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Francis Lévi, Warwick Medical School, University of Warwick, July 21, 2014:

- Circadian control of xenobiotic carcinogenesis and cancer pharmacology

- Toward Systems Cancer Chronotherapeutics and its integration into home care 

La Société Francophone de Chronobiologie (SFC) organise son 44ème congrès qui se déroulera du 29-31 octobre 2014

Séance de la Société de Biologie " La chronobiologie " aura lieu le 15 octobre 2014 de 15h00 à 18h00 Institut Curie-Pavillon Curie Amphithéâtre Marie Curie 11, rue Pierre et Marie Curie – Paris 5ème

La soutenance de thèse de Melle Véronique ROCHE sera présentée le 21 mai 2014

Reportage BBC, 13 mai 2014  Chronotherapy: The science of timing drugs to our Body

Journal "Le monde" le 30 avril 2014, "Quand l'horloge biologique se détraque"

 

Voir la suite

Contact

UMRS 935

Equipe3 : Chronothérapie des cancers

et optimisation de la fonction hépatique

INSERM et Université Paris Sud

Bât A 3ème étage Campus CNRS
7 rue Guy Môquet
94801 Villejuif Cedex (France)
Tel :  +33 (0) 1 49 58 34 83
Fax : +33 (0) 1 49 58 34 59
Email:gladys.germe@inserm.fr

Home Production scientifique Publication

2007

Lévi F., Bouchahda M., Innominato P., Giacchetti S., Adam R. : Implications of circadian clocks in liver vs tumor for the rhythmic delivery of anticancer drugs. The Second International Congress of Applied Chronobiology and Chronomedicine, March 23—28th 2007, Tunis-Gammarth, Tunisia. (Invité)

Innominato P., Moreau T., Waterhouse J., Mormont M.C., Giacchetti S., Focan C., Gorlia T., Garudi C., Bjarnason G.A., Lévi F. : Altered circadian rhythm in rest and activity (CIRCACT) : independent prognostic valie for survival in patients (pts) with metastatic colorectal cancer (MCC). The Second International Congress of Applied Chronobiology and Chronomedicine, March 23—28th 2007, Tunis-Gammarth, Tunisia. (Présentation orale)

Iurisci I., Rich T., Lévi F., Innominato P., Tinari N., Irtelli L., De Tursi M., Iacobelli S. : Relief of symptoms following gefitinib is associated with improvement of rest/activity rhythm in patients with advanced non-small-cell lung cancer. The Second International Congress of Applied Chronobiology and Chronomedicine, March 23—28th 2007, Tunis-Gammarth, Tunisia. (Présentation orale)

Lévi F. : Circadian chronotherapeutics in cancer patients. BIOSIM Meeting “Modelling and Biosimulation in the Authorisation Process of Medicinal Products”. The Hague, The Netherlands, May 18th 2007. (Présentation orale)

Lévi F. : Implications of circadian timing system and cell cycle interactions for cell proliferation and cancer therapeutics. 72nd Cold Spring Harbor Symposium on Quantitative Biology, May 30th – June 4th 2007, Cold Spring Harbor, U.S.A. (Invité)

M. Bouchahda, T. Macarulla, J. P. Spano, J. B. Bachet, G. Liedo, T. Andre, B. Landi, J. Tabernero, F. Levi, P. Rougier : Cetuximab and irinotecan-based chemotherapy as an active and safe treatment option for elderly patients with extensively pre-treated metastatic colorectal cancer. Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 14528.

F. Levi, R. Adam, P. Innominato, S. Giacchetti, D. Castaing, D. Hauteville, F. Kunstlinger, X. M. Li, D. Machover, M. Bouchahda : Hepatic artery triplet chemotherapy for liver metastases from colorectal cancer. Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 14554.

T. Aloia, F. Levi, D. A. Wicherts, R. J. Haas, B. Paule, M. Bralet, M. Bouchahda, D. Azoulay, D. Castaing, R. Adam : Hepatic resection following rescue cetuximab treatment for colorectal liver metastases previously refractory to conventional systemic therapy. Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 4061. (Poster)

Karaboue, M. Bouchahda, R. Adam, P. Innominato, M. P. Bralet, T. Moreau, D. Hauteville, C. Guettier, F. Levi : Relevance of a medicosurgical strategy combining cetuximab and chronomodulated (Chrono) chemotherapy (chemo) with metastases resection as 3rd line treatment for patients (pts) with metastatic colorectal cancer (MCRC). Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 14505.

D. A. Wicherts, R. J. Haas, F. Levi, T. Aloia, B. Paule, M. Bralet, F. Kunstlinger, D. Azoulay, D. Castaing, R. Adam : Complete pathological response of colorectal liver metastases after neoadjuvant chemotherapy: myth or reality? Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 4063.

P. F. Innominato, G. A. Bjarnason, C. Garufi, C. Focan, T. Moreau, T. Gorlia, J. Waterhouse, S. Giacchetti, F. A. Lévi : Altered circadian rhythm in rest and activity (CircAct): Independent prognostic value for survival in patients (pts) with metastatic colorectal cancer (MCC). Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 14573.

C. Garufi, C. Focan, S. Tumolo, B. Coudert, S. Iacobelli, N. Tubiana, S. Marreaud, M. Lentz, T. Gorlia, F. Lévi, EORTC Chronotherapy Group : Time finding study of chronomodulated irinotecan (I), fluorouracil (F), leucovorin (L) and oxaliplatin (O) (chronoIFLO) against metastatic colorectal cancer: Results from randomized EORTC 05011 trial. Proc. American Society of Clinical Oncology, 43rd Annual Meeting, June 1-5 2007, Chicago, USA, J. Clin. Oncol., 2007, 25 (No. 18S) : abst. # 2566. (Poster)

Filipski E. : Effect of frequent phase shifts on cancer growth. Society for Light Treatment and Biological Rhythms (SLTBR) 19th Annual Meeting, June 28–30, 2007, Copenhagen, Denmark. (Invitée)

M. Bouchahda, T. Macarulla, J.P. Spano, J.B. Bachet, G. LIedo, T. Andre, B. Landi, J. Tabernero, F. Levi, P. Rougier : Cetuximab and irinotecan-based chemotherapy as an active and safe treatment option for elderly patients with extensively pre-treated  metastatic colorectal cancer. 9th World Congress on Gastro-Intestinal Cancer, June 27-30th 2007, Barcelona, Spain

Lévi F. : Circadian disruption and cancer. From Molecular Clocks To Human Health, 7th – 10th July 2007 Adelaide, Australia. (Invité)

Lévi F. : Circadian and circannual rhythms in human diseases. Interactions between endogenous clocks and environment, and therapeutic implications. Chinese-French and Chinese-European International Congress of Chronomedicine , September 6-8, 2007, ZhuHai, Guangdong, China. (Invité)

Innominato P., Lévi F. : Relations between health-related quality of life, survival and the circadian timing system in cancer patients. Chinese-French and Chinese-European International Congress of Chronomedicine , September 6-8, 2007, ZhuHai, Guangdong, China. (Invité)

Li X.M., F. Lévi : Recent developments in the experimental chronopharmacology of anticancer drugs. Chinese-French and Chinese-European International Congress of Chronomedicine , September 6-8, 2007, ZhuHai, Guangdong, China. (Invitée)

F Lévi, I Iurisci, XM Li, E Filipski, P Innominato, J Beau : Le système circadien, cible thérapeutique. 39ème Congrès de la Société Francophone de Chronobiologie, 19-21 Septembre 2007, Paris. (Présentation orale)

P. F. Innominato, T. Moreau, M. C. Mormont , S. Giacchetti, J. Waterhouse, C. Focan, T. Gorlia, C. Garufi, G. A. Bjarnason, F. A. Lévi : Rythme circadien d’activité et repos (circact) alteré : valeur pronostique pour la survie chez les patients (pats) atteints de cancer colorectal métastatique (ccm). 39ème Congrès de la Société Francophone de Chronobiologie, 19-21 Septembre 2007, Paris. (Présentation orale)

XM Li, E Filipski, P Innominato, R Smaaland, B Claustrat, F Lévi : Altérations du système circadien de l’hôte et de la tumeur au cours de la progression tumorale chez la souris. 39ème Congrès de la Société Francophone de Chronobiologie, 19-21 Septembre 2007, Paris. (Poster)

Arti Parganiha, J. Waterhouse, A. Karaboue, P. Innominato, I. Iurisci, S. Giacchetti, T. Moreau, F. Lévi : Relation between circadian rest-activity rhythm, quality of life and survival in cancer patients. 39ème Congrès de la Société Francophone de Chronobiologie, 19-21 Septembre 2007, Paris. (Présentation orale)

Filipski E., Carrière J. et Lévi  F. : Effets du décalage horaire chronique sur la chronotoxicité de l’oxaliplatine et ses mécanismes chez la souris. 39ème Congrès de la Société Francophone de Chronobiologie, 19-21 Septembre 2007, Paris. (Présentation orale)

Ahowesso C., Li X-M., Lévi F. : Détermination de classes de chronotoxicité de l’irinotécan chez la Souris. 39ème Congrès de la Société Francophone de Chronobiologie, 19-21 Septembre 2007, Paris. (Poster)

Membre du Panel d’Experts de WHO International Agency for Research on Cancer Meeting (IARC)WHO International Agency for Research on Cancer Meeting, Lyon, 1-9 oct 2007, Monograph Working Group : Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol. 2007 Aug;8(8):1065-1066. (Monograph Working Group Members : A Blair—Chair (USA); P Demers (Canada); J Hansen (Denmark); E Pukkala (Finland); F Lévi (France) et al.)

Levi F. : Gender differences in the adjuvant treatment of colorectal cancer metastasis. 14th International GI Oncology Conference, October 25-27, 2007, Charlottesville, U.S.A. (Invité)

Iurisci I., Filipski E., Hassan M., Sallam H., Pham P., Hossard V., Iacobelli S., Lévi F. : Liver effects of  cyclin-dependent kinase inhibitor Seliciclib: relations with circadian pharmacokinetics and liver clock disruption. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, October 22nd - October 26th 2007, San Francisco, USA.

Lévi F. : Essai OPTILIV : Chimiothérapie intra-artérielle + cetuximab pour optimiser le contrôle des métastases hépatiques d’un CCRm. Séminaires sur les Traitements Biologiques des Cancers. Lyon, 18 Avril 2007. (Invité) 

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