam R., Itzhaki M., Misset J.L., Bismuth H., Lévi F. : Circadian-rhythm modulated chemotherapy with high-dose 5-fluorouracil : a pilot study in patients with pancreatic adenocarcinoma. Eur. J. Cancer, 1993, 29A (13) : 1851-1854.

Focan C., Kreutz F., Lévi F. : Ambulatory treatment with 5-days continuous venous infusion of ifosfamide for advanced colorectal cancer. A Phase II feasibility study. Anti-cancer drugs, 1993, 4 : 459-62.

 

1994

Lévi F., Metzger G., Deprés-Brummer P. : Implications of biological rhythms for toxicology. Drug Inf. Journal, 1994, 28 : 195-202.

Lévi F., Bourin P., Deprés-Brummer P., Adam R. : Chronobiology of the immune system : implication for the delivery therapeutic agents. Clin. Immunother., 1994, 2 (1) : 53-64.

Lévi F. : Chronotherapy of cancer : biological basis and clinical application. Path. Biol., 1994, 42 (4) : 338-341.

Deprés-Brummer P., Metzger G., Larue-Achagiotis C., Touitou Y., Lévi F. : Prolonged exposure of rats to constant light : an animal model of environmentally induced functional suppression of the circadian system. Biol. Rhythm Res., 1994, 25 (2) : 213-215.

Metzger G., Massari C., Etienne M.C., Commisso M., Brienza S., Touitou Y., Milano G., Bastian G., Misset J.L., Lévi F. : Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin : relationship with mucosal toxicity in cancer patients. Clin. Pharm. Ther., 1994, 56 : 190-201.

Lévi F., Zidani R., Vannetzel J.M., Perpoint B., Focan C., Faggiuolo R., Chollet P., Garufi C., Itzhaki M., Dogliotti L., Iacobelli S., Adam R., Kunstlinger F., Gastiaburu J., Bismuth H., Jasmin C., Misset J.L. : Chronomodulated versus fixed infusion rate delivery of ambulatory chemotherapy with oxaliplatin, 5-fluorouracil and folinic acid in patients with colorectal cancer metastases. A randomized multiinstitutional trial. J. Natl. Cancer Inst., 1994, 86 : 1608-1617.

Lévi F., Tampellini M., Metzger G., Bizi E., Lemaigre G., Hallek M. : Circadian changes in mitoxantrone toxicity in mice : relationship with plasma pharmacokinetics. Int. J. Cancer, 1994, 59 : 543-547.

Boughattas N.A., Hecquet B., Fournier C., Bruguerolle B., Trabelski H., Bouzouita K., Omrane B., Lévi F.: Comparative pharmacokinetics of oxaliplatin (L-OHP) and carboplatin (CBDCA) in mice with reference to circadian dosing time. Biopharm. Drug Disp., 1994, 15 (9) : 761-73.

Wolfrom, Raynaud N., Maigne J., Papathanassiou S., Conti M., Kadhom N., Hecquet B., Lévi F., Gautier M., Deschatrette J. : Periodic fluctuations in proliferation of SV-40 transformed human skin fibroblast lines with prolonges lifespan. Cell Biol. Toxicol., 1994, 10 : 247-254.

 

1995

Perpoint B., Le Bousse-Kerdiles C., Clay D., Smadja-Joffe F., Deprés-Brummer P., Laporte-Simitsidis S., Jasmin C., Lévi F. : In vitro chronopharmacology of recombinant mouse IL-3, mouse GM-CSF and human G-CSF on murine myeloid progenitor cells. Exp. Hematol., 1995, 23 : 362-368.

Touitou Y., Lévi F., Bogdan A., Benavides M., Bailleul F., Misset J.L. : Rhythm alteration in patients with metastatic breast cancer and poor prognostic factors. J. Cancer Res. Clin. Oncol., 1995, 121 : 181-188.

Deprés-Brummer P., Lévi F., Metzger G., Touitou Y. : Light-induced suppression of the rat circadian system. Am. J. Phys., 1995, 268 : R1111-R1116.

Lévi F., Giacchetti S., Adam R., Zidani R., Metzger G., Misset J.L. : Chronomodulation of chemotherapy against metastatic colorectal cancer. Eur. J. Cancer, 1995, 31A : 1264-1271.

Levi F. : Chronochimiothérapie et intensité de dose. Bull. Cancer, 1995, 82 : suppl. 1, 29s-35s.

Tampellini M., Filipski E., Lévi F. Circadian variation of vinorelbine toxicity in mice. Chronobiol. Intern., 1995, 12 (3) : 195-198.

Garufi C., Lévi F., Giunta S., Aschelter A., Pace R., Nistico C., Terzoli E. : Chronomodulated 5-day infusion of floxuridine and L-folinic acid in patients with advanced malignancies : a feasibility and tolerability study. J. Infus. Chemother., 1995, 5 (3) : 134-137

Deprés-Brummer P., Bertheault-Cvitkovic F., Lévi F., Brienza S., Vannetzel J.M., Jasmin C., Misset J.L. : Circadian rhythm modulated (CRM) chemotherapy of metastatic breast cancer with mitoxantrone, 5-fluorouracil and folinic acid : preliminary results of a Phase I trial. J. Infus. Chemother., 1995, 5 (3) : 144-147.

Focan C., Denis B., Kreutz F., Focan-Henrard D., Lévi F. : Ambulatory chronotherapy with 5-fluorouracil, folinic acid and carboplatin for advanced non small cell lung cancer. A Phase II feasibility trial. J. Infus. Chemother., 1995, 5 (3) : 148-152.

Lévi F., Soussan A., Adam R., Caussanel J.P., Metzger G., Jasmin C., Bismuth H., Smolensky M., Misset J.L. : A Phase I-II trial of five-day continuous intravenous infusion of 5-fluorouracil delivered at circadian rhythm modulated rate in patients with metastatic colorectal cancer. J. Infus. Chemother., 1995, 5 (3) : 153-158.

 

1996

Lévi F. : Chronotherapy for gastrointestinal cancers. Curr. Opin. Oncol., 1996, 8 : 334-341.

Boughattas N., Li X.M., Filipski J., Lemaigre G., Filipski E., Bouzouita K., Belhadj O., Lévi F. : Modulation of cisplatin chronotoxicology related to reduced glutathione in mice. Hum. Exp. Toxicol., 1996, 15 : 563-572.

Martineau-Pivoteau N., Cussac-Buchdahi C., Chollet P., Rolhion C., Debiton E., Rapp M., Kwiatkowski F., Madelmont J.C., Lévi F. : Circadian variation in O6-methylguanine-DNA methyltransferase activity in mouse liver. Anticancer Drugs, 1996, 7 : 1-7.

Minors D., Akerstedt T., Atkinson G., Dahlitz M., Folkard S., Lévi F., Mormont M.C., Parkes D., Waterhouse J.: The difference between activity when in bed and out of bed. I. Healthy subject and selected patients. Chronobiol. Intern., 1996, 13 : 27-34.

Bismuth H., Adam R., Lévi F., Farabos C., Waechter F., Castaing D., Majno P., Engerran L. : Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann. Surg., 1996, 224 (4) : 509-522.

Bertheault-Cvitkovic F., Jami A., Ithzaki M., Deprés-Brummer P., Brienza S., Adam R., Bismuth H., Misset J.L., Lévi F. : Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil and folinic acid in patients with metastatic colorectal cancer. J. Clin. Oncol., 1996, 14 (11) : 2950-2958.

Touitou Y., Bogdan A., Lévi F., Benavides M., Auzéby A. : Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients. Relationships with tumor marker antigens. Brit. J. Cancer, 1996, 74 : 1248-1252.

Deprés-Brummer P., Metzger G., Morin D., Urien S., Touitou Y., Tillement J.P., Claustrat B., Lévi F. : Pharmacokinetically guided melatonin scheduling in rats with circadian system suppression, Eur. J. Pharmacol., 1996, 312 : 171-178.

Martineau-Pivoteau N., Lévi F., Rolhion C., Kwiatkowski F., G. Lemaigre, Filipski E., Madelmont J.C., Chollet P. : Circadian rhythms in toxic effects of cystemustine in mice : relevance for chronomodulated delivery. Int. J. Cancer, 1996, 68 : 669-674.

 

1997

Lévi F., Zidani R., Misset J.L. for the International Organization for Cancer Chronotherapy : Randomized multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. Lancet, 1997, 350 : 681-686.

Lévi F., Metzger G., Zidani R., Misset J.L. for the International Organization for Cancer Chronotherapy : Chronotherapy with 5-fluorouracil, oxaliplatin, and folinic acid in colorectal cancer. Reply. Lancet, 1997, 350 : 1325-1326.

Mormont M.C., Lévi F. : Circadian system alterations during cancer processes : a review. Int. J. Cancer, 1997, 70 : 241-247.

Deprés-Brummer P., Bourin P., Pages N., Metzger G., Lévi F. : Persistent T lymphocytes rhythms despite suppressed circadian clock outputs in rats. Am. J. Physiol. , 1997, 273 : R1891-R1899.

Li X.M., Metzger G., Filipski E., Boughattas N., Lemaigre G., Hecquet B., Filipski J., Lévi F. : Pharmacologic modulation of reduced glutathione (GSH) circadian rhythms by buthionine sulfoximine (BSO) : relationship with cisplatin (CDDP) toxicity in mice. Toxicol. Appl. Pharmacol., 1997, 143 : 281-290.

Lévi F. : EORTC Chronotherapy Study Group. Eur. J. Cancer, 1997 , 33 (8) : 1162-1163.

Garufi C., Lévi F., Aschelter A.M., Giunta S., Pace R., Nistico C., Tropea F., Cardamone I., Silecchia G.F., Terzoli E. : A Phase I trial of five day chronomodulated infusion of 5-fluorouracil and l-folinic acid in patients with metastatic colorectal cancer. Eur. J. Cancer, 1997, 33 (10) : 1566-1571.

Morin D., Simon N., Deprés-Brummer P., Lévi F., Tillement J.P., Urien S. : Melatonin high affinity binding to alpha1-acid glycoprotein in human serum. Pharmacology, 1997, 54 : 271-275.

Gupta S., Pati A.K., Lévi F. : Pattern of shift rota modulates oral temperature circadian rhythm and sleep-wakefulness profiles in shift workers. J. Biosci., 1997, 22 (4) 477-488.

Hallek M., Touitou Y., Lévi F., Mechkouri M., Bogdan A., Bailleul F., Senekowitsch R., Emmerich B. : Serum thymidine kinase levels are elevated and exhibit diurnal vairations in patients with advanced ovarian cancer. Clinica Chimica Acta, 1997, 267 : 155-166.

 

1998

Tampellini M., Filipski E., Liu X-H, Lemaigre G., Li X-M, Vrignaud P., François E, Bissery M.C., Lévi F : Docetaxel chronopharmacology in mice. Cancer Res., 1998, 58 : 3896-3904.

Deprés-Brummer P., Metzger G., Lévi F. : Pharmacologic restoration of suppressed temperature rhythms in rats with melatonin, melatonin receptor agonist S20242 or 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur. J. Pharmacol., 1998, 347 (1) : 57-66.

Li X.M., Soulard C., Filipski E., Deschamps de Paillette E., Lévi F. : Circadian-based effects of AcSDKP, with or without rhG-CSF on hematologic toxicity of chemotherapy in mice. Eur. J. Haematol., 1998, 60 : 181-188.

Li X.M., Filipski E., Lévi F. : Pharmacological modulation of cisplatin toxicity rhythms with buthionine sulfoximine in mice bearing pancreatic adenocarcinoma (P03). Chronobiol. Intern., 1998, 15 (5) : 323-335.

Li X.M., Metzger G., Filipski E., Lemaigre G., Lévi F. : Modulation of nonprotein sulfhydryl compounds rhythm with buthionine sulfoximine : relationship with oxaliplatin toxicity in mice. Arch. Toxicol., 1998, 72 : 574-579.

Mormont M.C., Hecquet B., Bogdan A., Benavides M., Touitou Y., Lévi F. : Non-invasive estimation of the circadian rhythm in serum cortisol in patients with ovarian or colorectal cancer. Int. J. Cancer, 1998, 78 : 421-424.

 

1999

Li X. M., Ezan E., Bindoula G., Soulard C., Liu X.H., Deschamps de Paillette E., Lévi F. : Chronopharmacologic aspects of continuous AcSDKP infusion in mice. Exp. Hematol., 1999, 27 : 19-27.

Van den Heiligenberg S., Deprés-Brummer P., Barbason H., Claustrat B., Reynes M., Lévi F. : Promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats. Life Sciences, 1999, 64 (26) : 2523-2534.

Lévi F., Zidani R., Brienza S., Dogliotti L., Perpoint B., Rotarski M., Letourneau Y, Llory J F., Chollet P., Le Rol A., Focan C. International Organization for Cancer Chronotherapy : A multicenter evaluation of intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil and leucovorin as initial treatment of patients with metastatic colorectal cancer. Cancer, 1999, 85 (12) : 2532-2540.

Filipski E., Amat S., Lemaigre G., Vincenti M., Breillout F., Lévi F. : Relationship between circadian rhythm of vinorelbine toxicity and efficacy in P388-bearing mice. J. Pharm. Exp. Ther., 1999, 289 : 231-235.

Giacchetti S., Itzhaki M., Gruia G., Adam R., Zidani R., Deprés-Brummer P., Bleuzen P., Bertheault-Cvitkovic F., Kunstlinger F., Brienza S., Jasmin C., Alafaci E., Reynes M., Bismuth H., Misset J.L., Lévi F. : Long term survival of patients with unresectable colorectal liver metastases following infusional chemotherapy with 5-fluorouracil, folinic acid, oxaliplatin and surgery. Ann. Oncol., 1999, 10(6):663-669.

Focan C., Lévi F., Kreutz F., Focan-Henrard D., Lobelle J.P., Adam R., Dallemagne B., Jehaes C., Markiewicz S., Weerts J., Bismuth H., Jasmin C., Misset J.L. : Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodesoxyuridine for hepatic metastases from colorectal cancer : feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. Anti-Cancer Drugs, 1999, 10 : 385-392.

Garufi C., Dogliotti L., Terzoli E., Focan C., Smaaland R., Chollet P., Perpoint B., Lévi F. for the Chronotherapy Study Group of the European Organization for Research and Treatment of Cancer : Letter to the Editor. Tumori, 1999, 85 : 149-150.

Van Cutsem E., Cunningham D., Ten Bokkel Huinink W.W., Punt C.J., Alexopoulos C.G., Dirix L., Symann M., Blijham G.H., Chollet P., Fillet G., Van Groeningen C., Vannetzel J.M., Lévi F., Panagos G., Unger C., Wils J., Cote C., Blanc C., Herait P., Bleiberg H. : Clinical activity and benefit of irinotecan (CPT-11) in patients with colorectal cancer truly resistant to 5-fluorouracil (5-FU). Eur. J. Cancer, 1999, 35 (1) : 54-59.

Li X.M., Lévi F. : Chronopharmacologic effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on hematopoiesis in mice. Biological Rhythm Res., 1999, 30 (3) : 339-345.

Lévi F. : Cancer chronotherapy. J. Pharmacy Pharmacol., 1999, 51 : 891-898.

 

2000

Giacchetti S., Perpoint B., Zidani R., Le Bail N., Faggiuolo R., Focan C., Chollet P., Llory J.F., Letourneau Y., Coudert B., Bertheault-Cvitkovic F., Larregain-Fournier D., Le Rol A., Walter S., Adam R., Misset J.L., Lévi F. for the International Organization of Cancer : Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil – leucovorin as first line treatment of metastatic colorectal cancer. J. Clin. Oncol., 2000, 18 (1) : 136-147.

Lévi F., Metzger G., Massari C., Milano G. : Oxaliplatin. Pharmacokinetics and chronopharmacological aspects. Clinical Pharmacokinetics, 2000, 36 (1) : 1-21.

Giacchetti S., Lévi F. : A new strategy in unresectable metastatic colorectal cancer. (Letter). Ann. Oncol., 2000, 11 (2) : 243-244.

Li X.M., Liu X.H., Filipski E., Metzger G., Delagrange P., Jeanniot J.P., Lévi F. : Relationship of atypical melatonin rhythm with two circadian clock outputs in B6D2F1 mice. Am. J. Physiol. – Regul. Integ. Comp. Physiol., 2000, 278 : R924-R930.

C. Garufi, S. Brienza, P. Pugliese, A.M. Aschelter, M.A. Bensmaine, F. Bertheault-Cvitkovic, C. Nistico, S. Giunta, M. Caterino, D. Giannarelli, M. Cosimelli, F. Lévi, E. Terzoli : Overcoming resistance to chronomodulated 5-fluorouracil and folinic acid by the addition of chronomodulated oxaliplatin in advanced colorectal cancer patients. Anti-Cancer Drugs, 2000, 11 : 495-501.

Mormont M.C., Waterhouse J, Bleuzen P., Giacchetti S., Jami A., Bogdan A., Lellouch J., Misset J.L., Touitou Y., Lévi F. : Marked 24-h rest-activity rhythms are associated with better quality of life, better response and longer survival in patients with metastatic colorectal cancer and good performance status. Clin. Cancer Res., 2000, 6 : 3038-3045.

Misset J.L., Lévi F. : Chronotherapy with 5-fluorouracil and other drugs in gastrointestinal malignancies. Sem. Oncol., 2000, 27 (5, Suppl. 10) : 78-82.

Bensmaine M.A., De Gramont A., Marty M., Lévi F., Ducreux M., François E., Gamelin E., Bleiberg H., Bleuzen P., Simon J., Cvitkovic E. : Factors predicting for efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) ± folinic acid (FA) in a compassionate-use cohort of 370 5-FU-resistant advanced colorectal cancer (CRC) patients. Eur. J. Cancer, 2000, 36 : 2335-2343.

Curé H., Chevalier V., Adenis A., Tubiana-Mathieu N., Niezgodzki G., Kwiatowski F., Pezet D., Perpoint B., Coudert B., Focan C., Lévi F., Chipponi J., Chollet P. : Phase II trial of chronomodulated infusion of high-dose 5-fluorouracil and l-folinic acid in previously untreated patients with metastatic colorectal cancer. Anticancer Res., 2000, 20 : 4649-4654.

Gornet J.M., Azoulay D., Lévi F., Misset J.L., Goldwasser F. : Dramatic tumor response of bulky liver metastases following chemotherapy with CPT11 and chronomodulated infusion of 5-FU, folinic acid and oxaliplatin every 2 weeks in a colorectal cancer patient. Anticancer Drugs, 2000, 11 : 263-268.

 

2001

Marchenay C., Cellarier E., Lévi F., Rolhion C., Kwiatkowski F., Dubray C., Claustrat B., Madelmont J.C., Chollet P. : Circadian variation in O6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects. Int. J. Cancer, 2001, 91 : 60-66.

Lévi F., Giacchetti S., Zidani R., Brézault-Bonnet C., Tigaud J.M., Goldwasser F., Misset J.L. : Chronotherapy of colorectal cancer metastases. Hepato-Gastroenterol. , 2001, 48 : 320-322.

Lévi F. : Circadian chronotherapy for human cancers. Lancet Oncology, 2001, 2 : 307-315.

Adam R., Avisar E., Ariche A., Giacchetti S., Azoulay D., Castaing D., Kunstlinger F., Lévi F. , Bismuth H. : Five years survival after neoadjuvant therapy for non resectable colorectal liver metastases. Ann. Surg. Oncol., 2001, 8 : 347-353.

Granda T.G., Filipski E., D’Attino R.M., Vrignaud P., Anjo A., Bissery M.C., Lévi F. : Experimental chronotherapy of mouse mammary adenocarcinoma MA13/C with docetaxel and doxorubicin as single agents and in combination. Cancer Res., 2001, 61 : 1996-2001.

Mormont M.C., Lévi F. : Chronomodulation of cancer chemotherapy : achivements and perspectives. Drug Delivery Systems & Sciences, 2001, 1 : 48-51. (Invité)

Sun J., Xian L.J., Cao Q.Y., Ye Y.L., Liu X.H., Li X.M., Lévi F. : Circadian rhythms of DNA synthesis in human nasopharyngeal carcinoma cells transplanted in nude mice. Chinese J. Cancer, 2001, 20 (2) : 128-130

Bensmaïne M.A., Marty M., De Gramont A., Brienza S., Lévi F., Ducreux M., François E., Gamelin E., Bleiberg H., Cvitkovic E. : Factors predicting efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) ± folinic acid (FA) in a compassionate-use cohort of 481 5-FU-resistant advanced colorectal cancer (CRC) patients. Brit. J. Cancer, 2001, 85 (4) : 509-17.

2002

B. Coudert, C. Focan, E Donato di Paola, F Lévi for the EORTC Chronotherapy Group (CTG) : It’s time for chronotherapy ! Eur J Cancer, 2002, 38 (Suppl 4) : 50-53.

Curé H., Chevalier V., Adenis A., Tubiana-Mathieu N., Niezgodzki G., Kwiatkowski F., Pezet D., Perpoint B., Coudert B., Focan C., Lévi F., Chipponi J., Chollet P. : Phase II trial of chronomodulated infusion of high-dose 5-fluorouracil and l-folinic acid in previously untreated patients with metastatic colorectal cancer. J. Clin. Oncol., 2002, 20 (5) : 1175-1181.

Giacchetti S., Perpoint B., Zidani R., Le Bail N., Faggiuolo R., Focan C., Chollet P., Llory J.F., Letourneau Y., Coudert B., Bertheault-Cvitkovic F., Larregain-Fournier D., Le Rol A., Walter S., Adam R., Misset J.L., Lévi F. for the International Organization of Cancer : Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil – leucovorin as first line treatment of metastatic colorectal cancer. Update. J. Clin. Oncol., Classic Papers and Current Comments, Highlights of Gastrointestinal Cancer Research, 2002, 6 (4) : 885-897. "A best of the JCO"

Lévi F. : From circadian rhythms to cancer chronotherapeutics. Chronobiol. Int., 2002, 19 (1) : 1-19.

Granda T.G., Lévi F. : Tumor-based rhythms of anticancer efficacy in experimental models. Chronobiol. Int., 2002, 19 (1) : 21-41.

Li X.M, Vincenti M., Lévi F. : Pharmacological effects of vinorelbine on body temperature and locomotor activity circadian rhythms in B6D2F1 mice. Chronobiol. Int., 2002, 19 (1) : 43-55.

Bourin P., Ledain A., Beau J., Mille D., Lévi F.: In vitro circadian rhythm of murine bone marrow progenitors production. Chronobiol. Int., 2002, 19 (1) : 57-67.

Xian L.J., Sun J., Cao Q.Y., Ye Y.L., Liu X.H., Li X.M., Lévi F. : Circadian rhythms of DNA synthesis in nasopharyngeal carcinoma cells. Chronobiol. Int., 2002, 19 (1) : 69-76.

Mormont M.C., Langouët AM., Claustrat B., Bogdan A., Marion S., Waterhouse J., Touitou Y., Lévi F. : Marker rhythms of the circadian system function : a study in patients with metastatic colorectal cancer and good performance status. Chronobiol. Int., 2002, 19 (1) : 141-156.

Mormont M.C., Waterhouse J. : Contribution of the rest-activity circadian rhythm to quality of life in cancer patients. Chronobiol. Int., 2002, 19 (1) : 313-323.

Filipski E., King V. M., Li X.M., Granda T. G., Mormont M.C., Liu X.H., Claustrat B., Hastings M. H., Lévi F. : Host circadian clock as a control point in tumor progression. J. Natl Cancer Inst., 2002, 94 (9) : 690-697.

Granda T.G., D’Attino R.M., Filipski E., Vrignaud P., Garufi C., Terzoli E., Bissery M.C., Lévi F. : Circadian optimization of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma. Brit. J. Cancer, 2002, 86 (6) : 999-1005.

Mormont M.C., Bogdan A., Cormont S., Touitou Y., Lévi F. : Cortisol diurnal variation in blood and saliva of patients with metastatic colorectal cancer : relevance for clinical outcome. Anticancer Res., 2002, 22 : 1243-1250.

Chevalier V., Curé H., Chollet P., Lévi F. : Phase II trial of chronomodulated infusion of high-dose fluorouracil and l-folinic acid. In reply. Letter. J. Clin. Oncol., 2002, 20 (18) : 3938-3939.

2003

Mormont M.C., Lévi F. : Cancer Chronotherapy : principles, applications and perspectives. Cancer, 2003, 97 : 155-169.

Lévi F., Mormont M.C. : Cancer Chronotherapy : Author reply. Cancer, 2003, 98 : 882-883.

Porsin B., Formento J.L., Filipski E., Etienne M.C., Francoual M., Renée N., Lévi F., Milano G. : Dihydropyrimidine dehydrogenase circadian rhythm in both enzyme activity and gene expression from mouse liver. Eur. J. Cancer, 2003, 39 (6) : 822-828.

Adam R., Huguet E., Azoulay D., Castaing D., Kunstlinger F., Lévi F., Bismuth H. : Hepatic resection after down-staging of unresectable hepatic colorectal metastases. Surg. Oncol. Clin. N. Am., 2003, 12 : 211-220.

Tanaka K., Adam R., Shimada H., Azoulay D., Lévi F., Bismuth H. : Role of neoadjuvant chemotherapy in the treatment of multiple colorectal metastases to the liver. Brit. J. Surg., 2003, 90 : 963-969.

Eriguchi M, Levi F, Hisa T, Yanagie H, Nonaka Y, Takeda Y. : Chronotherapy for cancer. Biomed Pharmacother., 2003, 57 Suppl 1 : 92s-95s.

2004

Wu M.W., Li X.M., Xian L.J., Lévi F. : Effects of meal timing on tumor progression in mice. Life Sciences, 2004, 75 : 1181-1193.

Wu M.W., Xian L.J., Li X.M., Innominato P., Lévi F. : Circadian expression of dihydropyrimidine dehydrogenase, thymidylate synthase, c-myc and p53 mRNA in mouse liver tissue. Chinese Journal of Cancer, 2004, 23 (3) : 235-242.

Filipski E., Lemaigre G., Liu X.H., Méry-Mignard D., Mahjoubi M., Lévi F. : Circadian rhythm of irinotecan tolerability in mice. Chronobiol. Int., 2004, 21 (4-5) : 613-630.

Li X.M., Beau J., Delagrange P., Mocaër E., Lévi F: circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J. Pineal Res., 2004, 37 : 176-184.
Filipski E., King V. M., Etienne M.C., Li X.M., Claustrat B., Granda T. G., Milano G., Hastings M. H., Lévi F.: Persistent circadian rhythms in liver and bone marrow despite suprachiasmatic nuclei ablation in mice. Am. J. Physiol., 2004, 287, R844-R851.

Hrushesky W., Wood P., Lévi F., von Roemeling R., Bjarnason G., Focan C., Cornelissen G., Halberg F. : A recent illustration of some essentials of circadian chronotherapy study design. J. Clin. Oncol., 2004, 22 (14) : 2971-2972.

Lévi F. : Editorial focus : PACAP enlightment of mouse circadian clock. Am. J. Physiol., 2004, 287: R1033-R1034. (Invité)

Filipski E., Delaunay F., King V.M., Wu M.W., Claustrat B., Gréchez-Cassiau A., Guettier C., Hastings M.H., Lévi F. : Effects of chronic jet lag on malignant growth in mice. Cancer Res., 2004, 64 (21) : 7879-7885.

Adam R., Delvart V., Pascal G., Valeanu A., Castaing D., Azoulay D., Giacchetti S., Brézeault-Bonnet C., Paule B., Kunstlinger F., Ghémard O., Lévi F., Bismuth H. : Rescue surgery for non-resectable colorectal liver metastases downstaged by chemotherapy : a model to predict long-term survival. Ann. Surgery, 2004, 240 (4) : 644-658.

Adam R., Pascal G., Castaing D., Azoulay D., Delvart V., Paule B., Lévi F., Bismuth H. : Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases ? Ann. Surg. 2004, 240 (6) : 1052-1064.

 

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