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Francis Lévi, Warwick Medical School, University of Warwick, July 21, 2014:

- Circadian control of xenobiotic carcinogenesis and cancer pharmacology

- Toward Systems Cancer Chronotherapeutics and its integration into home care 

La Société Francophone de Chronobiologie (SFC) organise son 44ème congrès qui se déroulera du 29-31 octobre 2014

Séance de la Société de Biologie " La chronobiologie " aura lieu le 15 octobre 2014 de 15h00 à 18h00 Institut Curie-Pavillon Curie Amphithéâtre Marie Curie 11, rue Pierre et Marie Curie – Paris 5ème

La soutenance de thèse de Melle Véronique ROCHE sera présentée le 21 mai 2014

Reportage BBC, 13 mai 2014  Chronotherapy: The science of timing drugs to our Body

Journal "Le monde" le 30 avril 2014, "Quand l'horloge biologique se détraque"

 

Voir la suite

Contact

UMRS 935

Equipe3 : Chronothérapie des cancers

et optimisation de la fonction hépatique

INSERM et Université Paris Sud

Bât A 3ème étage Campus CNRS
7 rue Guy Môquet
94801 Villejuif Cedex (France)
Tel :  +33 (0) 1 49 58 34 83
Fax : +33 (0) 1 49 58 34 59
Email:gladys.germe@inserm.fr

Home Production scientifique Publication

1977

Reinberg A., Lévi F., Guillet P., Nicolaï A., Dupont J.: Chronopharmacologic study of antihistaminic agents with special reference to terfenadine. Abstract 93, XII International Conference of the International Society for Chronobiology. Chronobiologia, 1977, 4: 142.

Reinberg A., Lévi F., Guillet P., Abulker C., Nicolai A.: Variations des effets d'un nouvel antihistaminique (la terfénadine) en fonction de l'heure de son administration. Communication à la Société Française d'Allergologie, séance du 10 Juin 1977.

1978  

Hrushesky W., Lévi F., Halberg F., Nelson W., Kennedy B.J.: Cisplatine chronotolerance. Proc. Conf. Combined Modalities: Chemotherapy/ Radiotherapy, abstract CP-V3, 1978, p. 58.

1979 

Lévi F., Ernsberger P., Cornelissen G., Taddeini L.: Potential marker rhythms of cisplatine (CisP) chronotoxicity: urine volume and core temperature. Ann. Congress Amer. Soc. Clin. Oncol. Proc. AACR/ASCO, 1979, 20: C512.

Lévi F., Hrushesky W., Halberg F., Kennedy B.J., Fortuny I.: Murine chronotolerance to cisPlatinum (CP) and its further optimization by hydration. Ann. Congress Amer. Assoc. Cancer Res., Proc. AACR/ASCO, 1979, 20:1112.

Hrushesky W., Lévi F., Fanning F., Halberg F., Kennedy B.J.: Chemotherapy (Rx) - associated changes in circadian parameters from thermorhythmometry over skin covering histological-validated cancer. Proc. Minn. Acad. Sci., 1979, p.14.

Lévi F., Halberg F.: Saline or short-chain-ACTH interactions with murine adriamycin (ADR) chronotolerance. Proc. Minn. Acad. Sci., 1979.

Bixby L., Lévi F., Haus E., Sackett L., Haus E., Halberg F., Hrushesky W.: Circaseptan aspects of cisPlatine (CP) murine nephrotoxicity. XV Int. Conf. of the Int. Soc. Chronobiology, Hannover, RFA. Chronobiologia, 1979, 6: 80.

Kennedy B.J., Lévi F., Hrushesky W., Culley D., Cornelissen G., Halberg E., Halberg F.: Circadian and circannual interactions with murine chronotolerance of cisPlatine (CP) with and without hydration. XV Int. Conf. of the Int. Soc. Chronobiology, RFA. Chronobiologia, 1979, 6: 117.

Hrushesky W., Pleasants M., Lévi F.,Borch R.F., Theologides A., Kennedy B.J.: Toward clinical chronotherapy: circadian chrono-pharmacokinetics of cisdiammine-dichloroplatinum in 5 patients with widely metastatic carcinoma. XV Int. Conf. of the Int. Soc. Chronobiology, RFA. Chronobiologia, 1979, 6: 113.

Lévi F., Pleasants M., Hrushesky W., Borch R.F., Halberg F.: Rat urinary chronopharmacokinetics of the antitumor drug cisPlatine (CP). XV Int. Conf. of the Int. Soc. Chronobiology, RFA. Chronobiologia, 1979, 6: 127.

1980

Lévi F., Halberg F., Cadotte L., Teslow T., Langevin T., Nelson W., Bazin H.: Survival time analysis reveals circannual rhythm in a host-tumor system-LOU rat immunocytoma. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979. Chronobiologia, 1980, 7: 128.

Sanchez S., Hrushesky W., Brown H., Halberg F., Sanchez E., Haus E., Lévi F., Kennedy B.J.: Circadian rhythm in RNA content of mononuclear cells from advanced cancer patients. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979.

Brown H., Hrushesky W., Sanchez S., Halberg F., Cornelissen G., Haus E., Lévi F., Theologides A., Kennedy B.J.: Intravenous chemotherapy increases the mesor and amplitude of the circadian rhythm in total leukocytes. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979.

Hrushesky W., Cornelissen G., Sanchez S., Brown H., Lévi F., Halberg F., Kennedy B.J.: Chemotherapy-associated acrophase-delay and amplitude-increase in circadian rhythm in tumor surface temperature in patients with advanced malignancy. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979.

Brown H., Lévi F., Halberg F., Haus E., Lakatua D., Melby J., Wilson T., Sothern R.B., Culley D., Berg H., Sanchez S., Hrushesky W., Scheving L.E.: Effects of a short-chain ACTH-17 (HOE 433) upon total and differential murine leukocyte counts. Proc. 3rd Conf. Ind. Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979.

Medini E., Lévi F., Halberg F., Hrushesky W., Haus E., Fanning R., Levitt S.: Circadian marker rhythmometry before and during chronoradiotherapy of a patient with extranodal lymphoma. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979.

Kawahara K., Lévi F., Halberg F., Cornelissen G., Sutherland D., Rynasiewick J., Goercki P., Najarian J.: Circaseptan bioperiodicity in rejection of heart and pancreas allografts in the rat. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979.

Hrushesky W., Sanchez S., Lévi F., Brown H., Halberg F., Haus E., Sothern R., Kennedy B.J.: Total RNA content of cancer patient's mononuclear cells demonstrated marked circadian rhythmicity. Proc. Am. Soc. Hematology, Blood, 54: 596, 1979.

Hrushesky W., Lévi F., Halberg F., Kennedy B.J.: Circadian variation in toxicity and efficacy of adriamycin (Ad) and platinum (DDP) alone and in combination. Proc. Minn. Soc. Int. Med., May, 1979.

Hrushesky W., Sanchez S., Lévi F., Halberg F., Kennedy B.J.: The RNA content of circulating mononuclear cells (MC) demonstrates marked circadian rhythmicity. Clin. Res., 1980, 28: 345 A.

Hrushesky W., Kubicek W., Lévi F., Olson M., Beck R., Bliss D., Sanchez S., Halberg F., Kennedy B.J.: Impedance cardiography (I.C.) detects adriamycin induced cardiac dysfunction. Clin. Res., 1980, 28: 416 A.

Lévi F., Lakatua D., Haus E., Hrushesky W., Halberg F., Schwartz S., Kennedy B.J.: Circadian urinary N-acetylglucominidase (NAG) excretion gauges murine cisdiamminedichloroplatinum (DDP), nephrotoxicity. Ann. Congress Amer. Ass. Cancer Res. Proc. AACR/ASCO, 1980, 21: 307, 1232.

Hrushesky W., Lévi F., Kennedy B.J.: Cis-diamminedichloroplatinum (DDP) toxicity to the human kidney reduced by circadian timing. Ann. Congress Am. Soc. Clin. Oncol. Proc. AACR/ASCO, 1980, 21: C45.

Halberg F., Lévi F., Chilhara F., Scheving L.E.: Chronobiologic intermodulation in immunology and neurophysiology. In: Proc. XXIII Conf. Physiol. Sci. Budapest, July 13-19, 1980, XIV: 458, 1694.

Lévi F., Halberg F., Hrushesky W., Kennedy B.J.: Chronobiology: an essential perspective for understanding apparent contradictions in immunotherapy. In: Proc. XIV Ann. Congress Am. Assoc. for Clin. Immunol. Allergy, Las Vegas, 1980, 4.

Hrushesky W., Lévi F., Sanchez S., Halberg F., Kennedy B.J.: Periodicity of human lymphocyte RNA content. In: Proc. XIV Ann. Cong. Amer. Assoc. for Clin. Immunol. Allergy., Las Vegas, 1980, 7.

Hrushesky W., Lévi F., Halberg F., Haus E., Langevin T., Frenning D., Theologides A., Kennedy B.J.: Reduced platinum renal toxicity by treatment based on biologic rhythms. Clin. Res., 1980, 28: 780 A.

Lévi F., Halberg F., Sanchez S., Sothern R., Hrushesky W., Langevin T., Haus E., Kennedy B.J.: Adriamycin tolerance improved by timed ACTH pretreatment. Clin. Res., 1980, 28: 780 A.

Lévi F., Halberg F., Cadotte L., Teslow T., Langevin T., Nelson W., Bazin H.: Survival time analysis reveals circannual rhythm in a host-tumor system-LOU rat immunocytoma. Proc. 3rd Conf. Indian Soc. Chronobiol., Varanasi, India, Dec. 27-29, 1979. Chronobiologia, 1980, 7: 128.

1981

Hrushesky W., Lévi F., Kennedy B.J., Theologides A., Frenning D.: Results of circadian time-qualified chemotherapy in patients with advanced ovarian cancer. Ann. Congress Amer. Soc. Clin. Oncol. Proc. AACR/ASCO, 1981, 22: C546.

Hrushesky W., Borch R., Lévi F., Langevin T., Lange P., Kennedy B.J.: Human urinary pharmacokinetics of cisplatin: role of circadian drug timing. Ann. Congress Amer. Soc. Clin. Oncol. Proc. AACR/ASCO, 1981, 22: C696.

Lévi F., Sanchez S., Hrushesky W., Bixby L., Haus E., Lakatua D., Halberg F., Kennedy B.J.: Adriamycin (ADR) cardiotoxicity: early assessment by creatine phosphokinase (CPK) isoenzymes. Ann. Congress Amer. Assoc. Cancer Res. Proc. AACR/ASCO, 1981, 22: 1029.

Lévi F., Hrushesky W., Halberg F., Langevin T., Kennedy B.J., Murry C.: Adriamycin (ADR) cardiotoxicity: tests of predictive value of circadian cardiovascular rhythm parameters. Ann. Congress Amer. Soc . Clin. Oncol. Proc. AACR/ASCO, 1981, 22: C126.

Lévi F., Hrushesky W., Holtzman J., Halberg F., Sanchez S., Kennedy B.J.: ACTH 1-17 raises cardiac reduced glutathione and protects mice from lethal cardiotoxicity. XIV Int. Cong. Int. Soc. Chronobiology, Minneapolis, USA. Int. J. Chronobiology, 1981, 7: 84.

Hrushesky W., Halberg F., Levi F., Langevin T., Kennedy B.J.: Circadian-circannual aspects of leucocyte count, depression and recovery in patients given doxorubicin and cis-diamminedichloroplatinum. XVI Int. Cong. Int. Soc. Chronobiology, Minneapolis, USA. Int. J. Chronobiol., 1981, 7:63.

Vukelich M., Hrushesky W., Halberg F., Langevin T., Lévi F., Kennedy B.J., Gergen J., Goetz F., Theologides A.: Elevated circadian mesor of pulse in recumbency predicts doxorubicin- induced congestive heart failure. XVI Int. Conf. Soc. Chronobiology, Minneapolis, USA. Int. J. Chronobiology, 1981, 7: 151.

Lévi F., Hrushesky W., Kennedy B.J.: Chronotolerance for cytostatic drugs in cancer treatment. In: Proc. XV ILAR.

Langevin T., Goetz F., Hrushesky W., Halberg F., Steiner B., Gergen J., Lévi F., Kennedy B.J.: Relative stability of urinary marker rhythms in cancer patients (CP) receiving intermittent nephrotoxicity chemotherapy. XVI Int. Soc. Chronobiology, Minneapolis, USA. Int. J. Chronobiology, 1981, 7: 82.

Hrushesky W., Vukelich M., Halberg F., Lévi F., Langevin T., Kennedy B.J., Gergen J., Goetz F., Theologides A.: Optimal circadian treatment time reduces cis-diamminedichloroplatinum (C)-induced vomiting. XVI Int. Conf. Int. Soc. Chronobiology, Minneapolis, USA. Int. J. Chronobiology,1981, 7: 64.

1982

Lévi F., Halberg F., Hrushesky W., Lakatua D., Haus E.: Selective timing improves heart tolerance for doxorubicin. Congrès de la Société Européenne de Médecine Oncologique. Cancer Chemother. Pharmacol., 1982, 9 (suppl.): 124.

Lévi F., Hrushesky W.: Chronopharmacologie du cisdiamminedichloroplatinum (cis-DDP, agent cytostatique) chez le Rat et l'Homme: chronesthésie du rein et chronopharmacocinétique urinari. Congrès Ann. du Groupe d'Etudes des Rythmes Biologiques (Paris), 1982.

Lévi F.: Rythmes de 7 jours en pharmacologie. R. Ann. Groupe d'Etudes des Rythmes Biologiques (Paris), 1982.

1983 

Lévi F., Blum J.P., Lemaigre G., Bourut C., Lapeyrague F., Belin J., Santelli G., Regensberg C., Castaing D., Houssin O., Musset M., Mathé G.: A 4-day subrenal capsule assay for evaluating the responsiveness of human tumors to anticancer drugs: a macroscopic and histologic evaluation. 74th Ann. Conf. Amer. Assoc. Cancer Res., San Diego USA. Proc. AACR/ASCO, 1983, 24: 1219.

Lévi F., Blum J.P., Lemaigre G., Bourut C., Misset J.L., Mathé G.: Need for a histopathological assessment of anticancer drug effectiveness in the subrenal capsule assay of human tumors. Int. Symp. on Predictive Drug Testing on Human Tumor Cells. Zurich, 1983. Int. J. Cell Cloning, 1983, 1: 288.

Blum J.P., Lévi F., Lemaigre G., Bourut C., Mathé G.: Subrenal capsule assay of human tumors: comparison of morphometry and histology without treatment. In: Int. Symp. on Predictive Drug Testing on Testing on Human Tumor Cells, Zurich, 1983, Int. J. Cell Cloning, 1983, 1: 300.

Ribaud P., Gouveia J., Dorval T., Misset J.L., Machover D., Lévi F., Blum J.P., Maral R., Mathé G.: Phase I study of dichloroethyl nitrosourea-N, N cystamine (CNCC). Ann. Cong. Amer. Assoc. Clin. Oncol. Proc. ASCO,1983, 2: C170.

Reinberg A., Lévi F., Fourtillan J.P., Peiffer C., Bicakova-Rocher A.: Circadian changes in antihistamine effects as well as pharmacokinetics of mequitazine in man. XVI Int. Conf. Int. Soc. Chronobiology, Dublin, 1983, Chronobiologia, 1983, 10: 111.

Lévi F., Le Louarn C., Simon L., Peltier A., Reinberg A.: Chronotherapy of ostheoarthritic patients with a sustained-release preparation of indomethacin: group and individualized drug optimization. XVI Int. Conf. Int. Soc. Chronobiology, Dublin, 1983, Chronobiologia, 1983, 10: 82.

Hallek M., Reinberg A., Schmid R., Lévi F., Hellbrugge T.: Circadian and ultradian rhythms in behaviour and seizures of children with petit mal epilepsy. XVI Int. Conf. Int. Soc. Chronobiology, 1983, Chronobiologia, 1983, 10: 61.

Lévi F.: Xenograft test for prediction of tumor chemosensitivity. Rapport Colloque Franco-Japonais sur les anthracyclines, Villejuif, 5-6 Sept. 1983.

Reinberg A., Haus E., Lévi F.: Chronobiologie, chronopharmacologie et hématologie. Rapport séance plénière. VII ème Cong. Soc. Fr. Hématologie, Limoges, Nouv. Rev. Fr. Hématol., 25: 5-25, 1983.

Lévi F.: Chronopharmacology of anthracyclines. Rapport Colloque Franco-Japonais sur les anthracyclines, Villejuif, 5-6 Sept. 1983.

Reinberg A., Andlauer P., Benoît O., Lévi F., Philbert M.: Chronobiologie et travail posté. Rapport Entretien de Bichat, 15 Sept. 1983.

Lévi F., Blum J.P., Lemaigre G., Bourut C., Mechkouri M., Roulon A., Mathé G.: A 4-day subrenal capsule assay for testing the effectiveness of anticancer drugs against tumors. Proc. 2nd Europ. Conf. on Clin. Oncol. Cancer Nurs., Amsterdam, 2-5 Nov. 1983: 12-18.

Lévi F.: Infection, immunomodulation et chronobiologie. Rapport 2ème séminaire de Physiopathologie des Maladies Infectieuses: "Antibiotiques: limites et thérapeutiques complémentaires". Université Libre de Bruxelles, Bruxelles 3 Déc. 1983.

1984

Lévi F., Blum J.P., Lemaigre G., Mechkouri M., Roulon A., Bourut C., Hacpille L., Reinberg A., Mathé G.: Chronopharmacology: a critical stage in the development of new anticancer drugs? THP adriamycin as an example. Ann. Cong. Amer. Assoc. Cancer Res. Proc. AACR, 1984, 25: 1216.

Lévi F., Canon C., Blum J.P., Misset J.L., Mechkouri M., Reinberg A., Florentin I., Mathé G.: Calla + lymphocyte (L) number varies 100 fold along the 24 hour scale in healthy subjects. Physiological circadian variations in 6 lymphocyte subpopulations . Ann. Cong. Amer. Cancer Res. Proc. AACR, 1984, 25: 945.

Lévi F., Canon C., Blum J.P., Misset J.L., Bennaceur M., Mathé G.: Circadian rhythms of six circulating lymphocyte subtypes in healthy men: a 100-fold variation may be physiologic. 1st Int. Cong. Chronopharmacology, Montreux, 1984.

Lévi F., Le Louarn C., Reinberg A.: Chronotherapy of osteoarthritic patients: optimization of indomethacin sustained release (ISR). 1st Int. Cong. Chronopharmacology, Montreux, 1984.

Lévi F., Blum J.P., Lemaigre G., Mechkouri M., Roulon A., Reinberg A., Mathé G.: Chronopharmacology: a critical stage in the development of new anticancer drugs? THP adriamycin as an example. 1st Int. Cong. Chronopharmacology, Montreux, 1984.

Reinberg A., Lévi F., Bicakova-Rocher A., Blum J.P., Ouechni M., Nicolaï A.: Biologic time-related changes in antihistamine and other effects of chronic administration of mequitazine in healthy adults. 1st Int. Cong.Chronopharmacology, Montreux, 1984.

Reinberg A., Lévi F., Fourtillan J.P., Peiffer C., Bicakova-Rocher A., Nicolaï A.: Antihistamine and other effects of 5 mg mequitazine vary between morning and evening acute administration. 1st Int. Cong. Chronopharmacology, Montreux, 1984.

Lévi F., Blum J.P., Lemaigre G., Mathé G.: A histologic evaluation of the four day subrenal capsule assay. Rapport Int. Cong.of Cytology and Histochemistry, Helsinky, Finland, 1984.

Lévi F., Canon C., Blum J.P., Vannetzel J.M., Mechkouri M., Reinberg A., Mathé G.: Circadian rhythms in circulating lymphocytes subtypes in healthy men. 10th Ann. Cong. Europ. Soc. Clin. Oncol., Nice 1983. Cancer Chemother. Pharmacol., 1984.

Blum J.P., Lévi F., Mechkouri M., Roulon A., Santus R., Reinberg A., Mathé G.: Murine tolerance for etoposide (VP 16 213) depends upon its time of administration . 10th Ann. Cong. Europ. Soc. Clin.Oncol., Nice, 1983. Cancer Chemother. Pharmacol., 1984.

Reinberg A., Lévi F., Smolensky M.: Chronopharmacocinétique clinique. Rapport séance plénière. 36ème Actualités Pharmacologiques. Pharmacologistes de Langue Française .J. Pharmacologie (Paris), 1984 (suppl. 1): 95-124.

Lévi F.: Principes chronothérapeutiques. Xème Congrès de la Soc. Intern. Rech. Mal. Civil. Environ., Paris, 16 Nov. 1984.

Lévi F.: Chronothérapeutique en allergologie. Rapport R. Ann. Soc. Française d'Allergologie, Paris, 16 Juin 1984.

Lévi F.: Chronobiologie et chimiothérapie. R. Ann. Soc. Française Exp. Animale, Chatenay-Malabry, 18 Mai 1984.

1985

Lévi F., Bailleul F., Mechkouri M., Roulon A., Misset J.L., Reinberg A., Mathé G.: Major optimization of hematologic tolerance for 4'-0-tetrahydropyranyl (THP) adriamycin with early morning administration. 76th Annual Meeting of the Ann. Ass. for Cancer Res., Houston (Texas, USA), 22-25 Mai 1985, Proc. AACR, 1985, 265: 642.

Lévi F., Canon C., Mechkouri M., Bennaceur M., Vannetzel J.M., Touboul J. P., Reinberg A., Mathé G.: Circannual modulation of circadian rhythm in circulating lymphocyte subsets in man. XVII Int. Conf. Intern. Soc. Chronobiology, Little Rock (Arkansas, USA), 3-6 Novembre 1985. Chronobiologia, 1985, 12:59.

Bailleul F., Lévi F., L'Helgoualch G., Reinberg A., Mathé G.: Seasonal trends in diagnosis, relapse and mortality rates from human breast cancer. XVII Int. Conf. Intern. Soc. Chronobiology, Little Rock (Arkansas, USA), 3-6 Novembre 1985, Chronobiologia, 1985, 12:3.

Reinberg A., Gervais P., Smolensky M., Lévi F., Ugolini C., Del Corro L.: Chronoepidemiologic study of allergic rhinitis. XVII Int. Conf. Intern. Soc. Chronobiology, Little Rock (Arkansas, USA) 3-6 Novembre 1985, Chronobiologia, 1985, 12:87.

Reinberg A., Pauchet F., Smolensky M., Ruff F., Gervais P., Lévi F., Chaouat D., Abella M.L.: Once a day (0800 vs 2000) theophylline dosing (10 mg/kg/24h; 8 days) does not shift the circadian acrophase of 5 physiologic variables in 8 adult subjects. XVII Int. Conf. Intern. Soc. Chronobiology, Little Rock, (Arkansas, USA), 3-6 Novembre 1985, Chronobiologia, 1985, 12:88.

Lévi F.: Chronopharmacology of anticancer agents. "Chronopharmacology and Chronotherapy". Table Ronde Roussel-Uclaf, n° 54, Paris, 12-13 Décembre 1985.

Lévi F.: Moyens d'investigations de la chronesthésie. 2ème Réunion du Groupe Français de Chronopharmacologie, Aussois (France), 24-28 Sept. 1985.

Lévi F.: Optimisation chronothérapeutique: groupe ou individu? 2ème Réunion du Groupe Français de Chronopharmacologie, Aussois (France), 24-28 Sept. 1985.

Lévi F., Bailleul F., Reinberg A., Mathé G.: Chronopharmacologie de la THP - adriamycine. Groupe Français des Anthracyclines., Paris, 3 Oct. 1985.

Kottler M. L., Coussieu C., Valensi P., Lévi F., Sebaoun J., Pegrelle H.: Variations nycthémérales de la concentration plasmatique de la progestérone et de LH chez la femme normale en phase lutéale. Vème Congrès Français d'Endocrinologie, Bordeaux, 3-5 Oct. 1985.

Lévi F., Bailleul F., Mechkouri M., Roulon A., Reinberg A., Mathé G.: Chronobiologie et cancérologie. Journée de la Recherche, Université du Kremlin - Bicêtre, Paris, 21 Nov. 1985.

Decousus H., Croze M., Lévi F., Jaubert J., Perpoint B., Reinberg A., Queneau P.: Variation nycthémérale de l'effet anticoagulant de l'héparine perfusée par voie intraveineuse continue à débit constant. Soc. Fr. Pharmacol. Clin., Nantes 31 Mai - 1er Juin 1985.

Decousus H., Ollagnier M., Cherrach Y., Lévi F., Perpoint B., Queneau P.: Chronocinétique du kétoprofène perfusé par voie intraveineuse continue à débit constant. Réunion Ass. des Pharmacol. de Langue Franç., Grenoble, Avril 1985.

1986

Lévi F., Bailleul F., Misset J.L., Chevelle C., Le Saunier P., Vannetzel J. M., Despax R., Machover D., Ribaud P., Reinberg A., Mathé G.: Clinical chronopharmacologic optimization of hematologic tolerance for the anticancer agent 4'-0-tetrahydropyranyl adriamycin (THP). Proc. 2nd Int. Conf. of Biological Rhythms and Medications. Montreux (10-13 Mars 1986).

Ferle-Vidovic A., Blazsek I., Lévi F.: Circadian time dependence of murine bone marrow tolerance for the anticancer agent 4'-0-tetrahydropyranyl adriamycin (THP). Proc. 2nd Intern. Conf. of Biological Rhythms and Medications, Montreux (10-13 Mars 1986).

Lévi F., Bailleul F., Metzger G., Misset J. L., Vannetzel J. M., Regensberg C., Reinberg A., Mathé G.: Adriamycin chronotherapy of advanced breast cancer with a programmable implantable drug administration device. Proc. 2nd Intern. Conf. of Biological Rhythms and Medications, Montreux (10-13 Mars 1986).

Lévi F., Bailleul F., Misset J. L., Chevelle C., Le Saunier F., Despax R., Vannetzel J. M., Machover D., Reinberg A., Mathé G.: Large improvement of hematologic and renal tolerance for THP and CDDP at selected dosing times in patients with ovarian cancer. Proc. Am. Ass. Clin. Oncol., 1986, 5: 190.

Lévi F., Metzger G., Bailleul F., Reinberg A., Mathé G.: Circadian-varying plasma pharmacokinetics of doxorubicin (DOX) despite continuous infusion at constant rate. Proc. Am. Ass. Cancer Res., 1986, 27: 693.

Lévi F., Blaszek I., Bailleul F., Lahaye R., Mechkouri M., Misset J. L., Reinberg A., Mathé G.: Individualized chronotherapy of cyclic granulocytic leukemia (CGL) with hydroxyurea (HU). Proc. 21st Congress Intern. Soc. Hematol., (Sydney, Austr., 11-13 Mai 1986), M132.

Lévi F., Bailleul F., Misset J. L., Chevelle C., Le Saunier F., Despax R., Vannetzel J. M., Machover D., Reinberg A., Mathé G.: Chrono-optimisation majeure de la tolérance hématologique et rénale à l'association de 4'-tetrahydropyranyladriamycine (THP) et de cisplatine chez des femmes atteintes de cancer de l'ovaire. Symposium Anthracyclines, (Marrakech, Maroc, 29-30 Mai 1986).

Lévi F.: Timing of therapy. Boerhaave Commissie voor Postacademish Onderwijs in de Geneeskunde (Leiden, Hollande, 12-13 Juin 1986).

Lévi F., Bailleul F., Metzger G., Reinberg A., Mathé G.: Chronotherapy of human breast cancer with doxorubicin (DOX) via implantable programmable drug administration device (DAD). 5ème Congrès Intern. Cardiostim 86 (Monte-Carlo, 19-21 Juin 1986).

Lévi F.: Preclinical chronotoxicologic studies of new cytostatic compounds. 14th Int. Cancer Congress (Budapest, Hongrie, 21-27 Août 1986).

Lévi F., Horvath C., Lemaigre G., Mechkouri M.,Roulon A., Bailleul F., Reinberg A., Mathé G.: Circadian rhythm in murine tolerance for peptichemio (PTC). 14th Int. Cancer Congress (Budapest, Hongrie, 21-27 Août 1986).

Bailleul F., Lévi F., Misset J. L., Le Saunier F., Chevelle C., Despax R., Vannetzel J. M., Machover D., Regensberg C., Reinberg A., Mathé G.: Clinical optimization of renal tolerance for cisdichlorodiammineplatinum (CDDP) by late afternoon dosing. 14th Int. Cancer Congress, (Budapest, Hongrie, 21-27 Août 1986).

Bailleul F., Berger V., Lévi F., Reinberg A., Mathé G.: Seasonal variations in incidence data of human breast cancer with poor prognosis factors. 12ème Congrès de la Soc. Europ. de Médecine Interne Cancérologique (Nice, 28-30 Novembre 1986). Cancer Chemother. Pharmacol., 1986 (suppl. 1).

Lévi F., Bailleul F., Le Saunier F., Benavides M., Chevelle C., Misset J. L., Regensberg C., Machover D., Despax R., Ribaud P., Reinberg A., Jasmin C.: Chronotherapy of ovarian cancer with THP and CDDP. A comparative phase II trial. 12ème Congrès de la Soc. Europ. de Médecine Interne Cancérologique (Nice, 28-30 Nov. 1986). Cancer Chemother. Pharmacol., 1986, (suppl. 1).

Canon C., Lévi F., Bennaceur M., Touboul J. P., Pati A., Reinberg A., Mathé G.: Alterations of circadian rhythms in lymphocyte subpopulations of patients with hematologic malignancies. 12ème Congrès de la Société Européenne de Médecine Interne Cancérologique (Nice, 28-30 Nov. 1986). Cancer Chemother. Pharmacol., 1986 (suppl. 1).

Lévi F.: Chronotherapia de las canceres: utilizacion de bombas programmables. 1er Symposio Internacional Chronobiologia, Chronopharmacologia y perspectivas therapeuticas(Madrid, Espagne, 12 Nov. 1986).

Lévi F.: Propriétés des rythmes biologiques. Conséquences pour les études des anticancéreux.Journée d'Etude de la Société Française d'Expérimentation Animale, Gif-sur-Yvette, 5 Déc. 1986.

Lévi F.: Approche chronobiologique de la fatigue. 2ème Colloque National sur l'asthénie, Paris, 11 Décembre 1986.

1987

Lévi F.: Propriétés des rythmes biologiques. Conséquences pour les études des anticancéreux.Journée d'Etude de la Société Française d'Expérimentation Animale, Gif-sur-Yvette, 5 Déc. 1986.

Lévi F.: Approche chronobiologique de la fatigue. 2ème Colloque National sur l'asthénie, Paris, 11 Décembre 1986.

Boughattas A., Lévi F., Roulon A., Mechkouri M., Lemaigre G., Cal J. C., Cambar J., Reinberg A., Mathé G.: Similar circadian rhythm in murine host tolerance for two platinum analogs: carboplatin (CBDCA) and oxaliplatin (l-OHP). 78th Ann. Meeting Amer. Assoc. Cancer Res. ,Atlanta (USA), May 20-23 1987. Proc. AACR, 1987, 28: 1788.

Bailleul F., Lévi F., Metzger G., Regensberg C., Reinberg A., Mathé G.: Chronotherapy of advanced breast cancer with continuous doxorubicin infusion via an implantable programmable device. 78th Ann. Meeting Amer. Assoc. Cancer Res., Atlanta (USA), May 20-23 1987. Proc. AACR, 1987, 28: 771.

Lévi F., Bailleul F., Chevelle C., Benavides M., Misset J. L., Le Saunier F., Despax R., Ribaud P., Machover D., Jasmin C., Regensberg C. , Reinberg A., Mathé G.: Chronotherapy of ovarian cancer with 4'-tetrahydropyranyladriamycin (THP) and cisdichloroplatinum. 23 rd Ann. Meeting Am. Soc. Clin. Oncol., Atlanta (USA), May 17-19 1987. Proc. ASCO, 1987, 6: 467.

Bailleul F., Lévi F., Touitou Y., Touboul J. P., Reinberg A., Mathé G.: Desynchronization of hematologic and cortisol circadian rhythms in cancer patients with poor performance status. Proc. XVIII Int. Conf. Intern. Soc. Chronobiology, Leyden (Holland), July 12-17 1987. Chronobiologia, 1987, 19:150.

Viret J., Bailleul F., Testylier G., Lévi F.: Circadian variations in acetylocholinesterase (ACHE) activity from murine brain. Proc. XVIII Int. Conf. Intern. Soc. Chronobiology, Leyden (Holland), July 12-17 1987. Chronobiologia, 1987, 19: 150.

Touitou Y., Lévi F., Ferment O., Bailleul F., Bogdan A., Auzeby A., Chevelle C., Le Saunier F.: CA 125 rhythmicity in ovarian cancer patients. Effects of chemotherapy. Proc. XVIII Int. Conf. Int. Soc. Chronobiol., Leyden (Holland), July 12-17 1987. Chronobiologia, 1987, 19: 236.

Motohashi Y., Reinberg A., Bourdeleau P., Benoît O., Lévi F., Nouguier J., Touitou Y.: Internal desynchronization of 9 circadian rhythms documented longitudinally in subjects with good and poor tolerance to shift work. Proc. XVIII Int. Conf.Intern. Soc. Chronobiology, Leyden (Holland), July 12-17 1987. Chronobiologia, 1987, 19: 213.

Lévi F., Roulon A., Mechkouri M., Bailleul F., Reinberg A., Mathé G.: Strain-associated differences in circadian rhythm of tolerance of mice for 4'-tetrahydropyranyladriamycin (THP). Proc. XVIII Int. Conf. Intern. Soc. Chronobiology, Leyden (Holland), July 12-17 1987. Chronobiologia, 1987, 19: 177.

Lévi F.: Automatized chronotherapy of cancers via programmable drug delivery systems. Proc. Infu-Systemes , Sophia-Antipolis, France, Sept. 1987, 7-72.

Petit E., Milano G., Lévi F., Thyss A., Schneider M., Bailleul F.: Chronopharmacocinétique du 5-FU en administration continue. Proc. Infu-Systemes, Sophia-Antipolis, France, Sept. 1987, 9-13.

Boughattas A., Lévi F., Lemaigre G., Roulon A., Hecquet B., Mechkouri M., Reinberg A., Mathé G.: Circadian and seasonal changes in host tolerance and tissue distribution of oxaliplatin (l-OHP) in mice. Proc. 4th Eur. Conf. Clin. Oncol., 1987, 329.

Lévi F., Adam R., Benavides M., Bailleul F., Soussan A., Misset J. L., Burki F., Reinberg A., Smolensky M., Bismuth H., Mathé G.: Ambulatory 5-day chronotherapy of colorectal or pancreatic cancer with continuous venous infusion of 5-fluorouracil (CVI - 5FU) at circadian-modulated rate. A phase I - II trial . Proc. 4th Europ. Conf. Clin. Oncol., 1987, 184.

Petit E., Milano G., Lévi F., Thyss A., Bailleul F., Schneider M.: Circadian rhythm in 5-FU pharmacokinetics during 5-day continuous infusion. Proc. 4th Europ. Conf. Clin. Oncol., 1987, 293.

Marino J. P., Brienza S., Dantchev D., Misset J. L., Musset M., De Vassal F., Machover D., Goldschmidt E., Ribaud P., Lévi F., Despax R., Mathé G.: Reduced toxicity of THP-adriamycin in cancer patients.Proc. 4th Europ. Conf. Clin. Oncol., 1987, 310.

Lévi F.: Chronopharmacologie des agents anticancéreux et chronothérapeutique des cancers. 19ème Congrès Annuel du Groupe d'Etude des Rythmes Biologiques, Paris 29-30 Janvier 1987.

Boughattas A., Lévi F.: Chronotolérance circadienne de la souris à deux agents anticancéreux: l'oxaliplatine (l-OHP) et le carboplatine (CBDCA). 19ème Congrès Annuel du Groupe d'Etude des Rythmes Biologiques, 29-30 Janvier 1987.

Lévi F.: Chronopharmacologie des anthracyclines. Conséquences cliniques. 6ème Réunion du Groupe Français des Anthracyclines, Paris, 12 Mars 1987.

1988

Pati A., Florentin I., Lemaigre G., Mechkouri M., Lévi F.: Chronopharmacologic optimization of ciclosporin A in mice. Proc. 3rd Int. Conf. Chronopharmacology, 14-17 Mars 1988, Nice, France, Ann. Rev. Chronopharmacol., 1988, 5: 43.

Lévi F., Adam R., Soussan A., Caussanel J. P., Benavides M., Misset J. L., Burki F., Reinberg A., Smolensky M., Bismuth H., Mathé G.: Ambulatory 5-day chronotherapy of colorectal or pancreatic cancer with continuous venous infusion of 5-fluorouracil at circadian-modulated rate. Preliminary results. Proc. 3rd Int. Conf. Chronopharmacology, 14-17 Mars 1988, France, Ann. Rev. Chronopharmacol., 1988, 5: 419-422.

Lévi F., Pati A., Florentin I., Chung V., Lemaigre G., De Sousa M., Berardet M., Mechkouri M.: Chronopharmacologic optimization of oral ciclosporin A in mice. 79th Ann. Meet. Am. Ass. Cancer Res. Proc. AACR, 1988, 29: 1728.

Boughattas A. N., Lévi F., Lemaigre G., Hecquet B., Roulon A., Reinberg A., Mathé G.: Circadian rhythm in lethal, intestinal and hematologic tolerance for carboplatin in mice. 79th Ann. Meet. Am. Assoc. Cancer Res. Proc. AACR, 1988, 29: 1369.

Levi F., Adam R., Soussan A., Caussanel J. P., Benavides M., Misset J. L., Kunstlinger F., Descorps-Declère A., Reinberg A., Bismuth H., Mathé G.: Ambulatory 5-day chronotherapy of colorectal cancer with continuous venous infusion of 5-fluorouracil at circadian-modulated rate. 24th Ann. Meeting Am. Soc. Clin. Oncol. Proc. Am. Soc. Clin. Oncol., 1988, 29: 1369.

Focan C., Mazy V., Metzger G., Lévi F., Bruguerolle B., Zhou J., Romain R., Cano J. P.: Circadian variability of vindesine serum concentration during continuous infusion. Proc. Int. Cong. Cardiostim 88, Monaco, 15-18 Juin 1988, PACE 1988, 11, suppl. 970 (719/719).

Caussanel J. P., Lévi F., Misset J. L., Mathé G.: Chronotherapy of patients with metastatic colorectal cancer with 5-fluorouracil and oxaliplatin automatically-delivered via a programmable external pump. Preliminary results. Proc. 6th Int. Cong. Cardiostim 88, Monaco, 15-18 Juin 1988, PACE 1988, 11 (suppl.), 970 (718/618).

Burki F., Benavides M., Regensberg C., Lévi F., Musset M., Misset J. L., Mathé G.: Intraperitoneal chemotherapy in advanced carcinoma. Proc. UICC Workshop "Progress in Regional Cancer Therapy I" , Vienne, Autriche, 3-5 Nov. 1988, 121.

Bourin P., Mansour J., Eono P., Lévi F., Mechkouri M., Doinel C.: Circadian rhythms in HIV-infected patients: alteration of monocyte and lymphocyte subsets. Bas. Appl. Histochem., 1988, 32: 341.

Benavides M., Burki F., Lévi F., Regensberg C., Misset J. L., Mathé G.: Intraperitoneal chemotherapy as consolidation treatment for stage III-IV ovarian cancer. A pilot study of efficacy and tolerance. Proc. 13th Conf. Europ. Soc. Med. Oncol., Lugano (Suisse), 28-31 Oct. 1988.

Lévi F., Benavides M., Misset J. L., Reinberg A., Mathé G.: Chronopharmacologie d'une nouvelle anthracycline, la 4' - tetrahydropyranyladriamycine (THP). Validation clinique du modèle expérimental. 4ème Journée de Pharmacologie Clinique, Paris, 24 Juin 1988. Thérapie, 1988, 43: 515.

Caussanel J. P., Lévi F., Adam R., Misset J. L., Jasmin C., Bismuth H., Reinberg A., Mathé G.: Chronothérapie par oxaliplatine (l-OHP) en perfusion continue de cinq jours. Résultats préliminaires d'une étude comparative. 2èmes Journées de Pharmacocinétique Clinique Oncologique, Lille, 20-21 Oct. 1988.

Boughattas N. A., Lévi F., Fournier O., Lemaigre G., Roulon A., Hecquet B., Reinberg A.: Rythmes circadiens de la toxicité et de la pharmacocinétique de trois complexes de platine (CDDP, CBDCA et l-OHP) chez la souris. 2èmes Journées de Pharmacocinétique Clinique Oncologique, Lille, 20-21 Oct. 1988.

Focan C., Doalto L., Mazy V., Rhamani R., Lévi F., Bruguerolle B., Hecquet B., Cano J. P.: Vindésine en perfusion continue de 48 heures (suivie de cisplatine): données chronopharmacocinétiques et efficacité clinique dans le cancer pulmonaire avancé. 27èmes Journées de Pharmacocinétique Clinique Oncologique, Lille, 20-21 Oct. 1988.

1989

Caussanel J. P., Lévi F., Misset J. L., Jasmin C., Reinberg A., Mathé G.: Five-day continuous venous infusion (CVI) of oxaliplatin (l-OHP) via ambulatory programmable pumps: does circadian modulation of infusion rate affect dose intensity? Proc. 6th NCI - EORTC Symposium on new drugs in cancer therapy, Amsterdam, The Netherlands, March 7-10 1989, abst. 208.

Boughattas A. N., Lévi F., Lemaigre G., Roulon A., Leclerc A., Mechkouri M., Reinberg A., Mathé G.: Similar circadian optimization of hematologic tolerance for cisplatin (CDDP) or carboplatin (CBDCA) following single or multiple dosing in mice. Proc. 6th NCI-EORTC Symposium on new drugs in cancer therapy, Amsterdam, The Netherlands, March 7-10 1989, abst. 230.

Lévi F., Soussan A., Adam R., Caussanel J. P., Metzger G., Misset J. L., Descorps-Declères A., Kunstlinger F., Lorphelin D., Jasmin C., Bismuth H., Reinberg A., Mathé G.: Programmable-in-time pumps for chronotherapy of patients (pts) with colorectal cancer with 5-day circadian-modulated venous infusion of 5-fluorouracil (CVI - 5 FUra). Proc. ASCO, San Francisco, USA, 1989, 8: 111 (abst. 429).

Boughattas N., Lévi F., Lemaigre G., Roulon A., Reinberg A., Mathé G.: Large circadian optimization of murine tolerance for cisplatin (CDDP) or carboplatin (CBDCA) following multiple dosing. Proc. AACR, San Francisco, USA, 1989, 30: 471 (abst. 1873).

Hrushesky W. J. M., Sothern R. B., Lévi F., Olshefski R., Lannin D., Beretska J. S., Gruber S. A.: Circadian timing, anatomic location and dose of tumor cell inoculum each affect tumor biology. Proc. AACR, San Francisco, USA, 1989, 30: 82 (abst. 323).

Lévi F., Caussanel J. P., Adam R., Metzger G., Kunstlinger F., Lorphelin J. M., Bismuth H., Reinberg A., Misset J. L., Mathé G.: Automatized circadian chronotherapy of metastatic colorectal cancers with 5-fluorouracil (5-FUra), folinic acid (FOL) and oxaliplatinum (l-OHP). Proc. 16th Int. Cong. Chemother., Jerusalem, Israël, 1989: 174.

Lévi F., Caussanel J. P., Metzger G., Lefebvre A., Reinberg A., Misset J. L., Mathé G.: Circadian-modulated infusion rate of anticancer drugs: rationale and preliminary results. Proc. 16th Int. Cong. Chemother., Jerusalem, Israël, 1989: 169.

Marino J. P., Brienza S., Benavides M., Dantchev D., Misset J. L., Musset M., De Vassal F., Goldschmidt E., Ribaud P., Lévi F., Despax R., Pappo E., Mathé G.: Minimal clinical cardiotoxicity of THP - adriamycin. Proc. 16th Int. Cong. Chemother., Jerusalem, Israël, 1989, 208.

Lévi F., Caussanel J. P., Adam R., Metzger G., Kunstlinger F., Lorphelin J. M., Bismuth H., Reinberg A., Misset J. L., Mathé G.: Automatized circadian chronotherapy of metastatic colorectal cancers with 5-fluorouracil (5-FUra), folinic acid (FOL) and oxaliplatinum (l-OHP). Proc. XIXth Int. Conf. of the Int. Soc. Chronobiol., Bethesda, USA, Chronobiologia, 1989, XVI (2): 154-155.

Lévi F., Roulon A.: Circadian rhythm in antitumor effectiveness of 4'-tetrahydropyranyladriamycin (THP) in mice. Proc. XIXth Int. Conf. of the Int. Soc. Chronobiology, Bethesda, USA. Chronobiologia, 1989, XVI (2): 155.

Lévi F., Caussanel J. P., Adam R., Soussan A., Metzger G., Misset J. L., Goldberg J., Descorps-Declère A., Jasmin C., Bismuth H., Reinberg A., Mathé G.: Ambulatory circadian chronotherapy of patients (pts) with gastro-intestinal (G. I.) cancers with external programmable pumps. World Congress on Home Care, Rome, Italie, 14-18 Mars 1989.

Caussanel J. P., Lévi F., Adam R., Metzger G., Kunstlinger F., Lorphelin J. M., Bismuth H., Reinberg A., Misset J. L., Mathé G.: Automatized circadian chronotherapy of metastatic colorectal cancers with 5-fluorouracil (5-FUra), folinic acid (FOL) and oxaliplatinum (l-OHP). Congrès International - La chimiothérapie en perfusion continue, Bordeaux, France, 21-22 Avril 1989.

Lévi F., Focan C.: A multicenter cooperative group for evaluating the clinical benefits of cancer chronotherapy: the Cancer Group from the Association for Medical Chronobiology (ACM). Congrès International - La chimiotherapie en perfusion continue. Bordeaux, France, 21-22 Avril 1989.

Caussanel J. P., Lévi F., Misset J. L., Reinberg A., Mathé G.: 5-day continuous venous infusion (CVI) of oxaliplatin (l-OHP) via ambulatory programmable pumps: constant vs circadian modulated infusion rate. Congrès International - La chimiothérapie en perfusion continue. Bordeaux, France, 21-22 Avril 1989.

Lévi F., Soussan A., Adam R., Caussanel J. P., Metzger G., Misset J. L.: Programmable - in - time pumps for chronotherapy of patients (pts) with colorectal cancer with 5-day circadian-modulated venous infusion of 5-fluorouracil (CVI - 5-FUra). Congrès International - La chimiothérapie en perfusion continue. Bordeaux, France, 21-22 Avril 1989.

Boughattas A. N., Lévi F., Lemaigre G., Roulon A., Mathé G.: Chronotoxicology of two platinum analogs following chronic dosing in mice. Proc. XIXth Int. Conf. of the Int. Soc. Chronobiology, Bethesda, USA. Chronobiologia, 1989, XVI (2): 114.

Touitou Y., Lévi F., Bailleul F., Bogdan A., Auzeby A., Touitou Y.: Circadian rhythmicity of CA 15.3, CEA and cortisol in breast cancer patients. Proc. XIXth Int. Conf. of the Int. Soc. Chronobiology, Bethesda, USA. Chronobiologia, 1989, XVI (2): 191.

Focan C., Driesschaert P., Lévi F., Nabholtz J. M., Pujol J. P., Thyss T.: Chronotherapy with etoposide and cisplatin for advanced lung carcinoma (LC). A progress report on a randomized trial of the "Cancer group of the Association de Chronobiologie Médicale". Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-0054.

Lévi F., Roulon A.: Circadian rhythm in antitumor effectiveness of 4'-tetrahydropyranyladriamycin (THP) in mice. Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-0140.

Boughattas A. N., Lévi F., Fournier C., Hecquet B., Bruguerolle B., Mechkouri M., Reinberg A., Mathé G.:Plasma chronopharmacokinetics following intravenous injection of oxaliplatin (l-OHP) and carboplatin (CBDCA) in mice. Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-0142.

Caussanel J. P., Lévi F., Misset J. L., Reinberg A., Mathé G.: Five-day continuous venous infusion (CVI) of oxaliplatin (l-OHP) via ambulatory programmable pumps: constant vs circadian modulated infusion rate. Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-0166.

Lévi F., Caussanel J. P., Adam R., Metzger G., Kunstlinger F., Lorphelin J. M., Bismuth H., Reinberg A., Misset J. L., Mathé G.: Circadian chronotherapy of colorectal cancer with 5-fluorouracil (5-FUra) with or without folinic acid (FOL) and oxaliplatinum (l-OHP). Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-0653.

Bizi E., Mechkouri M., Roulon A., Hallek M., Lévi F.: High-dose intensity treatment with mitoxanthrone (MIT): dependence upon circadian timing in mouse model. Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-0975.

Benavides M., Vennin P., Le Saunier F., Focan C., Krakowsky I., Unterreiner M., Thyss A., Misset J. L., Mathé G., Lévi F. for the Cancer Group: Chemotherapy of advanced ovarian cancer (ov. ca) with 4' - tetrahydropyranyladriamycin (THP) and cisplatin (CDDP). Proc. ECCO-5, 5th Eur. Conf. Clin. Oncol., 3-7 Sept. 1989, abst. P-1092.

Lévi F., Caussanel J. P., Adam R., Metzger G., Kunstlinger F., Lorphelin J. M., Bismuth H., Reinberg A., Misset J. L., Mathé G.: Automatized circadian chronotherapy of metastatic colorectal cancers with 5-fluorouracil (5-FUra), folinic acid (FOL) and oxaliplatinum (l-OHP). Symposium EORTC: Advances in gastrointestinal tract cancer research and treatment. Strasbourg, Nov. 15-17,1989.

1990

Lévi F., Canon C., Dipalma M., Florentin I., Misset J. L.: Chronopharmacology of biological response modifiers (BRM): from circadian pharmacodynamics to temporally - optimized drug delivery.The New York Academy of Sciences: Temporal control of drug delivery. New York, USA, February 26-28, 1990.

Boughattas A. N., Fournier C., Hecquet B., Lemaigre G., Roulon A., Reinberg A., Mathé G., Lévi F.: Circadian time-dependent tissue uptake of cisplatin (CDDP) and carboplatin (CBDCA) following repeated administrations: relationship with drug toxicities in mice. Fourth International Conference of Chronopharmacology and Chronotherapeutics. Biological rhythms and medications. Nice, France, March 12-15, 1990.

Lévi F., Misset J. L., Reinberg A.: Chronopharmacology and chronotherapy with particular reference to the evaluation of new anticancer agents. First ICR International Clinical Symposium. The role of clinical measurements in the evaluation of new drugs. Edinburgh, Ecosse, May 8-10, 1990.

Lévi F., Caussanel J. P., Adam R., Metzger G., Brienza S., Kunstlinger F., Lorphelin J. M., Descorps-Declère A., Bismuth H., Mathé G., Reinberg A., Misset J. L.: Ambulatory high dose circadian chemotherapy against metastatic colorectal cancer (ca.) with 5-fluorouracil (5-FUra), folinic acid (FOL) and oxaliplatin (l-OHP) via multichannel programmable pump. Proc. ASCO, Twenty-six Annual Meeting, Washington, USA, May 20-22 1990, 9: 117 (abst. 454).

Di Palma M., Misset J. L., Lévi F.: Very high daily doses of alpha-2-interferon at circadian modulated rate via a programmable pump to outpatients. Proc. AACR, Eighty-first Annual Meeting, Washington, USA, May 23-26 1990, 31: 283 (abst 1679)

Boughattas A. N., Lévi F., Fournier C., Hecquet B., Lemaigre G., Bruguerolle B., Roulon A., Reinberg A., Mathé G.: Pharmacokinetic mechanism of circadian rhythms in carboplatin toxicity in mice. Proc. AACR, Eighty-first Annual Meeting, Washington, USA, May 23-26 1990, 31: 385 (abst. 2282).

Boughattas A. N., Fournier C., Hecquet B., Lemaigre G., Roulon A., Reinberg A., Mathé G., Lévi F.: Circadian time-dependent tissue uptake of cisplatin (CDDP) and carboplatin (CBDCA) following repeated administrations: relationship with drug toxicities in mice. In: Ann. Rev. Chronopharmacol., 1990, 7 : 231-234.Fourth International Conference of Chronopharmacology and Chronotherapeutics. Biological rhythms and medications. Nice, France, March 12-15, 1990

Lévi F., Caussannel J. P., Boughattas A. N., Brienza S., Hecquet B., Neftel F., Gastiaburu J., Reinberg A., Mathé G., Misset J. L.: A chronopharmacologic strategy for the development of the new anticancer agent oxalatoplatinum (l-OHP): towards its conditioning into cheap, disposable and programmable-in-time micropumps. Ann. Rev. Chronopharmacol., 1990, 7: 235-236. Fourth International Conference of Chronopharmacology and Chronotherapeutics. Biological rhythms and medications. Nice, France, March 12-15, 1990.

Canon C., Lévi F., Mechkouri M., Debotte G., Reinberg A.: Circadian rhythms of surface epitope numbers (CD3 and CD4) from circulating lymphocytes of healthy male human subjects. Ann. Rev. Chronopharmacol., 1990, 7 : 209-210. Fourth International Conference of Chronopharmacology and Chronotherapeutics. Biological rhythms and medications. Nice, France, March 12-15, 1990.

Levi F., Metzger G., Misset J. L.: Automated circadian chronotherapy. UICC 15th Intern. Cancer Cong., Hambourg, Août 1990, J. Cancer Res. Clin. Oncol.,1990, 116 (suppl.):1072 (abst.# 16.20.02).

Roemeling R. V., Levi F., Diasio R., Hrushesky W.: Circadian time dependencies in toxicity of anticancer drugs. UICC 15th Intern. Cancer Cong., Hambourg, Août 1990, J. Cancer Res. Clin. Oncol., 1990, 116 (suppl.): 1072 (abst.# 16.20.02).

Lévi F., Misset J. L., Brienza S., Adam R., Le Couturier S., Gastiaburu J., Bourdoulous S., Metzger G., Bismuth H.: Circadian-rhythm modulated chemotherapy against metastatic colorectal cancer: results of an extended phase II chronotherapy trial with 5-fluorouracil (5-Fu), folinic acid (Fol) and oxalato-platinum (l-OHP) using an ambulatory multichannel programmable pump (IntelliJect R). XVth Congress of the European Society for Medical Oncology (ESMO), Copenhague, Décembre 1990, Ann. Oncol, 1 (suppl.): 43 (abst.# P6:4).

Lévi F., Boughattas N., Benavides M., Misset J. L.: Variabilité des résultats des essais: contrôle par une stratégie chronopharmacologique de développement du médicament. Société Française de Thérapeutique et de Pharmacologie Clinique. Thèmes d'actualités sur les bonnes pratiques dans les essais cliniques. Paris, 9 Mars 1990.

Lévi F. : Rythmes biologiques et chronothérapie anticancéreuse. Troisième Journée d'Oncologie Thoracique de l'Hôpital Saint-Joseph. Lyon, 13 Octobre 1990.

1991

Levi F., Misset J.L., Brienza S., Adam R., Gastiaburu J., Le Couturier S., Bourdoulous S., Metzger G., Bismuth H.: Circadian-rhythm modulated chemotherapy against metastatic colorectal cancer: results of an extended phase II chronotherapy trial with 5-fluorouracil (5Fu), folinic acid (Fol) and oxalato-platinum (l-OHP) using an ambulatory multichannel, programmable in time pump (IntelliJectR) Sixth international symposium on platinum and other metal coordination compounds in cancer chemotherapy, San Diego, 23-26 Janvier 1991,ISPCC 1991: 156 (abst.# P-122).

Boughattas A.N., Filipski Y., Lévi F.: Circadian time-dependent tissue levels of reduced glutathione (GSH) in mice: relationship with platinum toxicities. Sixth international symposium on platinum and other metal coordination compounds in cancer chemotherapy, San Diego, 23-26 Janvier 1991,ISPCC 1991: 292 (abst.# P-244).

Misset J.L., Kidani Y., Gastiaburu J., Jasmin C., Lévi F., Boughattas N., Lemaigre G., Brienza S., Goldschmidt E., Musset M., Mauvernay R.Y., Mathé G.: Oxalatoplatinum (l-OHP). Experimental and clinical studies. Sixth international symposium on platinum and other metal coordination compounds in cancer chemotherapy, San Diego, 23-26 Janvier 1991,ISPCC 1991: 47 (abst.# O-26).

Lévi F., Brienza S., Focan C., Perpoint B., Garufi C., Gatti G., La Torre Y., Gastiaburu J., Depres P., Misset J.L.: A phase II chronopharmacological trial of oxaliplatin (l-OHP) against metastatic colorectal cancer. Proc. AACR, Eighty-second annual meeting of the American Association for Cancer Research, May 15-18 1991, Houston Tx, USA, 1991, 32: 185 (abstr.# 1105).

Boughattas N., Lévi F.: Seasonal modulation of circadian rhythm in murine host tolerance for the new platinum analog, oxaliplatin (l-OHP). Proc. AACR, Eighty-second annual meeting of the American Association for Cancer Research, May 15-18 1991, Houston Tx, USA, 1991, 32: 412 (abstr.# 2449).

Lévi F., Misset J.L., Brienza S., Adam R., Kunstlinger F., Metzger G., Le Couturier S., Gastiaburu J., Bismuth H.: Circacdian-rhythm modulated venous chemotherapy against metastatic colorectal cancer: efficacy of pump delivered 5-fluorouracil (FU), folinic acid (FOL) and oxaliplatin (l-OHP). Proc. ASCO, 1991, 10: 155 (abstr. # 488).

Focan C., Bastens B., Driesschaert P., Lévi F., Longree L., Thyss A.: Chronotherapy with etoposide and cisplatin as first line treatment for advanced lung cancer. Proc. ASCO, 1991, 10: 264 (abstr. # 916).

Focan C., Longree L., Focan-Henrard D., Dallemagne B., Delforge M., Jacquet H., Malherbe R., Mazy V., Jehbes C., Weerts J., Lombard R., Lévi F.: A significant progress in the treatment of metastases from colorectal cancer: continuous arterial and venous chemotherapy using an ambulatory multichannel programmable in time pump. Acta Gastro-Enterologica Belgica, Proc. IIIrd Belgian Week of Gastroenterology, Knokke, Belgique, 7-10 Mars 1991, 54: C-71.

Vincent M., Levi F., Girodet B., Laennec E., Poirie P., Guibert B., Ardiet J.M., Boisson A., Van-Straaten L. : Circadian chemotherapy against non-small-cell lung cancer (NSCLC) with 5-Fluorouracil (5-Fu), Folinic Acid (Fol) and cisplatin (CDDP) via a multichannel programmable pump. Preliminary results. 3ème Congrès International sur la Chimiothérapie Néo-adjuvante, Paris, 6-9 Février 1991.

Lévi F. : Basi teoriche e sperimentali di cronochemoterapia dei tumori. Workshop : La chemoterapia cronomodulata mediante pompe infusionali nel trattamento delle neoplasie solide. Torino, Italie, 3 Mai 1991.

Lévi F. : Cancer chronotherapy to day : basic research and routine applications. 20th International Conference on Chronobiology, Tel Aviv, Israël, June 16-21 1991.

Boughattas N., Hecquet B., Lemaigre G., Filipski I., Fournier C., Lévi F. : Biochemical and pharmacokinetic mechanisms of the chronopharmacology of platinum (Pt) complexes. 20th International Conference on Chronobiology, Tel Aviv, Israël, June 16-21 1991.

Lévi F., Misset J.L., Brienza S., Adam R., Metzger G., Itzaki M., Caussanel J.P., Lecouturier S., Deprés-Brummer P., Bismuth H. : A chronopharmacologic phase II trial with 5-fluorouracil, folinic acid and oxaliplatinum using an ambulatory multichannel programmable pump : high antitumor effectiveness against metastatic colorectal cancer. 20th International Conference on Chronobiology, Tel Aviv, Israël, June 16-21 1991.

Andraud E., Bourin P., Mechkouri M., Lévi F. : Interleukin-2 (Il-2) toxicity varies by more than 50% in mice according to circadian dosing time. 20th International Conference on Chronobiology, Tel Aviv, Israël, June 16-21 1991.

Touitou Y., Bogdan A., Auzeby A., Levi F., Touitou C. : Circadian stage effect of metyrapone on mice adrenals in vitro. 20th International Conference on Chronobiology, Tel Aviv, Israël, June 16-21 1991.

Reinberg A., Touitou Y., Yayahi A., Nicolai A., Mechkouri M., Lévi F. : Effects of birth control pills (BCP) on certain physiological marker rhythms of healthy women. 20th International Conference on Chronobiology, Tel Aviv, Israël, June 16-21 1991.

Deprés-Brummer P., Lévi F., Di Palma M., Béliard A., Marion S., Jasmin C., Misset J.L. : A phase-I trial of 21-day continuous venous infusion alpha-interferon (IFN alpha 2 b) at circadian rhythm modulated rate in cancer. ECCO 6, 6th European Conference on Clinical Oncology and Cancer Nursing, Firenze, Italie, October 27-31 1991, abstr. 1216.

Benavides M., Misset J.L., Lévi F. : Long term survival in advanced ovarian cancer. ECCO 6, 6th European Conference on Clinical Oncology and Cancer Nursing, Firenze, Italie, October 27-31 1991, abstr. # 776.

Fournier C., Hecquet B., Boughattas N.A., Lévi F. : Pharmacokinetics and tissue distribution of 1,2 diammine (trans-1)cyclohexane oxaloplatinum (l-OHP) in mice. ECCO 6, 6th European Conference on Clinical Oncology and Cancer Nursing, Firenze, Italie, October 27-31 1991, abstr. # 1896.

Boughattas N., Lévi F. : Etude des mécanismes chronotoxicologiques des complexes de platine utilisés en chimiothérapie anticancéreuse. Colloque Toxicologie Recherche et Formation, Centre de Conférences Panthéon, Paris, 7 Mars 1991.

Adam R., Lévi F., Jeyaraj P., Brienza S., Le Couturier S., Deprès-Brummer P., Misset J.L., Bismuth H.: Chronothérapie des métastases hépatiques non resécables de cancer colo-rectal par pompe programmable. Journées de chirurgie hépato-biliaire, Paris, 30 Mai-1er Juin 1991.

Lévi F., Misset J.L., Brienza S., Adam R., Metzger G., Kunstlinger F., Lecouturier S., Deprés-Brummer P., Gastiaburu J., Bismuth H. : Chronothérapeutique des cancers colorectaux métastatiques : efficacité antitumorale d'une stratégie fondée sur les rythmes circadiens des tissus sains. 2ème Colloque "Pharmacologie, Médicament, Thérapeutique" " De la recherche à la découverte", Palais des Congrès du Futuroscope, Poitiers, 10 Juin 1991.

Adam R., Lévi F., Jeyaraj P., Brienza S., Lecouturier S., Misset J.L., Bismuth H. : Chronothérapie des métastases hépatiques non resécables de cancer colorectal par pompe programmable. XXIX Journées de Chirurgie Hépato-biliaire, Paris, 31-31 Mai-1er Juin 1991.

Lévi F. : La chrono-chimiothérapie. 9ème Journée de Cancérologie de Sarcelles, Sarcelles, 7 Décembre 1991.

1992

Levi F., Brienza S., Misset J.L., Adam R., Kunstlinger F., Metzger G., Deprés-Brummer P., Le Couturier S., Valori V., Maoudj E., Gastiaburu J., Jasmin C., Bismuth H. : Circumvention of clinical resistance of metastatic colorectal cancer to 5-fluorouracil (5-FU) with circadian rhythm modulated venous chemotherapy. Proc. Am. Soc. Clin. Oncol., 1992, 11 : 171. 28th Annual Meeting, San Diego, Ca, USA, May 17-19 1992.

Focan C., Lévi F., Le Couturier S., Adam R., Brienza S., Malherbe R., Longrée L., Focan-Henrard D., Lombard R., Misset J.L., Bismuth H. : Chronotherapy of hepatic metastases from colorectal cancer by local and general infusion. Proc. Am. Soc. Clin. Oncol., 1992, 11 : 182. 28th Annual Meeting, San Diego, Ca, USA, May 17-19 1992.

Metzger G., Comisso M., Massari C., Brienza S., Lévi F., Misset J.L. : Differences in time course of plasma levels of 5-fluorouracil (5-FU) during constant or chronomodulated infusion in cancer patients. Proc. Am. Ass. Cancer Res., 1992, 33 : 534. 83rd Annual Meeting, San Diego, Ca, USA, May 20-23, 1992.

Benavides M., Lévi F., Touitou Y., Reinberg A., Brienza S. : Circadian rhythms in cancer patients : the need to take them into account for chronotherapy trials. Proc. Am. Ass. Cancer Res., 1992, 33 : 223. 83rd Annual Meeting, San Diego, Ca, USA, May 20-23, 1992.

Lévi F., Bourin P., Pages N., Mechkouri M., Lemaigre G., Auzebi A., Touitou Y., Andraud E., Bohuon J., Misset J.L. : Dosing-time of IL-2 affects both lethal and central nervous system toxicities in mice. Proc. Am. Ass. Cancer Res., 1992, 33 : 329. 83rd Annual Meeting, San Diego, Ca, USA, May 20-23, 1992.

Boughattas N.A., Filipski J., Lemaigre G., Filipska E., Lévi F. : Buthionine sulfoximine (BSO) effects on circadian rhythms (cr) in toxicity of cisplatin (CDDP) and oxaliplatin (l-OHP) in mice. Proc. Am. Ass. Cancer Res., 1992, 33 : 540. 83rd Annual Meeting, San Diego, Ca, USA, May 20-23, 1992.

Adam R., Lévi F., Navarro F., Brienza S., Le Couturier S., Deprés-Brummer P., Misset J.L., Bismuth H. : Chronomodulated chemotherapy combined to subsequent liver resection in the treatment of unresectable liver metastases of colorectal origin. Eur. Surg. Res. Clin. Exp. Surg., 1992, 24-S2-92, abstr. # 188. 27th Congress Eur. Soc. Surg. Res. (ESSR), Zaragoza, Spain, May 20-23, 1992.

Adam R., Lévi F., Navarro F., Brienza S., Le Couturier S., Deprés-Brummer P., Misset J.L., Bismuth H. : Combined treatment of irresectable liver metastases of colorectal cancer by chemotherapy and subsequent hepatic resection. Brit. J. Surg., 1992, 79 (suppl. June) : S79. Eurosurgery' 92, 2nd Eur. Cong. Surg., Brussels, June 1992.

Lévi F., Brienza S., Deprés-Brummer P., Adam R., Berthault-Cvitkovic F., Kunstlinger F., Zidani R., Itzhaki M., Gastiaburu J., Bismuth H., Jasmin C., Misset J.L. : Chronotherapy of metastatic colorectal cancer with 5-fluorouracil (5-FU), folinic acid (Fol) and oxaliplatin (l-OHP), a new platinum complex : partial circumvention of clinical resistance to chemotherapy. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, IV-5.

Focan C., Lévi F., Le Couturier S., Adam R., Brienza S., Focan-Henrard D.,Kreutz F., Longree L., Mazy V., Lombard R., Misset J.L., Bismuth H. : Chronomodulated chemotherapy by local and general continuous infusion for hepatic metastases from colorectal cancer. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, IV-6.

Boughattas N., Filipski J., Lemaigre G., Bernard H., Fournier C., Filipska E., Lévi F. : Mechanistic approach of the chronopharmacology of platinum complexes. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, IV-7.

Bourin Ph., Lévi F., Pages N., Lemaigre G.: Circadian toxicity of interleukin-2 (IL-2) in mice. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, IV-9.

Challine D., Vassal G., Koscielny S., Deroussent A., Boland I., Hartmann O., Lévi F.: Chronopharmacology of high-dose busulfan in children. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, IV-11.

Benavides M., Lévi F., Reinberg A., Touitou Y. : Alteration of circadian rhythmicity in cancer patients : the role of prognostic factors. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, X-4.

Touitou Y., Lévi F., Bogdan A., Benavides M.,Focan C. : Rhythm desynchronization in cancer patients : a study on plasma cortisol, total proteins and tumor marker antigens. Proc. 5th Int. Conf. Chronopharm., Amelia Island, Fl., USA, July 12-16th 1992, X-5.

Deprés-Brummer P., Lévi F., Metzger G., Larue-Achagiotis C., Bogdan A., Touitou Y. : Does melatonin rhythm control circadian rhythm in body temperature of desynchronized rats ? Proc. Satellite Symposium of the IXth Intern. Cong. Endocrinol. : Melatonin and the pineal gland from basic science to clinical application, Paris, France, 6-9 Sept., 1992.

Lévi F., Brienza S., Metzger G., Deprés-Brummer P., Bertheault-Cvitkovic F., Zidani R., Adam R., Misset J.L. : Implication of chronobiology for 5-fluorouracil (5-FU) efficacy. Proc. Int. Symp. Novel Approaches to Selective Treatments of Human Solid Tumors : Laboratory and Clinical Correlation, Rosewell Park Cancer Institute, Buffalo, N.Y., USA, 9-12 Sept., 1992.

Lévi F. : Chronobiologic aspects of pharmacodynamic variability. 2nd Int. Workshop on Pharmacodynamics of Anticancer Agents, Eze, France, 16-20 Sept. 1992.

Lévi F. : Continuous infusion versus chronotherapy. Proc. Int. Symp. Infusion continua y cronoterapia en oncologia, Alicante, Spain, 2-3 Oct, 1992.

Bertheault-Cvitkovic F., Brienza S., Soussan A., Caussanel J.P., Misset J.L., Bismuth H., Lévi F. : Circadian-rhythm modulated 5-fluorouracil (5-FU) in advanced pancreatic cancer. Evidence for a dose intensity effect. Proc. XVIIth Cong. Eur. Soc. Med. Oncol., Lyon , France, 7-10 Nov., 1992. Ann. Oncol., 1992, 3 : 94.

Lévi F., Brienza S., Misset J.L., Adam R., Deprés-Brummer P., Bertheault-Cvitkovic F., Kunstlinger F., Zidani R., Itzhaki M., Gastiaburu J., Bismuth H., Jasmin C. : Intensified chronotherapy of metastatic colorectal cancer with 5-fluorouracil (5-FU), folinic acid (FOL) and oxaliplatin (l-OHP), a new complex : partial circumvention of clinical resistance to chemotherapy. Proc. XVIIth Cong. Eur. Soc. Med. Oncol., Lyon , France, 7-10 Nov., 1992. Ann. Oncol., 1992, 3 : 59.

Vincent M., Lévi F., Girodet B., Laennec E., Poirie P., Guibert B., Ardiet J.M., Boisson A., Van-Straaten L. : Circadian chemotherapy against IIIB-IV non-small-cell lung cancer (NSCLC) with 5-fluorouracil (5-FU) and cisplatinum (CDDP) via a multichannel programmable pump. Proc. XVIIth Cong. Eur. Soc. Med. Oncol., Lyon , France, 7-10 Nov., 1992. Ann. Oncol., 1992, 3 : 129.

Adam R., Lévi F., Navarro F., Brienza S., Lecouturier S., Deprés-Brummer P., Misset J.L., Bismuth H. : Traitement combiné des métastases hépatiques non resécables de cancer colo-rectal par chronochimiothérapie systémique et hépatectomie secondaire. Journées Francophones de Pathologie Digestive, Paris, 28 Mars-1er Avril 1992.

Lévi F. : Chronothérapeutique des cancers. Entretiens de Bichat, Paris, 19-26 Septembre 1992.

1993

Lévi F. : Who are the patients with metastatic colorectal cancer who may be cured by an aggressive chronotherapy-surgery program ? Int. Workshop on Perioperative Treatment of Gastrointestinal Tumors, Zürs, Austria, January 27-30, 1993.

Lévi F. : Biological rhythms : relevance for toxicokinetics. Drug Information Association International Workshop : Toxicokinetics - The Way Forward, Nice, 24-26 Feb. 1993.

Lévi F. : Chronochemotherapy of cancer. Proc. 27th Annual Scientific Meeting of the European Society for Clinical Investigation, Heidelberg, Federal Republic of Germany, April 14-17th 1993. Eur. J. Clin. Invest., 1993, 23 : A 51 (abstr. # 292).

Deprés-Brummer P., Lévi F., Metzger G., Hecquet B., Misset J.L. : Non-invasive monitoring of circadian rhythms in cancer patients by wrist actigraphy. Proc. 27th Annual Scientific Meeting of the European Society for Clinical Investigation, Heidelberg, Federal Republic of Germany, April 14-17th 1993. Eur. J. Clin. Invest., 1993, 23 : A 51 (abstr. # 296).

Lévi F. : Chronotherapy. Biological basis and clinical application. "New approaches to Anticancer Chemotherapy : from basic concepts to therapeutic strategy in onco-haematology" satellite syposium of ESH-Eurocancer, Château de Maffliers, 23-25 Avril, 1993.

Boughattas N.A., Li X.M., Filipski J., Metzger G., Filipski E., Mechkouri M., Lévi F. : Chronopharmacologic effects of a biochemical modulator of cisplatin (CDDP) and oxaliplatin (L-OHP) toxicities in mice. 84th Annual Meeting of Am. Ass. Cancer Res., Orlando, USA, May 19-22 1993. Proc. Am. Ass. Cancer Res., 1993, 34 : 286 (abstr. # 1699).

Brienza S., Fandi A., Hugret F., Itzhaki M., Lecouturier S., Gastiaburu J., Deprés-Brummer P., Misset J.L., Lévi F. : Neurotoxicity of long term oxaliplatin (L-OHP) therapy. 84th Annual Meeting of Am. Ass. Cancer Res., Orlando, USA, May 19-22 1993. Proc. Am. Ass. Cancer Res., 1993, 34 : 406 (abstr. # 2421).

Perpoint B., Le Bousse-Kerdilès C., Clay D., Smadja-Joffe F., Deprés-Brummer P., Laporte-Simitsidis S., Jasmin C., Lévi F. : In vitro chronopharmacology of recombinant mouse IL-3, mouse GM-CSF and human G-CSF on murine myeloid progenitor cells. 84th Annual Meeting of Am. Ass. Cancer Res., Orlando, USA, May 19-22 1993. Proc. Am. Ass. Cancer Res., 1993, 34 : 468 (abstr. # 2793).

Martineau N., Lévi F., Deloche C., Chollet Ph., Madelmont J.C. : Chronotoxicity of cystemustine (cyst), a new nitrosourea, in mice : relevance for chronomodulated drug delivery. 84th Annual Meeting of Am. Ass. Cancer Res., Orlando, USA, May 19-22 1993. Proc. Am. Ass. Cancer Res., 1993, 34 : 271 (abstr. # 1614).

Lévi F., Zidani R., Vannetzel J.M., Perpoint B., Focan C., Itzhaki M., Faggiuolo R., Garufi C., Chollet Ph., Iacobelli S., Misset J.L. for the Inter. Org. for Cancer Chronotherapy (IOCC) : Combined infusion of 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) against metastatic colorectal cancer. Pitfalls of drug admixture and large reduction of toxicity through circadian rhythm-modulated drug delivery. 29th Annual Meeting Am. Soc. Clin. Oncol., Orlando, USA, May 16-18 1993. Proc. Am. Soc. Clin. Oncol., 1993, 12 : 213 (abstr. # 644).

Brienza S., Lévi F., Valori V.M., Bertheault-Cvitkovic F., Deprés-Brummer P., Lecouturier S., Kunstlinger F., Adam R., Misset J.L., Bismuth H. : Intensified (every 2 weeks) chronotherapy with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) in previously treated patients with metastatic colorectal cancer. 29th Annual Meeting Am. Soc. Clin. Oncol., Orlando, USA, May 16-18 1993. Proc. Am. Soc. Clin. Oncol., 1993, 12 : 197 (abstr. # 577).

Lévi F., Zidani R., Vannetzel J.M., Perpoint B., Focan C., Itzhaki M., Faggiuolo R., Garufi C., Chollet P., Iacobelli S., Misset J.L. : Combined intravenous infusion of 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) against metastatic colorectal cancer. Results of a first european randomized multicenter trial of flat vs chronomodulated delivery. Proc. XXI Conference Intern. Soc. for Chronobiol., Quebec City, Canada, July 11-15 1993 (abstr. # VI-6).

Metzger G., Li X.M., Filipski E., Boughattas N., Filipski J., Lévi F. : Amplification of circadian rhythm in cisplatin toxicity through biochemical modulation with buthionine sulfoximine in mice. Proc. XXI Conference Intern. Soc. for Chronobiol., Quebec City, Canada, July 11-15, 1993 (abstr. # III-5).

Touitou Y., Lévi F., Bogdan A., Benavides M. : Circadian alterations of blood variables in patients with metastatic breast cancer and their relationship with prognostic factors. Proc. XXI Conference Intern. Soc. for Chronobiol., Quebec City, Canada, July 11-15, 1993 (abstr. # VII-3).

Lévi F., Zidani R., Metzger G., Misset J.L. : Injectable chronotherapeutic delivery in cancer therapy. Proc. Eur. Soc. Chronobiol., Bath, UK, Sept. 16-19, 1993.

Deprés-Brummer P., Metzger G., Larue-Achagiotis C., Touitou Y., Lévi F. : Prolonged exposure of rats to constant light : an animal model of environmentally induced functional suppression of the circadian system. Proc. Eur. Soc. Chronobiol., Bath, UK, Sept. 16-19, 1993.

Lévi F., Deprés-Brummer P., Metzger G., Benavides M., Bourin P., Zidani R., Touitou Y., Misset J.L. : Normal and abnormal circadian rhythms. Proc. Relationships in relation to in vivo monitoring, Workshop on Chronobiology, Porto, (Portugal), 14-15 October, 1993.

Lévi F. : Cancer chronotherapy. Symposium : From Chronobiology to Chronotherapeutics. Bruxelles, Belgique, 23 Novembre 1993.

Lévi F. : La chronothérapie : données nouvelles. MEDEC 93, Paris, 31 Mars-1er Avril 1993.

Deprés-Brummer P., Lévi F., Brienza S., Valori V.M., Bertheault-Cvitkovic F., Lecouturier S., Kunstlinger F., Adam R., Misset J.L., Bismuth H. : Chronothérapie intensifiée par 5-fluorouracile (5-FU), acide folinique (FOL) et oxaliplatine (L-OHP) chez des patients atteints de métastases de cancers colorectaux et antérieurement traités. 13ème Forum de Cancérologie, Paris, 14-16 Juin, 1993.

Metzger G., Li X.M., Filipski E., Boughattas N., Filipski J., Lévi F. : Amplification du rythme circadien de la toxicité du cisplatine chez la souris par un modulateur biochimique, la buthionine sulfoximine (BSO) : un nouveau concept chronothérapeutique. IVème colloque CNRS "De la Recherche à la Découverte" : Thérapeutique et Médicaments : concepts et moyens. Strasbourg, 1-2 Décembre 1993.

Deprés-Brummer P., Metzger G., Lévi F. : Suppression fonctionnelle des rythmes circadiens chez le rat : un modèle d'étude chronopharmacologique. IVème colloque CNRS "De la Recherche à la Découverte" : Thérapeutique et Médicaments : concepts et moyens. Strasbourg, 1-2 Décembre 1993.

Lévi F. : La chronochimiothérapie en cancérologie digestive. 4ème Journée d'Oncologie Thoracique et Chimiothérapie. Lyon, 4 Décembre 1993.

Lévi F., Misset J.L., Jasmin J.L., Bismuth H. : Injecteurs programmables pour chronothérapie : validation du principe de chronomodulation circadienne de la chimiothérapie anticancéreuse. 2ème Colloque de Recherche Clinique AP-HP : stratégie des thérapeutiques innovantes. Paris, 6-7 Décembre 1993.

1994

Deprés-Brummer P., Metzger G., Lévi F. : Light induced functional suppression of rat circadian rhythms. Gordon Research Conferences : Pineal Cell Biology Conference. Oxnard, California, USA, January 23-28 1994.

Martineau N., Lévi F., Deloche C., Chollet P., Madelmont J.C. : Chronotoxicity of cystemustine (CYST), a new nitrosourea, in mice : relevance for chronomodulated drug delivery. Proc. 8th NCI-EORTC Symposium on New Drugs in Cancer Therapy. Amsterdam, Netherlands, March 15-18, 1994 (abst. # 0428).

Deprés-Brummer P., Bourin P., Filipski E., Metzger G., Comisso M., Li X.M., Lévi F. : A rat model for circadian rhythm alterations in cancer patients. Proc. 85th Annual Meeting Am. Ass. Cancer Res., San Francisco, CA, USA, April 10-13, 1994, 35 (abst. # 523).

Lévi F., Zidani R., Di Palma M., Faggiuolo R., Garufi C., Chollet P., Focan C., Iacobelli S., Perpoint B., Le Rol A., Itzhaki M., Vannetzel J.M., Misset J.L. for the Intern. Org. for Cancer Chronotherapy (IOCC) : Circadian rhythm-modulated (CRM) vs flat delivery of combined oxaliplatin (L-OHP), 5-fluorouracil (5-FU) and folinic acid (FA), against metastatic colorectal cancer. A multicenter randomized Phase III trial. Proc. 85th Annual Meeting Am. Ass. Cancer Res., San Francisco, CA, USA, April 10-13, 1994, 35 (abst. # 1376).

Lévi F., Zidani R., Di Palma M., Faggiuolo R., Garufi C., Chollet P., Focan C., Iacobelli S., Perpoint B., Le Rol A., Itzhaki M., Vannetzel J.M., Misset J.L. for the Intern. Org. for Cancer Chronotherapy (IOCC) : Improved therapeutic index through ambulatory circadian rhythmic delivery (CRD) of high dose 3-drug chemotherapy in a randomized Phase III multicenter trial. Proc. 30th Annual Meeting Am. Soc. Clin. Oncol., Dallas, Tx, USA, May 14-17, 1994, 13 (abstr. # 574).

Deprés-Brummer P., Lévi F., Bertheault-Cvitkovic F., Brienza S., Jasmin C., Misset J.L. : A Phase I trial of circadian-rhythm modulated (CRM) chemotherapy of metastatic breast cancer (MBC) with mitoxantrone (MIT), 5-fluorouracil (5-FU) and folinic acid (FA). Proc. 30th Annual Meeting Am. Soc. Clin. Oncol., Dallas, Tx, USA, May 14-17, 1994, 13 (abstr. # 207).

Bertheault-Cvitkovic F., Jami A., Itzhaki M., Brienza S., Deprés-Brummer P., Adam R., Metzger G., Caillet H., Kunstlinger F., Maoudj E., Bismuth H., Misset J.L., Lévi F. : Dose intensification (DI) of circadian-rhythm modulated 5-fluorouracil (5-FU) combined with oxaliplatin (L-OHP) and folinic acid (FA) against metastatic colorectal cancer. A feasibility study. Proc. 30th Annual Meeting Am. Soc. Clin. Oncol., Dallas, Tx, USA, May 14-17, 1994, 13 (abstr. # 653).

Giacchetti S., Adam R., Alafaci E., Itzhaki M., Zidani R., Brienza S., Bertheault-Cvitkovic F., Deprés-Brummer P;, Bismuth H., Jasmin C., Misset J.L., Lévi F. : Surgery of liver and pulmonary metastases after chronomodulated chemotherapy (CMCT) in metastatic colorectal carcinoma (MCC). Proc. 30th Annual Meeting Am. Soc. Clin. Oncol., Dallas, Tx, USA, May 14-17, 1994, 13 (abstr. # 652).

Lévi F. : Immunity and chronobiology. Proc. 6th Int. Conf. on Immunopharmacol., Annecy, France, 27-28 May 1994.

Levi F., Metzger G., Deprés-Brummer P., Giacchetti S., Brienza S., Misset J.L. : Programmable-in-time drug delivery devices (pumps) for chronotherapy. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # II-7).

Metzger G., Li X.M., Filipski E., Mechkouri M., Boughattas N., Filipski J., Lévi F. : Modulation of glutathione circadian rhythm with buthionine sulfoximine. Effects on platinum complexes toxicity in mice. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIa-8).

Tampellini M., Filipski E., Lévi F. : Circadian rhythm of vinorelbine tolerability in mice : possible relationship with anticancer activity. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIa-9).

Li X.M., Ramirez L., Grognet J.M., Soulard C., Filipski E., Mormont C., Thomas F., Lévi F. : Seraspenide-induced amplification of hematologic circadian rhythms in mice : preliminary results of dose-response relationship. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIa-10).

Mille D., Bourin P., Lévi F., Choisy P., Perpoint B. : In vitro circadian rhythm in cloning efficiency of murine bone marrow. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIa-11).

Lévi F., Zidani R., Dipalma M., Faggiuolo R., Garufi C., Chollet P., Focan C., Iacobelli S;, Perpoint B., Le Rol.A., Itzhaki M., Vannetzel J.M., Kunstlinger F., Adam R., Misset J.L. : A randomized Phase III clinical trial of 3-drug chronotherapy in patients with metastatic colorectal cancer : improved therapeutic index through ambulatory circadian rhythmic delivery (CRD). Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIb-2).

Chollet P., Curé H., Garufi C., Focan C., Pezet D., Giunta S., Terzoli E., Ravoux M.A., Martineau N., Chipponi J., Lévi F. : Phase II trial with chronomodulated 5-fluorouracil (5-FU) and folinic acid (FA) in metastatic colorectal cancer. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIb-4).

Focan C., Kreutz F., Focan-Henrard D., Brienza S., Adam R., Dallemagne B., Weerts J., Bismuth H., Misset J.L., Lévi F. : Chronotherapy of hepatic metastases from colorectal cancer with continuous delivery of 5-fluorouracil (5-FU) by venous and 5-fluorodesoxyfuridine (FUDR) by arterial route : a randomized evaluation comparing combined flat versus chrono-modulated infusion. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIb-5).

Vincent M., Lévi F., Girodet B., Laennec E., Poirie P., Guibert B., Ardiet J.M., Renaudier P., Van-Straaten L. : Circadian chemotherapy against stage IIIB-4 non-small-cell lung cancer (NSCLC) with 5-fluorouracil (5-FU, folinic acid (FOL) and cisplatinum (CDDP) via a multichannel programmable pump. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIb-7).

Deprés-Brummer P., Lévi F., Bertheault-Cvitkovic F., Brienza S., Vannetzel J.M., Jasmin C., Misset J.L. : Circadian-rhythm modulated (CRM) chemotherapy in previously treated patients with metastatic breast cancer with mitoxantrone (MIT), 5-fluorouracil (5-FU) and folinic acid (FA) : preliminary results of a phase I-II trial. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIb-8).

Mormont, Hecquet B., Benavides M., Bogdan A., Metzger G., Touitou Y., Lévi F. : Selection and validation of a simple, non-invasive test of circadian rhythm alterations in cancer patients : consequences for chronotherapy. Proc. 6th Int. Conf. Chronopharmacol. Chronother. Biological Rhythms and Medications, Amelia Island, Fl., USA, July 5-9, 1994 (abstr. # VIIIb-9).

Lévi F. : Chronotherapy in advanced colorectal cancer. II Simposio Internacional de tratamiento de tumores digestivos. Quimioterapia en Ca. Colorectal Avanzado, Cordoue, Espagne, 19-20 Octobre 1994.

Lévi F., Zidani R., Faggiuolo R., Giacchetti S., Perpoint B., Chollet P., Lerol A., Farabos C., Kanoui A., Vannetzel J.M., Focan C., Garufi C., Itzhaki M., Alafaci E., Gruia G., Bertheault-Cvitkovic F., Misset J.L. : A european multicenter Phase II trial of intensified 4-day every-two-weeks chronotherapy with oxaliplatin (L-OHP), 5-fluorouracil (5-FU) and folinic acid (FA) in 102 patients (pts) with metastatic colorectal cancer. Proc. 19th ESMO Congress, Lisbon, Portugal, November 18-22, Annals of Oncol., 5 (Suppl. 8), (abstr. # 0215), 1994.

Giacchetti S., Adam R., Itzhaki M., Alafaci E., Zidani R., Brienza S., Bertheault-Cvitkovic F., Deprés-Brummer P., Bismuth H., Jasmin C., Cvitkovic E., Misset J.L., Lévi F. : Surgery of colorectal cancer metastases after chronomodulated chemotherapy. Proc. 19th ESMO Congress, Lisbon, Portugal, November 18-22, Annals of Oncol., 5 (Suppl. 8), (abstr. # 0215), 1994.

Focan C., Kreutz F., Focan -Henrard D., Brienza S., Adam R., Dallemagne B., Weerts J., Bismuth H., Misset J.L., Lévi F. : Treatment of hepatic metastases from colorectal cancer with continuous delivery of venous 5-fluorouracil (5-FU) ans arterial 5-fluorodesoxyuridine (FUDR). A randomized evaluation comparing combined flat versus chronomodulated infusion. Proc. 19th ESMO Congress, Lisbon, Portugal, November 18-22, Annals of Oncol., 5 (Suppl. 8), (abstr. # 0215), 1994.

Focan C., Denis B., Kreutz F., Focan-Henrard D., Lévi F. : Ambulatory chronotherapy with 5-fluorouracil (5-FU), folinic acid (F) and carboplatin for advanced non small cell lung cancer (NSCLC). Proc. 19th ESMO Congress, Lisbon, Portugal, November 18-22 1994, Annals Oncol., 1994, 5 (suppl. 8) : P760 (abstr.)

Lévi F. Administration ambulatoire de médicaments anti-cancéreux. Eurocancer 94, Paris, France, 26-29 Avril 1994.

Lévi F. Chronothérapie des métastases hépatiques synchrones de cancer colorectal. Association Franç. de Chirurgie, Paris, 3 Octobre 1994.

Lévi F. Chronochimiothérapie : bases théoriques et résultats cliniques. 24 heures de cancérologie, Le Mans, France, 15 Octobre 1994.

Lévi F. Les nouveaux modes d’administration des anticancéreux. 45èmes Journées Pharmaceutiques Internationales de Paris, 4-7 Novembre 1994.

Lévi F. Chronochimiothérapie dans l’augmentation de la dose-intensité. Soc. Franç. du Cancer, Colloque Intensité de dose en chimiothérapie anticancéreuse, Paris, France, 19 Décembre 1994.

1995

Lévi F., Giacchetti S., Adam R., Zidani R., Metzger G., J.L. Misset for the International Organisation for Cancer Chronotherapy : Chronomodulation of chemotherapy against metastatic colorectal cancer. 15th Anniversary International Congress « Colorectal Cancer : from gene to cure », The Academic Medical Centre, Amsterdam, February 9-11 1995, Eur. J. Cancer, 1995, 31A (7/8) : 1264-1270.

Mormont M.C., Metzger G., Zidani R., Gruia G., Misset J.L., Lévi F. : Non invasive estimation of cancer patient’s circadian system with wrist actigraphy. Proc. 86th Annual Meeting of the Am. Ass. Cancer Res., Toronto, Ontario, Canada, March 18-22 1995, vol. 36 : abstr. 1263.

Chabot G.G., Li X.M., Vergus M.A., Metzger G., Lévi F. : Circadian variation of the principal drug-metabolizing enzyme systems in mouse livers. Proc. 86th Annual Meeting of the Am. Ass. Cancer Res., Toronto, Ontario, Canada, March 18-22 1995, vol. 36 : abstr. 1872.

Tampellini M., Filipski E., Vrignaud P., Bissery M.C., Lévi F. : Circadian dosing time dependency of docetaxel toxicity in mice : implication for antitumor efficacy. Proc. 86th Annual Meeting of the Am. Ass. Cancer Res., Toronto, Ontario, Canada, March 18-22 1995, vol. 36 : abstr. 2713.

Lévi F., Zidani R., Giacchetti S., Metzger G., Li X.M., Misset J.L. : Chronomodulation of combined platinum complexes and 5-fluorouracil delivery. Proc. 7th International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy (ISPCC’95), Amsterdam, The Netherlands, March 1-4, 1995.

Focan C., Kreutz F., Focan-Henrard D., Adam R., Dallemagne B., Jehaes C., Markiewicz S., Weerts J., Delforge M., Lévi F. : Treatment of hepatic metastases form colorectal cancer with continuous delivery of venous 5-fluorouracil (5-FU) and arterial 5-fluorodesoxyuridine (FUDR). A randomized evaluation comparing combined flat versus chrono-modulated infusion. Belgian Week of Gastroenterology, Knokke, Belgium, March 16-18, 1995.

Lévi F., Benavides M., Deprés-Brummer P., Mormont M.C., Touitou Y. : Normal or abnormal circadian rhythms in cancer patients : diagnostic and therapeutic implications. Gordon Research Conferences, Gordon Conference on Chronobiology 1995, Il Ciocco, Barga, Italy, April 30-May 5, 1995.

Deprés-Brummer P., Bourin P., Filipski E., Melotée D., Metzger G., Lévi F. : Persistent rhythms in rat lymphocyte subsets despite light-induced suppression of temperature and activity rhythms. Gordon Research Conferences, Gordon Conference on Chronobiology 1995, Il Ciocco, Barga, Italy, April 30-May 5, 1995

Garufi C., Brienza S., Bensmaïne M.A., Misset J.L., Aschelter A., Pace R., Bertheault-Cvitkovic F., Terzoli E., Lévi F. : Addition of oxaliplatin (L-OHP) to chronomodulated (CM) 5-fluorouracil (5-FU) and folinic acid (FA) for reversal of acquired chemoresistance in patients with advanced colorectal cancer (ACC). Proc. 31st Annual Meeting of the Am. Soc. Clin. Oncol., Los Angeles, CA, U.S.A., May 20-23 1995, vol. 14 : abstr. 446

Giacchetti S., Gruia G., Itzhaki M., Adam R., Brienza S., Deprés-Brummer P., Bertheault-Cvitkovic F., Bismuth H., Cvitkovic E., Misset J.L., Lévi F. : Surgery after chronomodulated chemotherapy with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) (chrono) allows long term survival of patients (pts) with unresectable colorectal liver metastases. Proc. 31st Annual Meeting of the Am. Soc. Clin. Oncol., Los Angeles, CA, U.S.A., May 20-23 1995, vol. 14 : abstr. 492.

Lévi F., Zidani R., Vannetzel J.M., Faggiuolo R., Garufi C., Chollet P., Focan C., Perpoint B., Iacobelli S., Le Rol A., Deprés-Brummer P., Itzhaki M., Misset J.L. : Chronomodulated versus flat infusion of 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) against metastatic colorectal cancer (MCC) in 2 consecutive european randomized multicenter trials (T). Proc. 31st Annual Meeting of the Am. Soc. Clin. Oncol., Los Angeles, CA, U.S.A., May 20-23 1995, vol. 14 :  abstr. 493.

Lévi F., Dogliotti L., Perpoint B., Zidani R., Giacchetti S., Chollet P., Le Rol A., Llory J.F., Focan C., Gruia G., Farabos C., Kunstlinger F., Itzhaki M., Adam R., Faggiuolo R., Vannetzel J.M., Jasmin C., Bismuth H., Misset J.L. : Ambulatory intensified 4-day (d) every 2 weeks chronotherapy with oxaliplatin (L-OHP), 5-fluorouracil (5-FU) and folinic acid (FA) in patients (pts) with metastatic colorectal  cancer (MCC). Proc. 31st Annual Meeting of the Am. Soc. Clin. Oncol., Los Angeles, CA, U.S.A., May 20-23 1995, vol. 14 : abstr. 568.

Adam R., Bismuth H., Farabos C., Lévi F. : Resection of non resectable hepatic metastases of colorectal cancer after initial chemotherapy. Proc. XXX Cong. Eur. Soc. Surgical Res. (ESSR), May 10-13 , 1995, Amsterdam, The Netherlands.

Tampellini M., Filipski E., Lévi F. : Circadian variation of vinorelbine toxicity in mice. Proc. Eurocancer 95, Paris, France, 30 Mai - 2 Juin, 1995, poster II.4.

Lévi F. : Cancer-related chronobiology. Proc. 19th Intern. Cong. of Chemother. (19 ICC), Montréal, Québec, Canada, July 16-21, 1995.

Lévi F. : Cancer chronotherapy : from preclinical to clinical Phase III validation. Proc. World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 411 (abstr. 140).

Metzger G., Li X.M., Lévi F. : Circadian rhythm period of platinum toxicity changed by a biochemical modulator. Proc. World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 419 (abstr. 158).

Deprés-Brummer P., Bourin P., Filipski E., Melotée D., Metzger G., Lévi F. : Rat lymphocyte subset rhythms under continuous light or darkness. World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 382 (abstr. 67).

Deprés-Brummer P., Metzger G., Touitou Y., Lévi F. : Effect of daily melatonin injections on temperature and activity rhythms in constant light. Proc.World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 383 (abstr. 68).

Mormont M.C., De Prins J., Lévi F. : Assessment of circadian activity rhythms by wrist actigraphy in patients with colorectal cancer. Proc.World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 423 (abstr. 167).

Mormont M.C., Lévi F. : Circadian system alterations during cancer processes. Proc. World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 423 (abstr. 168).

Langouët A.M., Metzger G., Comisso M., Renée N., Milano G., Mormont M.C., Gruia G., Giacchetti S., Lévi F. : Plasma concentration of 5-fluorouracil and mononuclear cell dihydropyrimidine dehydrogenase activity in patients treated with different chronomodulated schedules. Proc. World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 409 (abstr. 135).

Tampellini M., Filipski E., Vrignaud P., Bissery M.C., Lévi F. : Circadian variations of docetaxel tolerability in mice : relationship with its antitumor efficacy. Proc.World Conference on Chronobiology and Chronotherapeutics, Ferrara, Italy, September 6-10 1995, Biol. Rhythm Res., 1995, 26 (4) : 447 (abstr. 227).

Lévi F. : Chronomodulation of chemotherapy against metastatic colorectal cancer. Infusional Chemotherapy Cong., Paris, France, September 14-15, 1995.

Bismuth H., Adam R., Farabos C.H., Lévi F. : Resection of unresectable hepatic metastases from colorectal cancer with neoadjuvant chronotherapy. Proc. ECCO8, Paris, France, 29 Oct. - 2 Nov. 1995, Eur. J. Cancer, 1995, 31A (suppl. 5) : S209, abstr. 1004.

Lévi F. : Chrono-chemiothérapie des métastases hépatiques. Journées Médico-chirurgicales d’Hépatologie et de Gastroentérologie, Genève, Suisse, 16-17 Novembre 1995.

Maoudj E., Lebugle M., Reggane M., Salvat D., Metzger G., Misset J.L., Lévi F. : Place de l’infirmière dans le transfert du principe de chronothérapie en oncologie. Colloque INSERM, La Recherche Infirmière en France, Paris, 10-11 Mars 1995.

Lévi F. : Chimiothérapie chronomodulée associant oxaliplatine, 5-fluorouracile (5-FU) et acide folinique (AF). Symposium Cancers du Côlon et du Rectum, Traitements Actuels, Villejuif, 22 Juin 1995.

Lévi F. : Les métastases hépatiques des cancers colorectaux - Place de la chimiothérapie chronomodulée. Congrès de la Société Française de Cancérologie Privée, Strasbourg, France, 16 Septembre 1995.

Lévi F. : Bases fondamentales et pharmacologiques de la chronomodulation. VIèmes Entretiens Servier en Cancérologie, Paris, France, 20 Septembre 1995.

Zidani R., Faggiuolo R., Giacchetti S., Perpoint B., Chollet P., Le Rol A., Farabos C., Kanoui A., Vannetzel J.M., Focan C., Itzhaki M., Gruia G., Bertheault-Cvitkovic F., Kunstlinger F., Misset J.L., Lévi F. : Essai multicentrique européen de Phase II d’intensification de dose avec Oxaliplatine (L-OHP), 5-fluorouracile (5-FU) et Acide Folinique (AF) - 4 jours toutes les 2 semaines, chez 90 patients atteints de cancer colorectal métastasé. XVème Forum de Cancérologie, Paris, 12-14 Juin 1995.

1996

Deprés-Brummer P., Metzger G., Claustrat B., Touitou Y., Lévi F. : Melatonin in rats with a functional suppression of the circadian system. Gordon Research Conferences, Ventura, CA, U.S.A., February 3-9 1996.

Lévi F. : Oxaliplatin, 5-fluorouracil and folinic acid (FFL) : activity of five-day chronomodulated infusion against metastatic colrectal cancer. Symposium Oxaliplatin - S.O.M.P.S., Paris, France, 7 Février 1996.

Garufi C., Brienza S., Bensmaïne M.A., Misset J.L., Ascheiter A., Paca R., Bertheault-Cvitkovic F., Terzoli E., Lévi F. : Addition of oxaliplatin (L-OHP) to chronomodulated (CM) 5-fluorouracil (5-FU) and folinic acid (FA) for reversal of acquired chemoresistance in patients with advanced colorectal cancer (ACC). S.O.M.P.S., Paris, France, 7 Février 1996.

Langouët A.M., Metzger G., Comisso M., Renée N., Milano G., Mormont C., Lévi F.: Plasma drug concentration control through time-programmed administration. Proc. 87th meeting Am. Ass. Cancer Res., Washington D.C., U.S.A., March 20-24 1996, vol. 37, abstr. 1253.

Lévi F. : Potential role of melatonin in cancer chronotherapy. Melatonin Receptors : new targets for a novel therapeutic agent ?, Barcelona, Spain, April 1-2, 1996.

Lévi F. : Cancer chronotherapy. Proc. E.S.C.P. 3rd Eur. Conf. Cancer Care & Pharmacoepidemiol., Linz, Austria, April 24-26 1996.

Gruia G., Giacchetti S., Deprés P., Jami A., Zidani R., Bleuzen P., Misset J.L., Lévi F. : Role of time of peak delivery of chronomodulated 5-fluorouracil (5-FU), l-leucovirin (LV) and oxaliplatin (L-OHP) in patients with metastatic colorectal cancer. Proc. 32nd meeting Am. Soc. Clin. Oncol., Philadelphia, PA, U.S.A., May 18-21 1996, vol. 15 : abstr. 372.

Deprés-Brummer P., Bleuzen P., Di Palma M., Ecstein E., Kreutz F., Kunstlinger F., Misset J.L., Jasmin C., Focan C., Lévi F. : A Phase II study of ambulatory chronomodulated high dose interferon (IFNa2a) against metastatic renal cancer (MRC). Proc. 32nd meeting Am. Soc. Clin. Oncol., Philadelphia, PA, U.S.A., May 18-21 1996, vol. 15 : abstr. 628.

Mormont M.C., Lévi F., Deprés-Brummer P., Giacchetti S., Gruia G., Bleuzen P., Jasmin C., Misset J.L. : Rest-activity circadian rhythm : an objective measure for performance status (PS) and a strong indicator for quality of life. Proc. 32nd meeting Am. Soc. Clin. Oncol., Philadelphia, PA, U.S.A., May 18-21 1996, vol. 15 : abstr. 1633.

Pugliese P., Garufi C., Nisi E., Caruso A., Pace R., Nistico C., Aschelter A.M., Giunta S., Lévi F., Terzoli E.: Advanced colorectal cancer : evaluation of quality of life (QL) with the E.O.R.T.C. QLQ C30 during infusional chronotherapy. Proc. 32nd meeting Am. Soc. Clin. Oncol., Philadelphia, PA, U.S.A., May 18-21 1996, vol. 15 : abstr. 1647.

Lévi F. : Synchronization of physiological rhythms in relation to cancer therapeutics. Circadian Light Reception and Regulation, I.N.S.E.R.M., Lyon, France, May 22-25 1996.

Adam R., Bismuth H., Farabos Ch., Lévi F., Waechter F. : Unresectable hepatic metastases from colorectal cancer : results of a combined approach by chemotherapy and subsequent resection. 2nd World Cong. Intern. Hepato-Pancreatico-Biliary Ass., Bologna, Italy, 2-6 June 1996, HPB Surgery, 1996, 9 (2) : 1 (abstr. F001).

Lévi F. : La chimiothérapie chronomodulée dans les cancers colorectaux : intérêt en 2ème ligne. Proc. Eurocancer 96, Paris, France, 4-6 Juin 1996.

Mormont C., Lévi F. : Rhythm assessment in cancer patients : rest-activity cycle. Chronobiology and cancer (E.O.R.T.C. Study Group of Chronotherapy). September 8-10 1996, Ottrott (Strasbourg), France.

Lévi F. : Most suitable cytostatics for chronotherapy. Chronobiology and cancer (E.O.R.T.C. Study Group of Chronotherapy). September 8-10 1996, Ottrott (Strasbourg), France.

Giacchetti S., Lévi F. : Strategy for colorectal and pancreatic tumors. Chronobiology and cancer (E.O.R.T.C. Study Group of Chronotherapy). September 8-10 1996, Ottrott (Strasbourg), France.

Lévi F., Gruia G., Giacchetti S., Deprés-Brummer P., Jami A., Zidani R., Bleuzen P., Misset J.L. : Role of time of peak delivery of chronomodulated 5-fluorouracil (5-FU), l-leucovorin (LV) and oxaliplatin (L-OHP) in patients with metastatic colorectal cancer (MCC). Chronobiol. Intern., 1996, 13 (Suppl. 1) : 68, 7th Intern. Conf. Chronopharmacol. Chronother., September 10-14, 1996, Heidelberg, Germany.

Mormont M.C., Comisso M., Langouët A.M., Massari C., Bogdan A., Marion S., Touitou Y., Jasmin C., Lévi F. : Cortisol and hematologic circadian rhythms in patients with metastatic colorectal cancer. Chronobiol. Intern., 1996, 13 (Suppl. 1) : 92, 7th Intern. Conf. Chronopharmacol. Chronother., September 10-14, 1996, Heidelberg, Germany.

Mormont M.C., Langouët A.M., Massari C., Bogdan A., Metzger G., Misset J.L., Touitou Y., Lévi F. : Selection and validation of a simple, non-invasive test of circadian rhythms in patients with colorectal cancer : consequences for chronotherapy. Chronobiol. Intern., 1996, 13 (Suppl. 1) : 93, 7th Intern. Conf. Chronopharmacol. Chronother., September 10-14, 1996, Heidelberg, Germany.

Li X.M., Ezan E., Soulard C., Filipski E., Deschamps de Paillette E., Lévi F. : Circadian-based goralatide-G-CSF combination for protecting bone marrow against aracytine in mice. Chronobiol. Intern., 1996, 13 (Suppl. 1) : 73, 7th Intern. Conf. Chronopharmacol. Chronother., September 10-14, 1996, Heidelberg, Germany.

Lévi F. : Chronotherapy of colon carcinoma. 4th Postgraduate Conference in Clinical Oncology, September 25-29 1996, Heraklion, Crete.

Giacchetti S., Itzhaki M., Adam R., Deprés-Brummer P., Zidani R., Brienza S., Bleuzen P., Cvitkovic F., Gruia G., Jasmin C., Bismuth H., Misset J.L., Lévi F. : Long term survival of patients (pts) with unresectable colorectal liver metastases, following infusional chronotherapy with 5-fluorouracil (5-FU), folinic acid (FA), oxaliplatin (L-OHP) and surgery. Proc. 21st Cong. Eur. Soc. Med. Oncol., Ann. Oncol., 1996, 7 (Suppl. 5) : 34 (abstr. 153 O), présentation orale.

Bozec L., Lévi F., Bierling P., Debat P., Delaloge S., Cvitkovic E. : A case of immune thrombocytopenia indiced by irinotecan (CPT-11, CAMPTOÒ). Proc. 21st Cong. Eur. Soc. Med. Oncol., Ann. Oncol., 1996, 7 (Suppl. 5) : 34 (abstr. 179P).

Wasserman E., Bleuzen P., Giacchetti S., Deprés-Brummer P., Bertheault-Cvitkovic F., Brienza S., Zidani R., Adam R., Jasmin C., Misset J.L., Lévi F. : Infusional chronomodulated (CHRONO) combination of oxaliplatin (L-OHP) and 5-fluorouracil (FU), folinic acid (FA) in patients with FU ± FA refractory metastatic colorectal cancer (MCC). Proc. 21st Cong. Eur. Soc. Med. Oncol., Ann. Oncol., 1996, 7 (Suppl. 5) : 34 (abstr. 164P).

Curé H., Garufi C., Focan C., Bousquet J., Bertheault-Cvitkovic F., Zidani R., Pezet D., Terzoli L., Chollet P., Lévi F. for the International Organisation for Cancer Chronotherapy : A Phase I-II assessment of five-day chronomodulated (CHRONO) 5-fluorouracil (5-FU) - leucovorin (LV) against metastatic colorectal cancer. Proc. 21st Cong. Eur. Soc. Med. Oncol., Ann. Oncol., 1996, 7 (Suppl. 5) : 34 (abstr. 169P).

Lévi F. : Chronomodulation of chemotherapy against metastatic colorectal cancer. 4th International Postgraduate Course in Hepatobiliary, Pancreatic and Gastric Diseases, 1996, December 5-7, Athens, Greece.

Adam R., Bismuth H., Farabos C., Lévi F., Waechter F., Engerran L. : Résection après chimiothérapie des métastases hépatiques initialement non résécables de cancer colorectal. Proc. Journées Francophones de Pathologie Digestive, Lille (France), 23-27 Mars 1996 Gastroenter. Clin. Biol., 1996, 20 (2bis) : A33.

Sebagh, Adam R., Lemoine A., Waechter F., Reynes M., Lévi F., Bismuth H. : Evaluation histologique et biochimique de la toxicité hépatique d’une chimiothérapie systémique. Proc. Journées Francophones de Pathologie Digestive, Lille (France), 23-27 Mars 1996 Gastroenter. Clin. Biol., 1996, 20 (2bis) : A1.

Lévi F. : Chronothérapie des cancers. 2èmes Journées de T.P.H., Paris, 22-23 Mars 1996, Thérapeutique et Pratique Hospitalières, 1996, n° 42, 4, vol. 7 : 7.

Lévi F : Chronothérapie des métastases des cancers colorectaux. Symposium sur les Traitements Médico-chirurgicaux des Métastases des Cancers Colorectaux, Toulouse, 15 Novembre 1996.

1997

Lévi F., Deprés-Brummer P., Bourin P., Metzger G. : Multi-oscillator models for circadian system chronopharmacology. Proc. Biological Rhythms : Physiological and Molecular Mechanisms, NSF-CNRS International Workshop on Chronobiology, March 9-12 1997, Lyon, France, p. 18.

Li X.M., Metzger G., Lévi F. : Pharmacologic modulation of liver reduced glutathione and bone marrow proliferative rhythms in synchronized mice. Proc. Biological Rhythms : Physiological and Molecular Mechanisms, NSF-CNRS International Workshop on Chronobiology, March 9-12 1997, Lyon, France, p. 37.

Liu X.H., Metzger G., Sfaksi N., Misset J.L., Lévi F. : Circadian changes in cell cycle progression and Bcl-2 oncoprotein expression in mouse bone marrow. Proc. Biological Rhythms : Physiological and Molecular Mechanisms, NSF-CNRS International Workshop on Chronobiology, March 9-12 1997, Lyon, France, p. 38.

Lévi F. : Rythmes biologiques, chronothérapie et dérivés nitrés. Symposium Franco-Espagnol : Coeur, endothelium et dérivés nitrés, Barcelone, Espagne, 4-5 Avril 1997, Annales de Cardiologie et d’Angeiologie, 1997, 46 (7) : 426-430.

Filipski E., Breillout F., Lévi F. : Cure rate linked to circadian tolerability rhythm of vinorelbine in P388 leukemic mice. Proc. 88th Annual Meeting Am. Ass. Cancer Res., April 12-16, 1997, San Diego, CA, U.S.A., vol. 38 : abstr. # 1570.

Filipski E., Lévi F.,Vadrot N., Li X.M., Mormont C., Lemaigre G., Mahjoubi M. : Circadian changes in irinotecan toxicity in mice. Proc. 88th Annual Meeting Am. Ass. Cancer Res., April 12-16, 1997, San Diego, CA, U.S.A., vol. 38 : abstr. # 2048.

Mormont M.C., Rozand S., Maoudj E., Reggane M., Metzger G., Tisserand H., Clément G., Corrand J.A., Lévi F. : Mélodie : a precision pump for automatic, time-qualified infusion of complex, multi-agent therapy. Proc. 88th Annual Meeting Am. Ass. Cancer Res., April 12-16, 1997, San Diego, CA, U.S.A., vol. 38 : abstr. # 4074.

Van den Heiligenberg S.M., Deprés P., Barbason H., Claustrat B., Reynes M., Lévi F. : Promoting effect of constant light (LL) on hepatocarcinogenesis in rats. Proc. 88th Annual Meeting Am. Ass. Cancer Res., April 12-16, 1997, San Diego, CA, U.S.A., vol. 38 : abstr. # 3923.

Lévi F., Dogliotti L., Perpoint B., Zidani R., Giacchetti S., Chollet P., Le Rol A., Llory J.F., Focan C., Kunstlinger F., Adam R., Vannetzel J.M., Letourneau Y., Jasmin C., Bismuth H., Misset J.L. : A multicenter Phase II trial of intensified chronotherapy with oxaliplatin (L-OHP), 5-fluorouracil (5-FU) and folinic acid (FA) in patients (pts) with previously untreated metastatic colorectal cancer (MCC). Proc. 33rd Annual Meeting Am. Soc. Clin. Oncol., May 17-20, 1997, Denver, CO, U.S.A., abstr. # 945.

Assier I., Léger-Enreille A., Kwiatowski F., Bargnoux P.J., Curé H., Pezet D., Ouabdesselam R., Chipponi L., Lévi F., Chollet P. : Relationship of dose-limiting toxicity (DLT) with plasma 5-fluorouracil (5-FU) accumulation in high-dose chronomodulated (CM) infusion of 5-FU and L-folinic acid (L-FA). Proc. 33rd Annual Meeting Am. Soc. Clin. Oncol., May 17-20, 1997, Denver, CO, U.S.A., abstr. # 808.

Giacchetti S., Zidani R., Perpoint B., Pinel M.C., Faggiuolo R., Focan C., Letourneau Y., Chollet P., Llory J.F., Coudert B., Bertheault-Cvitkovic F., Adam R., Le Bail N., Misset J.L., Bayssas M., Lévi F. : Phase III trial of 5-fluorouracil (5-FU), folinic acid (FA), with or without oxaliplatin (OXA) in previously untreated patients (pts) with metastatic colorectal cancer (MCC). Proc. 33rd Annual Meeting Am. Soc. Clin. Oncol., May 17-20, 1997, Denver, CO, U.S.A., abstr. # 805. (Présentation orale)

Mormont M.C., Bleuzen P., Lellouch J., Misset J.L., Lévi F. : Prognostic value of circadian rhythm assessment for survival of patients with metastatic colorectal cancer. Proc. 33rd Annual Meeting Am. Soc. Clin. Oncol., May 17-20, 1997, Denver, CO, U.S.A., abstr. # 956.

Lévi F. : Randomized clinical trials with chronotherapy in advanced colorectal cancer. Medical Management of Colorectal Cancer, International Conference Association Européenne de Recherche en Oncologie, Cannes, France, June 21 1997.

Lévi F., Deprés-Brummer P., Bourin P., Claustrat B., Touitou Y., Metzger G. : Multioscillator models for circadian chronopharmacology. Proc. Int. Cong. on Chronobiology, 7-11 Septembre 1997, Paris, France. Chronobiol. Intern., 1997, 14 (suppl. 1) : abstr. 190

Mormont M.C., Claustrat B., Waterhouse J., Touitou Y., Lévi F. : Clinical relevance of circadian rhythm assessment in cancer patients. Proc. Int. Cong. on Chronobiology, 7-11 Septembre 1997, Paris, France. Chronobiol. Intern., 1997, 14 (suppl. 1) : abstr. 238

Sfaksi N., Metzger G., Filipski E., Lévi F. : Circadian system alteration in mice by constant light or darkness exposure. Proc. Int. Cong. on Chronobiology, 7-11 Septembre 1997, Paris, France. Chronobiol. Intern., 1997, 14 (suppl. 1) : abstr. 311

Lévi F. : Chronothérapie dans les cancers colorectaux avancés. Proc. 1er Congrès National sur les Dispositifs Intraveineux de Longue Durée, Paris (France), 17-18 Octobre 1997.

Lévi F. : Chronothérapie - Principes généraux. Journée Régionale de Cancérologie, Lille, France, 13 Décembre 1997.

1998

Lévi F. : Technologies and logistic for ambulatory patient in cancer chronotherapy. European Meeting - Léonardo Da Vinci - Interface collaboration between industrialists and users concerning all new responsabilities regarding new technologies in the health field, Paris, January 9-10 1998.

Lévi F. : Practical issues and present goals of cancer chronotherapy. Nodddeutscher Zytostatika Workshop, January 23-25 1998, Hamburg, Germany.

Lévi F. : Preoperative (chronomodulated) chemotherapy for liver metastasis. European Postgraduate Gastro-Surgical School Meeting : Imaging and treatment of hepatic tumor. February 5-6 1998, Amsterdam, The Netherlands.

Liu X.H., Filipski E., Metzger G., Lévi F. : Vinorelbine-induced G1 phase arrest and p53 overexpression in mouse bone marrow (BM). Relationship with toxicity circadian rhythm. Proc. 89th Annual Meeting Am. Ass. Cancer Res., 1998, 39 : abstr. 1138.

Montembault S., Goldwasser F., Brezault-Bonnet C., Giacchetti S., Tigaud J.M., Metzger G., Jasmin C., Misset J.L., Lévi F. : A pilot study of CPT- 11 chronomodulated delivery in patients (pts) with metastatic colorectal carcinoma (CRC). Proc. 89th Annual Meeting Am. Ass. Cancer Res., 1998, 39 : abstr. 3444.

Goldwasser F., Pourquier P., Gutierrez-Toro Y., Misset J.L., Pommier Y., Lévi F. : Effect of melatonin upon CPT-11-induced DNA damages, cell cycle response and cytotoxicity. Proc. 89th Annual Meeting Am. Ass. Cancer Res., 1998, 39 : abstr. 3579.

Lévi F. : Infusione cronomodulata : razionale e studi preclinici. Workshop Le infusioni in oncologia. 20-21 Avril 1998, Rome. (Invité)

Mormont M.C., Giacchetti S., Waterhouse J., Lellouch J., Misset J.L., Lévi F. : Activity circadian rhythm as an independent prognostic factor of survival in patients (pts) with metastatic colorectal cancer (MCC). . Proc. 34th Ann. Meeting Am. Soc. Clin. Oncol., 1998, 17 : abstr. 1032.

Lévi F., Zidani R., Giacchetti S., Llory J.F., Dogliotti L., Perpoint B., Chollet P., Focan C. for the I.O.C.C. : First line chemotherapy with 5-fluorouracil (5-FU), leucovorin, and oxaliplatin (l-OHP) (FLO) against metastatic colorectal cancer (MCC) : relationship between chronotherapy, dose intensity (DI), response and survival. Proc. 34th Ann. Meeting Am. Soc. Clin. Oncol., 1998, abstr. 1044.

Curé H., Adenis A., Tubiana-Mathieu N., Ouabdesselam R., Kwiatkowski F., Perpoint B., Coudert B., Focan C., Giacchetti S., Lévi F., Chollet P. : Phase II trial of chronomodulated (cm) high dose 5-fluorouracil (5-FU) and l-folinic acid (l-FA) in patients with metastatic colorectal cancer (MCC). Proc. 34th Ann. Meeting Am. Soc. Clin. Oncol., 1998, abstr. 1048.

Giacchetti S., Brienza S., Focan C., Metouri A., Perpoint B., Faggiuolo R., Llory J.F., Le Rol A., Larregain-Fournier D., Tigaud J.M., Debotte G., Itzhaki M., Misset J.L., Lévi F. : Contribution of second line oxaliplatin (oxa)-chronomodulated 5-fluorouracil - folinic acid (CM-5-FU-FA) and surgery to survival in metastatic colorectal cancer patients (MCC pts). Proc. 34th Ann. Meeting Am. Soc. Clin. Oncol., 1998, abstr. 1050.

Lévi F. : Chronopharmacology of growth factors and cytokines. 15th International Conference of the International Academy of Tumor Marker Oncology, Lugano, Switzerland, June 14-17 1998. (Invité)

Lévi F. : Cancer chronotherapeutics. Proc. British Pharmaceutical Conference 1998, 135th meeting, Eastbourne, England, September 8-11 1998, J. Pharmacy Pharmacol., 1998, 50 (suppl.) : 4. (Invité)

Lévi F. : Cancer chronotherapeutics. Proc. 98’ International Conference on Prevention and Treatment of Cancer with the Integrated Traditional Chinese and Western Medicine, GuangZhou, China, November 3-6 1998. (Invité)

X.H. Liu, Metzger G., X.M. Li, Mormont M.C., Filipski E., Amat S., Lévi F. : Circadian-dependent and sex-related norcantharidin toxicity in mice. Proc. 98’ International Conference on Prevention and Treatment of Cancer with the Integrated Traditional Chinese and Western Medicine, GuangZhou, China, November 3-6 1998.

F. Lévi : Chronotherapy of cancer : an update. 6th Convegno Nazionale della Societa Italiana di Cronobiologia, Chianciano Terme, Italia, 27-28 Novembre 1998. (Invité)

Lévi F., Giacchetti S., Zidani R., Brezault-Bonnet C., Tigaud J.M., Goldwasser F., Misset J.L. : Chronotherapy of colorectal cancer metastases. Liver Cancer : Multi treatment Modalities, Imperial College School of Medicine, London, England, November 25th 1998, Hepato-Gastroenterology Journal.

Touitou Y., Bogdan A., Lévi F., Mormont C., Auzéby A. : Circadian rhythm alterations of plasma cortisol in cancer patients. 4th International Symposium on Predictive Oncology & Therapy, Nice (France) 24-27 Octobre 1998

Lévi F. : Chronopharmacologie antitumorale. 30ème Congrès Annuel Société Francophone de Chronobiologie, Groupe d’Etudes des Rythmes Biologiques, Lyon , 25-27 Mai 1998.

Mormont M.C., Waterhouse J., Lévi F. : Evaluation prospective de la pertinence clinique du rythme circadien d’activité par actométrie chez 200 patients atteints de cancer colorectal métastasé. 30ème Congrès Annuel Société Francophone de Chronobiologie, Groupe d’Etudes des Rythmes Biologiques, Lyon , 25-27 Mai 1998.

Marchenay C., Cellarier E., Buchdahl C., Kwiatkowski F., Claustrat B., Brun J., Lévi F., Madelmont J.C., Chollet P. : Rythme circadien de l’activité de l’O6-alkylguanine-ADN alkyltransferase dans les cellules mononucléées circulantes du sujet adulte sain. 30ème Congrès Annuel Société Francophone de Chronobiologie, Groupe d’Etudes des Rythmes Biologiques, Lyon , 25-27 Mai 1998.

Cellarier E., Marchenay C., Rolhion C., Kwiatkowski F., Dubray C., Medelmont J.C., Chollet P., Lévi F. : Etude du rythme circadien de l’expression du gène de l’O6-alkylguanine-ADN alkyltransferase dans les cellules mononucléées circulantes du sujet adulte sain. 29ème Congrès Annuel du Groupe d’Etude des Rythmes Biologiques, Lyon, 25-27 Mai 1998.

Servière J., Liu X.H., Filipski E., Li X.M., Bertel O., Caillol M., Chambille I., Lavialle M., Lévi F. : Rôle des noyaux suprachiasmatiques dans la chronopharmacologie : effets de leur destruction sur les variations circadiennes du cycle cellulaire et du glutathion chez le Rat (étude préliminaire). 30ème Congrès Annuel Société Francophone de Chronobiologie, Groupe d’Etudes des Rythmes Biologiques, Lyon , 25-27 Mai 1998.

Filipski E., Lévi F. : Relations entre rythme circadien, dose, toxicité et efficacité de 2 antimitotiques chez la Souris. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998.

Li X.M., Lévi F. : Perturbations des rythmes thermiques et activité-repos induites par la vinorelbine chez la Souris. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998. 

Metzger G., Lévi F. : Formation d’adduits Pt-ADN, en tant que mécanismes du rythme de toxicité de l’oxaliplatine. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998.

Liu X.H., Lévi F. : Relations entre expression de P53 et rythme circadien de toxicité de la vinorelbine chez la souris. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998.

Zidani R., Lévi F. : Essais cliniques multicentriques de chronothérapie. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998.

Mormont M.C., Lévi F. : Actométrie et test de rythme de cortisol chez 200 patients atteints de métastases de cancer colorectal. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998.

Cellarier E., Lévi F. : Rythmes de l’alkylguanine transferase dans les mononucléaires humains. Relations entre activité et expression mesurées par RT-PCR. Congrès de l’Association de Chronobiologie Médicale, Bordeaux, 23-25 Septembre 1998.

F. Lévi : La chronomodulation en 1998. Journée de Formation et d’Information Sanofi, Bénodet, 27 Juin 1998

Lévi F. : La sortie du patient en suivi à domicile. HAD Réseaux Santé 98, Table Ronde, Paris, 16-18 Décembre 1998.

1999

Lévi F., Zidani R., Giacchetti S., Chollet P., Focan C., Dogliotti L., Perpoint B., Garufi C. for the Chronotherapy Study Group of the European Organisation for Research and Treatment of Cancer : Chronotherapy with 5-fluorouracil, leucovorin and oxaliplatin against metastatic colorectal cancer. International Conference on Chemotherapeutic Strategies for Treatment of Colorectal Cancer. Present and Future Developments, Amsterdam, The Netherlands, February 10-12 1999.

Curé H., Pezet D., Kwiatkowski F., Léger-Enreille A., De Renzis J.P., Chevalier V., Chipponi J., Lévi F., Chollet P. : 5-fluorouracil (5-FU) and l-folinic acid (l-FA) pharmacokinetics during chronomodulated (CM) delivery. International Conference on Chemotherapeutic Strategies for Treatment of Colorectal Cancer. Present and Future Developments, Amsterdam, The Netherlands, February 10-12, 1999.

Adenis A., Curé H., Tubiana-Mathieu N., Coudert B., Perpoint B., Kwiatkowski F., Focan C., Leduc F., Giacchetti S., Chollet P., Lévi F. for the Chronotherapy Study Group of the European Organisation for Research and Treatment of Cancer : Final results of a large phase II study of a high dose 5-fluorouracil (5-FU) and l-folinic acid (FA) chronomodulated (chrono) combination in advanced colorectal cancer (ACC). . International Conference on Chemotherapeutic Strategies for Treatment of Colorectal Cancer. Present and Future Developments, Amsterdam, The Netherlands, February 10-12, 1999.

Lévi F. : Therapeutic implications of circadian rhythms in cancer patients. Novartis Foundation Symposium : Mechanisms and biological significance of pulsatile hormone secretion. London, United Kingdom, March 2-4 1999. (Invité)

Lévi F., Focan C., Chollet P., Dogliotti L., Garufi C., Perpoint B. for the Chronotherapy Study Group :  E.O.R.T.C. Scientific Strategy Meeting, Brussels, Belgium, March 25-26 1999.

Lévi F., Chollet P., Coudert B., Dogliotti L., Focan C., Garufi C., Giacchetti S., Perpoint B., Smaaland R., Tubiana N., Baron B., Di Paola E. : Projects/strategies for the next 5 years. E.O.R.T.C. Scientific Strategy Meeting, Brussels, Belgium, March 25-26 1999.

Li X.M., Filipski E., Vincenti M., Lévi F. : Vinorelbine-induced alteration of circadian clock function : potential implications for drug-scheduling. Proc. Am. Ass. Cancer Res., 1999, 40 : 286 (abstr. 1898).

Metzger G., Maffrand J.P., Misset J.L., Le Fur G., Lévi F. : Kinetics of platinum (Pt) binding to DNA in mouse organs after oxaliplatin (l-OHP) administration. Effect of buthionine sulfoximine (BSO). Proc. Am. Ass. Cancer Res., 1999, 40 : 392 (abstr. 2597).

Marchenay C., Cellarier E., Rolhion E., Kwiatkowski F., Claustrat B., Lévi F., Madelmont J.C., Chollet P. : Circadian variation in O6-alkylguanine-DNA alkyltrnasferase activity in circulating blood mononuclear cells of healthy human subjects. Proc. Am. Ass. Cancer Res., 1999, 40 : 403 (abstr. 2664).

Filipski E., Liu X.H., Vrignaud P., Bissery M.C., Lévi F. : Chronopharmacologic optimization of docetaxel-doxorubicin combination in mice with P388 leukemia. Proc. Am. Ass. Cancer Res., 1999, 40 : 589 (abstr. 3885).

Curé H., Kwiatkowski F., Pezet D., Bay J.O., Chevalier V., Chevrier R., Bargnoux P.J., Léger-Enreille A., Lévi F., Chollet P. : A new prognostic of response and toxicities in metastatic colorectal cancer treated by chronomodulated infusion of high-dose 5-fluorouracil and folinic acid. Proc. Am. Soc. Clin. Oncol., 1999, 18 : 174a (abstr. 667).

Mormont M.C., Claustrat B., Langouët A.M., Giacchetti S., Massari C., Bogdan A., Marion S., Touitou Y., Jasmin C., Waterhouse J., Misset J.L., Lévi F. : Circadian rhythms alterations in patients with metastatic colorectal cancer and good performance status. Proc. Am. Soc. Clin. Oncol., 1999, 18 : 253a (abstr. 972).

Giacchetti S., Zidani R., Goldwasser F., Brezault-Bonnet C., Tigaud J.M., Mormont C., Montembault S., Misset J.L., Lévi F. : Chronomodulated CPT-11. A pilot study. Proc. Am. Soc. Clin. Oncol., 1999, 18 : 259a (abstr. 996).

Filipski E., Tampellini M., Liu X.H., Lemaigre G., Lévi F. : Preclinical chronopharmacology of new anticancer drugs. Proc. Joint meeting 8th International Conference of Chronopharmacology and Chronotherapeutics and The American Association for Medical Chronobiology and Chronotherapeutics, August 24-28 1999, Williamsburg, VA, U.S.A., Chronobiol. Int., 1999, 16 (Suppl. 1) : 34.

Lévi F., Dogliotti L., Perpoint B., Giacchetti S., Focan C., Chollet P., Tubiana N., Zidani R. on behalf of the Chronotherapy Study Group of the European Organisation for Research and Treatment of Cancer (EORTC) : Chronotherapy against metastatic colorectal cancer (MCC). Proc. Joint meeting 8th International Conference of Chronopharmacology and Chronotherapeutics and The American Association for Medical Chronobiology and Chronotherapeutics, August 24-28 1999, Williamsburg, VA, U.S.A., Chronobiol. Int., 1999, 16 (Suppl. 1) : 67.

Mormont M.C., Waterhouse J., Claustrat B., Touitou Y., Lévi F. : Invasive vs non-invasive rhythm assessment in cancer patients. Proc. Joint meeting 8th International Conference of Chronopharmacology and Chronotherapeutics and The American Association for Medical Chronobiology and Chronotherapeutics, August 24-28 1999, Williamsburg, VA, U.S.A., Chronobiol. Int., 1999, 16 (Suppl. 1) : 77.

Lévi F. : Relevance of circadian rhythms for the pharmacology of anticancer drugs. In vitro rhythms in bone marrow proliferation. Workshop on  “Cellular Regulatory Mechanisms of Circadian Clocks”, Fondation des Treilles, Tourtour (France), 4-10 September 1999. (Invité)

Joly A.C., Monnet I., Chouaid C., Metzger G., Mormont M.C., Lévi F., Housset B. : Continuous infusion of 5-fluorouracil and non-small cell lung cancer (NSCLC) : circadian rhythms and influence of a corticotherapy. Proc. 28th Eur. Symp. Clin. Pharm. of the Eur. Soc. Clin. Pharm., Berlin, Germany, October 14-16 1999, abstr. # 195.

Lévi F. : Chronotherapy with 5-fluorouracil, leucovorin and oxaliplatin against metastatic colorectal cancer. The Sixth International Conference on Gastrointestinal Cancer : pancreas, biliary tract and hepatic metastasis, Williamsburg, VA, U.S.A., October 20-22 1999. (Invité)

Li X.M., Liu X.H., Filipski E., Metzger G., Delagrange P., Jeanniot J.P., Lévi F. : Atypical melatonin circadian rhythm in B6D2F1 mice. 29th Annual Meeting Society for Neuroscience, Miami Beach, U.S.A., 1999, Oct. 23-28.

Lévi F. : Relevance of circadian rhythms for the pharmacology of anticancer drugs and cancer treatments. International Symposium on “Time and Timing in Biological Systems”, Kloster Seeon, Allemagne, November 5-8 1999. (Invité)

Lévi F. : Chronotherapy. French-Israeli Conference on Gastro-Intestinal Oncology, Eilat, Israel, November 10-13 1999. (Invité) 

D’Attino R.M., Filipski E., Granda T.G., Garufi C., Terzoli E., Lévi F. : Irinotecan (CPT-11) and oxaliplatin (l-OHP) chronoefficacy in a murine transplantable tumor. XXVII Symposium of the Italian Cancer Society, Milano, November 22-24 1999.

Deprés-Brummer P., Mahjoubi R., Zidani R., Llory J.F., Bertheault-Cvitkovic F., Vannetzel J.M., Lévi F. : Chronomodulated chemotherapy (CMC) with mitoxantrone (MX), 5-fluoruoracil (5-FU) and folinic acid (FA) for metastatic breast cancer (MBC). A phase I-II study. Proc. 22nd Annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment, 1999, 57 (1) : abstr. # 358.

Lévi F.,Giacchetti S., Chollet P., Perpoint B., Coudert B., Bertheault-Cvitkovic F., Curé H., Llory J.F., Le Rol A., Larregain-Fournier D., Adenis A., Brézault-Bonnet C., Walter S., Tigaud J.M., Zidani R., Tubiana-Mathieu N., Adam R., Misset J.L. pour le Chronotherapy Study Group de l’E.O.R.T.C. : Chronothérapie des cancers colorectaux métastatiques par l’association 5-fluorouracile – acide folinique et oxaliplatine. Xème Journée Scientifique de la Fondation Française de Cancérologie Digestive, 22 Janvier 1999, Paris.

Lévi F. : Essai comparatif de plusieurs schémas chronomodulés dans les cancers colorectaux ; chronotolérance vs chronoefficacité ? 10ème Congrès de l’Association de Chronobiologie Médicale, Aussois, 12-15 Septembre 1999.

Lévi F., Giacchetti S., Mormont C., Zidani R., Filipski E., Misset J.L. : Implications des rythmes biologiques pour la thérapeutique anticancéreuse. 8ème Journée de la Recherche : Innovation thérapeutique, Faculté de Médecine Paris Sud, Paris, 8 Décembre 1999.

2000

Granda T.G., Filipski E., D’Attino R.M., Vrignaud P., Bissery M.C., Lévi F. : Chronopharmacology of docetaxel and doxorubicin in mice with MA13/C mammary adenocarcinoma. Proc. 91st Annual Meeting Am. Ass. Cancer Res., April 1-5 2000, San Francisco U.S.A., 2000, 41 : abstr. # 1267.

D’attino R.M., Filipski E., Granda T.G., Vrignaud P., Bissery M.C., Marceau-Suissa J., Garufi C., Terzoli E., Lévi F. : Irinotecan (CPT-11) and oxaliplatin (l-OHP) synergistic activity at specific circadian times in tumor-bearing mice. Proc. 91st Annual Meeting Am. Ass. Cancer Res., April 1-5 2000, San Francisco U.S.A., 2000, 41 : abstr. # 1268.

Chevalier V., Kwiatovsky F., Curé H., Pezel D., Chevrier R., Leger-Enreille A., Barnoux P.J., Lévi F., Chollet P. : A new prognostic indicator in metastatic colo-rectal cancer treated by chronomodulated infusion of high-dose 5-fluorouracil and l-folinic acid. Proc. 91st Annual Meeting Am. Ass. Cancer Res., April 1-5 2000, San Francisco U.S.A., 2000, 41 : abstr. # 1792.

Etienne M.C., Porsin B., Filipski E., Formento J.L., Francoual M., Rennée N., Lévi F., Milano G. : Dihydropyrimidine dehydrogenase (DPD) circadian rhythm for both enzyme activity and gene expression from mouse liver. Proc. 91st Annual Meeting Am. Ass. Cancer Res., April 1-5 2000, San Francisco U.S.A., 2000, 41 : abstr. # 3127.

Lévi F. : Biliary tract cancer and chronotherapy. G.C.C.D. – E.O.R.T.C. Symposium, Porto, Portugal, April 28-29 2000. (Invité)

Filipski E., King V.M., Li X.M., Hastings M.H., Lévi F. : Rest-activity and body temperature rhythms after suprachiasmatic nucleus destruction in B6D2F1 mice. Proc. 7th Meeting Soc. Res. Biol. Rhythms, Amelia Island Plantation, Florida, U.S.A., May 10-13 2000, 121 (abstr. # 197).

Li X.M., Delagrange P., Lévi F. : Melatonin administration entrains circadian rhythms of temperature and activity in B6D2F1 mice exposed to constant light. Proc. 7th Meeting Soc. Res. Biol. Rhythms, Amelia Island Plantation, Jacksonville, Florida, U.S.A., May 10-13 2000, 107 (abstr. # 169). 

Filipski E., King V.M., Li X.M., Hastings M.H., Lévi F. : Cycle d’activité-repos et rythme thermique après la destruction des noyaux suprachiasmatiques chez la souris B6D2F1. 32ème Cong. Soc. Francophone Chronobiol., Marseille, 15-17 Mai 2000.

Li X.M., Delagrange P., Lévi F. : La mélatonine entraîne les rythmes circadiens de la température et de l’activité chez la souris B6D2F1 exposée en lumière continue. 32ème Cong. Soc. Francophone Chronobiol., Marseille, 15-17 Mai 2000.

Lévi F., Zidani R., Llory J.F. Dogliotti L., Perpoint B., Iacobelli S., Chollet P., Focan C., Garufi C., Le Rol A., Giacchetti S., Misset J.L. for the International Organization for Cancer Chronotherapy : Final efficacy update at 7 years of flat vs chronomodulated infusion (chrono) of oxaliplatin, 5-fluorouracil and leucovorin as first line treatment of metastatic colorectal cancer. Proc. 36th Ann. Meeting Am. Soc. Clin. Oncol., May 20-23 2000, New-Orleans, U.S.A., 2000, 19 : 242a (abstr. # 936) (Présentation orale, sélectionnée pour diffusion sur internet).

Giacchetti S., Zidani R., Chollet P., Dogliotti L., Kunstlinger F., Le Rol A., Garufi C., Brienza S., Focan C., Bertheault-Cvitkovic F., Misset J.L., Lévi F. : Chronotherapy of metastatic colorectal cancer (MCC) with 5-fluorouracil (5-FU)-leucovorin (LV)-oxaliplatin (l-OHP) as second to seventh line treatment. Proc. 36th Ann. Meeting Am. Soc. Clin. Oncol., May 20-23 2000, New-Orleans, U.S.A., 2000, 19 : 318a (abstr. # 1255).

Lévi F. : Chronotherapy of metastatic colorectal cancer. Metastases hepaticas avanços no tratamento multidisciplinar, July 7-8 2000, Instituto Portuges de Oncologia, Lisboa, Portugal. (Invité)

Lévi F. : Chronotherapy in the management of patients with GI cancer. Satellite Symposium : Chronomodulierte chemotherapie, Gemeinsame Jahrestagung der Deutschen und Österreichischen gesellschaften für Hämatologie und Onkologie, Graz, Austria, October 21-25 2000. (Invité)

Claude D., Clairambault J., Lévi F. : Rythmes biologiques et chronothérapeutique : comparaison entre des schémas d'administrations théoriques et des thérapeutiques appliquées en cancérologie. In : Programme de Recherche Automatique Biologie et Santé : modélisation et commande de régulations biologiques, Proc. ESAIM, D. Claude ed., EP Sciences, Les Ulis France, Cambridge USA, 2000, 9 : 119-137.

2001

Filipski E., King V.M., Mormont M.C., Li X.M., Granda T.G., Hastings M.H., Lévi F.A. : Relevance of circadian coordination for tumor growth and survival in experimental model. Proc. Am. Ass. Cancer Res., March 24-28 2001, New Orleans, U.S.A., 2001, 42 : abstr. # 88.

Liu X.H., Metzger G., Lévi F. : Circadian rhythms in Bcl-2 and Bax protein expressions in mouse bone marrow. Proc. Am. Ass. Cancer Res., March 24-28 2001, New Orleans, U.S.A., 2001, 42 : abstr. # 1646.

Granda T.G., Liu X.H., Filipski E., Vrignaud P., Bissery M.C., Lévi F. : Different rhythms in cell cycle distribution in bone marow and in MA13/C mammary tumor of C3H/HeN mice. Proc. Am. Ass. Cancer Res., March 24-28 2001, New Orleans, U.S.A., 2001, 42 : abstr. # 4897.

Lévi F. : Chronomodulation and L-OHP neurotoxicity. Risposta, qualita di vita e sopravvivenza nel cancro del colon-retto metastatico, March 29-30 2001, Roma, Italia. (Invité)

Lévi F. : From circadian rhythms to cancer chronotherapy. National Academic Seminar on Cancer Chronotherapy and Chronomedicine, April 17-20 2001, Guangzhou, China. (Invité)

Guo L., Lin H., Xian L.J., Jiang W., Giacchetti S., Lévi F. : Chronotherapy with 5-FU – LV and L-OHP in the treatment of advanced colorectal cancer patients failed by the same regimen in conventional injection – 5 cases report. National Academic Seminar on Cancer Chronotherapy and Chronomedicine, April 17-20 2001, Guangzhou, China.

Lévi F., Zidani R., Coudert B., Giacchetti S., Brézault-Bonnet C., Manoux D., Dessard-Diana B., Maoudj E., Franco D., Adam R. : Chronomodulated irinotecan (I) – fluorouracil (F) – leucovorin (L) – oxaliplatin (O) (chrono IFLO) as salvage therapy in patients with heavily pretreated metastatic colorectal cancer (MCC). Proc. Am. Soc. Clin. Oncol., May 12-15 2001, San Francisco, U.S.A., 2001, 20 : 139a (abstr. 552).

Giacchetti S., Cure H., Adenis A., N.Tubiana, L.Vernillet,L. Messali, D.Mille, C.Germa,C. Gayet, P.Chollet, F.Lévi : Randomized multicenter trial of irinotecan chronomodulated versus standard infusion in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Oncol., May 12-15 2001, San Francisco, U.S.A., 2001, 20 : abstr. 2218.

Mormont C., Chedouba-Messali L., Chevalier V., Adenis A., Giacchetti S., Curé H., Germa-Dabancourt C., Waterhouse J., Chollet P., Lévi F. : Chronomodulated vs standard infusion of irinotecan maintains or alters circadian rest/activity rhythm in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Oncol., May 12-15 2001, San Francisco, U.S.A., 2001, 20 : abstr. 2200.

Baron B., Legrand C., Lévi F., Hoctin-Boes G. : Chronomodulation : optimal time finding design. Proc. Society of Clinical Trials Meeting, May 20-23 2001, Denver, U.S.A.

Lévi F., Giacchetti S., Zidani R. : Role of chronotherapy in the medicosurgical management of colorectal cancer metastases. II Jornadas Malaguenas Médico-Quirurgicas - Actualizacion en el Tratamiento del Cancer de Colon, June 22-23 2001, Miras Costa (Malagua), Spain. (Invité)

Filipski E., King V.M., Mormont M.C., Li X.M., Granda T., Hastings M.H., Lévi F. : Circadian dysfunction increases tumor growth rates and decreases survival in mice. Gordon Research Conference on Chronobiology, Rhode Island, USA, August 5-10th 2001.

Kwiatkowski F., Chevalier V., Lévi F., Curé H., Pezet D., Chevrier R., Leger-Enreille A., Chollet P. : New dose optimisation method in chronotherapy and in conventional chemotherapy. Méthodes Statistiques en Biopharmacie, 4ème Cong. Intern., "Integrating Issues of Efficacy, Safety and Cost-Effectiveness", Paris, France, 24-25 Sept. 2001.

Giacchetti S., Curé H., Adenis A., Tubiana N., Vernillet L., Chedouba-Messali L., Chevalier V., Germa C., Chollet P., Lévi F. : Chronomodulated irinotecan (CPT) versus standard infusion in patients with metastatic colorectal cancer, a randomized multicenter trial. Proc. ECCO 11, 21-25 October 2001, Lisbon (Portugal), Eur. J. Cancer, 2001, 37 (Suppl. 6) : S309 (abstr. # 1144).

Li X.M., Beau J., Lévi F. : Altération du système circadien et resynchronisation chez la souris. Proc. 2ème colloque annuel Groupe Francophone de Réflexion sur la Télémétrie, Paris, 6-7 Nov. 2001.

Filipski E., King V.M., Mormont M.C., Li X.M., Granda T., Hastings M.H., Lévi F. : Relevance of circadian coordination for tumor growth and survival in experimental model. 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Granda T.G., Liu X.H., Filipski E., Vrignaud P., Bissery M.C., Lévi F. : Different rhythms in cell cycle distribution in bone marrow and in MA13/C mammary tumor of C3H/HeN mice. 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Joly A.C., Monnet I., Chouaid C., Metzger G., Mormont M.C., Lévi F., Housset B. : Influence d'une corticothérapie sur les concentrations plasmatiques de 5-FU et sur les rythmes circadiens de patients atteints de Cancer Bronchique Non Petite Cellule (CBNPC). 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Lévi F., Zidani R., Coudert B., Giacchetti S., Brézault-Bonnet C., Manoux D., Dessard-Diana B., Maoudj E., Franco D., Adam R. : Chronomodulated irinotecan (I) - fluorouracil (F) - leucovorin (L) - oxaliplatin (O) (chrono IFLO) as salvage therapy in patients with heavily pretreated metastatic colorectal cancer (MCC). 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Li X.M., Vincenti M., Lévi F. : Pharmacological effects of vinorelbine on body temperature and locomotor activity circadian rhythms in mice. 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Liu X.H., Cermakian N., Sassone-Corsi P., Lévi F. : Rhythmic circadian expression of BCL-2 and BAX proteins in relation with clock genes transcription in mouse bone marrow. 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Mormont M.C., Chedouba-Messali L., Chevalier V., Adenis A., Lavau-Denes S., Germa C., Waterhouse J., Lévi F. : Chronomodulated versus standard infusion of irinotecan maintains or alters circadian rest/activity rhythm in patients with metastatic colorectal cancer. 11ème colloque de l’Association de Chronobiologie Médicale, Aussois, 15-18 Mars 2001.

Lévi F.,Giacchetti S., Zidani R., Adam R., Llory J.F., Chollet P., Garufi C., Mille D., Dogliotti L., Iacobelli S., Le Rol A., Bertheault-Cvitkovic F., Brézault-Bonnet C., Tigaud J.M., Jasmin C., Bismuth H., Misset J.L. : Optimisation d'une stratégie multicentrique combinant chimiothérapie et chirurgie des métastases chez des patients atteints de cancer colorectal métastatique. XXVèmes Journées Francophones de Pathologie Digestive, Paris, 24-28 Mars 2001.

Li X.M., Beau J., Lévi F. : Altération du système circadien et re-synchronisation chez la souris. 2ème Colloque Annuel Groupe Francophone de Réflexion sur la Télémétrie, Paris, 6-7 Novembre 2001.

2002

Lévi F. : Treatment of colorectal cancer, with emphasis on metastatic disease. 10as Jornadas Nacionais de Oncologia Medica, Espinho, Porto, Portugal, 30 Janv. - 1 Février 2002. (Invité).

Li X.M. : Daily melatonin treatment sets the period of body temperature and locomotor rhythms at 24 h in mice exposed to constant light. Gordon Research Conference : Pineal Cell Biology, Ventura CA, USA, February 10-15 2002. (Invité)

Lévi F. : Chronotherapy. Controversies in the treatment of liver tumors, Pordenone, Italy, March 1st 2002. (Invité).

Lévi F. : Implication of the recent advances in molecular clock for cancer therapy. Symposium of the Chronotherapy group of the E.O.R.T.C. : From circadian rhythms to cancer chronotherapeutics, 25th German Cancer Congress, Berlin, March 10th 2002. (Invité)

Filipski E. : Relevance of circadian function for cancer processes and therapeutics recent experimental evidence. Symposium of the Chronotherapy group of the E.O.R.T.C. : From circadian rhythms to cancer chronotherapeutics, 25th German Cancer Congress, Berlin, March 10th 2002. (Invité)

Lévi F. : Aktuelle Ergebnisse aus EORTC-studien. 25th German Cancer Congress, Berlin, March 10-14 2002. (Invité)

Filipski E., King V.M., Sun J., Hastings M.H., Lévi F. : Experimental jet lag accelerates malignant growth and shortens survival in tumor-bearing mice. Proc. Am. Ass. Cancer Res., April 6-10 2002, San Francisco, U.S.A., 2002, 43 : abstr. # 4270.

Chevalier V., Papon J., Pezet D., Lévi F., Curé H., Madelmont J.C., Chollet P. : Blood concentrations of interleukin-15 (IL-15) and interleukin-2 (IL-2) in colorectal cancer patients : preliminary results. Proc. Am. Ass. Cancer Res., April 6-10 2002, San Francisco, U.S.A., 2002, 43 : abstr. # 2226.

Lévi F. : Circadian clock-based cancer management. Proc. 1st Guangzhou International Symposium on Oncology, Guangzhou, China, April 28-30 2002 (Invité)

Lévi F., Zidani R., Focan C., Garufi C., Chollet P., Iacobelli S., Dogliotti L., Le Rol A., Giacchetti S., Jasmin C. : Age-independent benefit of chronotherapy with 5-fluorouracil, leucovorin and oxaliplatin in patients with metastatic colorectal cancer within multicenter randomized Phase III trials. Am. Soc. Clin. Oncol, 2002, 21 : 358a (abstr. # 1431).

Giacchetti S., Bjarnason G.A, Garufi C., Tubiana-Mathieu N., Dogliotti L., Iacobelli S., Focan C., Coudert B., Smaaland R., Canon J.L., Humblet Y., Tumolo S., Carvalho C., Adenis A., Schüller J., Topham C., Fillet G., Mille D., Van der Auwera J., Donato di Paola E., Lentz M.A., Baron B., Lévi F. : First line infusion of 5-fluorouracil, Leucovorin, Oxaliplatin for metastatic colorectal cancer chronomodulated versus conventional delivery. A multicenter randomized trial of the EORTC Chronotherapy group. Am. Soc. Clin. Oncol, 2002, 21 : 104b (abstr. # 2231).

Mormont M.C., Ouabdesselam R., Zidani R., Giacchetti S., Waterhouse J., Touitou Y., Jasmin C., Lévi F. : Aging does not alter cortisol and rest activity circadian rhythms in patients with metastatic colorectal cancer. Am. Soc. Clin. Oncol, 2002, 21 : 258b (abstr. # 2850).

Barrat M.A., Mormont M.C., Renée N., Giacchetti S., Goldwasser F., Claustrat B., Milano G., Jasmin C., Lévi F. : .Circadian changes in dehydropyrimidine dehydrogenase activity, cortisol and melatonin in previously-treated patients with very advanced metastatic colorectal cancer. Am. Soc. Clin. Oncol, 2002, 21 : 88b (abstr. # 2163).

Tanaka K., Adam R., Giacchetti S., Castaing D., Kunstlinger F., Zidani R., Bismuth H., Jasmin C., Lévi F. : Intra-arterial hepatic infusion of circadian chronotherapy with irinotecan, 5-fluorouracil and oxaliplatin against liver metastases from colorectal cancer. Am. Soc. Clin. Oncol, 2002, 21 : 122b (abstr. # 2303).

Clairambault J., Claude D., Filipski E., Granda T., Lévi F. : Toxicité et efficacité antitumorale de l'oxaliplatine sur l'ostéosarcome de Glasgow chez la souris : un modèle mathématique. 34ème Congrès de la Société Francophone de Chronobiologie, 14-16 Mai 2002, Paris, France.

R. Zidani, F.Lévi, C. Focan, C. Garufi, P. Chollet, S. Iacobelli, L. Dogliotti, A. LeRol, S. Giacchetti, C. Jasmin : Effet de l’âge sur la tolérance et l’activité de la chronothérapie par 5-FU-AF-l-OHP chez les patients, atteint de cancer colorectal métastatique (CCM) dans une étude randomisée multicentrique. 34ème Congrès de la Société Francophone de Chronobiologie, 14-16 Mai 2002, Paris, France.

T. G. Granda , E. Filipski, F. Lévi : Profil d’expression des proteines BCL-2 et p53 dans l’adénocarcinome mammaire ma13/c. 34ème Congrès de la Société Francophone de Chronobiologie, 14-16 Mai 2002, Paris, France.

XM. Li, E. Mocaër, F. Lévi : Synchronisation pharmacologique des rythmes thermique et d’activité-repos chez la souris exposée en lumière constante. Effet de la mélatonine, de s22153 et de leur association. 34ème Congrès de la Société Francophone de Chronobiologie, 14-16 Mai 2002, Paris, France.

Lévi F. : Circadian interactions with cancer. Proc. 8th Meeting Soc. Res. Biol. Rhythms, Amelia Island Plantation, Jacksonville, Florida, U.S.A., May 22-25 2002. (Invité)

Filipski E., King V., Li X.M., Mormont M.C., Granda T., Claustrat B., Hastings M.H., Lévi F. : Relevance of circadian coordination for tumor growth. Proc. 8th Meeting Soc. Res. Biol. Rhythms, Amelia Island Plantation, Jacksonville, Florida, U.S.A., May 22-25 2002.

Lévi F. : Chronotherapeutics of gastrointestinal malignancies. 6th Yokohama Surgical Forum, August 24th 2002, Yokohama, Japan (Invité)

Lévi F. : Treatment of colorectal cancer with emphasis on metastatic diseases. Numazu Cancer Center, August 29th 2003, Numazu, Japan. (Invité)

J. Clairambault, D. Claude, E. Filipski, T. Granda, F. Lévi : Toxicity and anti-tumour efficacy of oxaliplatin on glasgow osteosarcoama in mice: a mathematical model. Proc. E.S.M.T.B. 5th Conference : Mathematical modelling and computing in biology and medicine, 2-6 July 2002, Milano, Italy, p. 138.

Lévi F. : Relevance of circadian coordination for malignant processes. Therapeutic implications. E.O.R.T.C. Chronotherapy Group Meeting, Nice, France, 17-18 October 2002 (Invité).

Granda T. G., Bjarnason G., Cermakian N., Filipski E., Li X.M., Liu X., Sassone-Corsi P., Jordan R., Lévi F. : Rhythms in BCL-2, cell cycle distribution and circadian clock gene expression in normal tissues and in tumor for improving novel targeted cancer therapy. 14th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, 19-22 November 2002, Frankfurt, Germany, Eur. J. Cancer, 2002, 38 Suppl. 7 : S169 (abstr. # 566).

de Lavalette V., Zidani R., Baron B., Gruia G., Giacchetti S., Lévi F. : Chronomodulation de l’association 5-fluorouracile (5-FU), acide folinique (AF) et oxaliplatine (LOHP) dans le traitement des cancers colorectaux métastatiques . Essai de phase I de recherche du schéma optimal. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Zidani R., Lévi F., Focan C., Garufi C., Chollet P., Iacobelli S., Dogliotti L., Le Rol A., Giacchetti S., Jasmin C. : Effet de l’âge sur la tolérance et l’activité de la chronothérapie 5-fluorouracile, acide folinique et oxaliplatine chez les patients, atteint de cancer colorectal métastatique dans une étude de phase III randomisée multicentrique. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Barrat M.A., Mormont M.C., Renée N., Giacchetti S., Goldwasseur F., Claustrat B., Milano G., Jasmin C., Lévi F. : Variations circadiennes de l'activité de la dihydropyrimidine désydrogénase (DPD), de la cortisolémie et de la mélatonine plasmatique chez des patients atteints de cancers colorectaux métastatiques (MCC). 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Clairambault J., Claude D., Filipski E., Granda T., Lévi F. : Toxicité et efficacité de l'oxaliplatine sur l'ostéosarcome de Glasgow induit chez la souris : un modèle mathématique. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Filipski E., King V.M., Sun J., Hastings M.H., Lévi . : Experimental jet lag accelerates malignant growth and shortens survival in tumor-bearing mice. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Granda T., Filipski E., Lévi F. : Expression des protéines BCL-2 et P53 dans l'adénocarcinome mammaire MA13/C. Effet du docetaxel. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Lévi F. : Implications potentielles de la chronobiologie moléculaire pour la chronothérapeutique. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Li X.M., Mocaër E., Lévi F. : Effet de la S22153, antagoniste de la mélatonine sur le cycle activité-repos et le rythme thermique de la souris B6D2F1. Implications pour la synchronisation circadienne en cas de désynchronisation. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Mormont M.C., Ouabdesselam R., Zidani R., Giacchetti S., Waterhouse J., Touitou Y., Jasmin C., Lévi F. : L'âge n'altère pas le rythme circadien du cortisol et le cycle activité/repos chez les patients porteurs de cancer colorectal métastatique. 12ème colloque de l’Association de Chronobiologie Médicale, Aussois, 17-20 Janvier 2002.

Lévi F. : Les rythmes biologiques, processus universels du monde vivant : définition, caractéristiques, coordination. Colloque "Rythmes de l'enfant : de l'horloge biologique aux rythmes scolaires", Medec 2002, Paris 12-15 Mars 2002. (Invité)

De Lavalette V., Baron B., Zidani R., Giacchetti S., Lévi F. : Chronomodulation de l’association 5-fluoro-uracile, acide folinique et oxaliplatine chez des patients atteints de cancer colorectal métastatique, antérieurement traités : essai de phase I de recherche du schéma optimal. XXIIème Forum de Cancérologie, 4-6 Juin 2002, Paris, France , Bulletin du Cancer, 2002, 89 (5) : abstr. # 120.

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