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Francis Lévi, Warwick Medical School, University of Warwick, July 21, 2014:

- Circadian control of xenobiotic carcinogenesis and cancer pharmacology

- Toward Systems Cancer Chronotherapeutics and its integration into home care 

La Société Francophone de Chronobiologie (SFC) organise son 44ème congrès qui se déroulera du 29-31 octobre 2014

Séance de la Société de Biologie " La chronobiologie " aura lieu le 15 octobre 2014 de 15h00 à 18h00 Institut Curie-Pavillon Curie Amphithéâtre Marie Curie 11, rue Pierre et Marie Curie – Paris 5ème

La soutenance de thèse de Melle Véronique ROCHE sera présentée le 21 mai 2014

Reportage BBC, 13 mai 2014  Chronotherapy: The science of timing drugs to our Body

Journal "Le monde" le 30 avril 2014, "Quand l'horloge biologique se détraque"


Voir la suite


UMRS 935

Equipe3 : Chronothérapie des cancers

et optimisation de la fonction hépatique

INSERM et Université Paris Sud

Bât A 3ème étage Campus CNRS
7 rue Guy Môquet
94801 Villejuif Cedex (France)
Tel :  +33 (0) 1 49 58 34 83
Fax : +33 (0) 1 49 58 34 59

Home Production scientifique Publication


Adam R, de Haas RJ, Wicherts DA, Vibert E, Salloum C, Azoulay D, Castaing D. : Concomitant extrahepatic disease in patients with colorectal liver metastases: when is there a place for surgery? Ann Surg. 2011, 253 (2) :349-359.

Adam R, Hoti E, Bredt LC. : Oncosurgical strategies for metastatic liver cancer. Cir Esp. 2011, 89 (1) :10-19.

Ahowesso C., Li X.M., Zampera S., Peteri-Brunbäck B., Dulong S., Beau J., Hossard V., Filipski E., Delaunay F., Lévi F. : Sex and dosing time dependencies in irinotecan-induced circadian disruption. Chronobiol. Int., 2011, 28(5): 458–470.

Altinok A., Gonze D., Lévi F., Goldbeter A. : An automaton model for the cell cycle. Interface Focus, 2011, 1: 36-47.

Artzrouni, M., Begg, C.B., Chabiniok, R., Clairambault, J., Foss, AJ.E., Hargrove, J., Lee, E.K., Siggers, J.H., Tindall, M. The First International Workshop on the Role and Impact of Mathematics in Medicine: A collective account. Amer. J. Transl. Res., 3(5): 492-497, 2011.

Azoulay D, Bhangui P, Andreani P, Salloum C, Karam V, Hoti E, Pascal G, Adam R, Samuel D, Ichai P, Saliba F, Castaing D. Short- and long-term donor morbidity in right lobe living donor liver transplantation: 91 consecutive cases in a European Center. Am J Transplant., 2011, 11 (1) :101-110.

Ballesta A., Dulong S., Abbara C., Cohen B., Okyar A., Clairambault J., Levi F. : A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery. PLOS Comput Biol., 2011, 7(9):e1002143.

Ballesta, A., Clairambault, J., Dulong, S., Lévi, F. : Theoretical Optimization of Irinotecan-based Anticancer Strategies in case of Drug-induced Efflux. Applied Mathematics Letters, 2011, 24 (7) : 1251-56.

Bhangui P, Vibert E, Majno P, Salloum C, Andreani P, Zocrato J, Ichai P, Saliba F, Adam R, Castaing D, Azoulay D. Intention-to-treat analysis of liver transplantation for hepatocellular carcinoma: Living versus deceased donor transplantation. Hepatology. 2011, 53 (5) :1570-1579.

Bouchahda M., Lévi F., Adam R., Rougier P. : Modern insights into hepatic arterial infusion for liver metastases from colorectal cancer. Eur. J. Cancer, 2011, 47 (2011) 2681–2690.

Bouchahda M., T. Macarulla, LIedo G., Lévi F., Elez M. E., Paule B., Karaboué A., Artru P., Tabernero J., Machover D., Innominato P., Goldschmidt E., Bonnet D., Ducreux M., Castagne V., Guimbaud R.: Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: A multicenter, retrospective analysis. Medical Oncology, 2011, 2011, 28 (Suppl 1) : 253-258.

Clairambault, J. Optimising cancer pharmacotherapeutics using mathematical modelling and a systems biology approach. Personalized Medicine, 2011, 8 (3) : 271-286.

Clairambault, J., Gaubert, S., Lepoutre, T. : Circadian rhythm and cell population growth. Mathematical and Computer Modelling, 2011, 53 : 1558-1567.

Clairambault, J. Commitment of mathematicians in medicine. A personal experience, and generalisations. Acta Biotheoretica, 59(3):201-211, 2011. doi:10.1007/s10441-011-9140-2.

de Haas RJ, Wicherts DA, Andreani P, Pascal G, Saliba F, Ichai P, Adam R, Castaing D, Azoulay D. Impact of expanding criteria for resectability of colorectal metastases on short- and long-term outcomes after hepatic resection. Ann Surg. 2011, 253(6):1069-1079.

Duclos-Vallée JC, Adam R, Vibert E, Samuel D. Reply. Hepatology. 2011, 53(5) :1778-1779.

Groheux D, Giacchetti S, Espié M, Rubello D, Moretti JL, Hindié E. Early monitoring of response to neoadjuvant chemotherapy in breast cancer with 18F-FDG PET/CT: defining a clinical aim. Eur J Nucl Med Mol Imaging. 2011, 38 (3): 419-425.

Groheux D, Giacchetti S, Moretti JL, Porcher R, Espié M, Lehmann-Che J, de Roquancourt A, Hamy AS, Cuvier C, Vercellino L, Hindié E. Correlation of high 18F-FDG uptake to clinical, pathological and biological prognostic factors in breast cancer. Eur J Nucl Med Mol Imaging, 2011, 38 (3): 426-435.

Innominato P., Giacchetti S., Moreau T., Smaaland R., Focan C., Bjarnason G., Garufi C., Iacobelli S., Tampellini M., Tumolo S., Carvalho C., Karaboué A., Levi F. : Prediction of survival by neutropenia according to delivery schedule of oxaliplatin-5-fluorouracil-leucovorin for metastatic colorectal cancer in a randomized international trial (EORTC 05963). Chronobiol. Int., 2011, 28 (7) : 586-600.

Koch M, Garden OJ, Padbury R, Rahbari NN, Adam R, Capussotti L, Fan ST, Yokoyama Y, Crawford M, Makuuchi M, Christophi C, Banting S, Brooke-Smith M, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Nimura Y, Figueras J, Dematteo RP, Büchler MW, Weitz J. Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery. Surgery. 2011, 149 (5):680-688.

Lehmann-Che J, Amira-Bouhidel F, Turpin E, Antoine M, Soliman H, Legres L, Bocquet C, Bernoud R, Flandre E, Varna M, de Roquancourt A, Plassa LF, Giacchetti S, Espié M, de Bazelaire C, Cahen-Doidy L, Bourstyn E, Janin A, de Thé H, Bertheau P. Immunohistochemical and molecular analyses of HER2 status in breast cancers are highly concordant and complementary approaches. Br J Cancer. 2011, 104 (11): 1739-1746.

Levi F., Mosekilde E., Rand D. A. : Advancing systems medicine and therapeutics through biosimulation. Interface Focus, 2011, 1: 3-6.

Lévi F., Okyar A. : Circadian clocks and drug delivery systems : impact and opportunities in chronotherapeutics. Exp. Opin. Drug Deliv. Editorial, 2011, 8(12):1535-1541 (Invité)

Lévi F., Altinok A., Goldbeter A. : Circadian rhythms and cancer chronotherapeutics In : Cancer Systems Biology, Bioinformatics and Medicine: Research and Clinical Applications, Frederick Marcus & Alfredo Cesario eds, Springer Dordrecht Heidelberg London New York, 2011, Chap. 15, Part 4, 381-407 (DOI: 10.1007/978-94-007-1567-7_15).

Lévi F., Karaboué A., Gorden L., Innominato P. F., Saffroy R.l, Giacchetti S., Hauteville D., Guettier C., Adam R., Bouchahda M. : Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability. Cancer Chemother. Pharmacol., 2011 Feb;67(2):339-48. doi: 10.1007/s00280-010-1327-8. Epub 2010 Apr 17..

Okyar A., Piccolo E., Ahowesso C., Filipski E., Hossard V., Guettier C., La Sorda R., Tinari N., Iacobelli S., Levi F. : Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum. Plos One, 2011, 6(6):e20393.

Özbay, H., Bonnet, C., Benjelloun, H., Clairambault, J. Stability analysis of cell dynamics in leukemia. Mathematical Modelling of Natural Phenomena, accepted, 2011.

Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, Koch M, Makuuchi M, Dematteo RP, Christophi C, Banting S, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Yokoyama Y, Fan ST, Nimura Y, Figueras J, Capussotti L, Büchler MW, Weitz J. Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011, 149 (5) :713-724.

Reyal F, Valet F, de Cremoux P, Mathiot C, Decraene C, Asselain B, Brain E, Delaloge S, Giacchetti S, Marty M, Pierga JY, Bidard FC. Circulating tumor cell detection and transcriptomic profiles in early breast cancer patients. Ann Oncol., 2011, 22(6) :1458-1459.

Scully C.G., Karaboué A., Liu W.M., Meyer J., Innominato P.F., Chon K.H., Gorbach A.M., Lévi F. : Skin surface temperature rhythms as potential circadian biomarkers for personalized chronotherapeutics in cancer patients. Interface Focus, 2011, 1:48-60.

Tincani G, Hoti E, Andreani P, Ricca L, Pittau G, Vitale V, Blandin F, Adam R, Castaing D, Azoulay D. Operative risks of domino liver transplantation for the familial amyloid polyneuropathy liver donor and recipient: a double analysis. Am J Transplant., 2011 11(4) :759-766.

Vibert E, Adam R. High intra-abdominal pressure during experimental laparoscopic liver resection reduces bleeding but increases the risk of gas embolism Br. J. Surg. 2011; 98: 845-852.

Vibert E, Duclos-Vallée JC, Ghigna MR, Hoti E, Salloum C, Guettier C, Castaing D, Samuel D, Adam R. Liver transplantation for hepatocellular carcinoma: the impact of human immunodeficiency virus infection. Hepatology. 2011, 53 (2) :475-482.

Wicherts D. A., deHaas R.J., Sebagh M., Saenz Corrales,E. Gorden D.L., Lévi  F., Paule B., Azoulay D., Castaing D., Adam R.: Impact of bevacizumab on functional recovery and histology of the liver after resection of colorectal metastases. Brit. J. Surg., 2011, 98(3): 399-407.

Wicherts D., De Haas R., Sebagh M., Ciacio O., Lévi F., Paule B., Giacchetti S., Guettier C., Azoulay D., Castaing D., Adam R., : Regenerative nodular hyperplasia of the liver related to chemotherapy: impact on outcome of liver surgery for colorectal metastases. Ann Surg Oncol. , 2011, 18(3): 659-669.



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